<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Diagnosis of pulmonary thromboembolism (PTE) usually includes clinical pretest probability assessment, testing for specific degradation products of cross-linked fibrin (D-dimer) and imaging studies. Patients with radiological findings attributable to pulmonary infarction and normal D-dimer level, may present a diagnostic and therapeutic challenge. A 37-year-old Caucasian female had episodes of hemoptysis, and bilateral pulmonary nodular infiltrates on chest radiograph and computerized tomography. The plasma D-dimer level was normal, perfusion lung scan was not conclusive and histological examination of an open lung biopsy revealed recent thrombotic pulmonary infarction. She deteriorated and more perfusion defects were detected on perfusion lung scan. Genetic analysis revealed her to be a carrier of the prothrombin factor II (FII) G20210A mutation.</p></abstract>

Diagnosis of pulmonary thromboembolism (PTE) usually includes clinical pretest probability assessment, testing for specific degradation products of cross-linked fibrin (D-dimer) and imaging studies. Patients with radiological findings attributable to pulmonary infarction and normal D-dimer level, may present a diagnostic and therapeutic challenge. A 37-year-old Caucasian female had episodes of hemoptysis, and bilateral pulmonary nodular infiltrates on chest radiograph and computerized tomography. The plasma D-dimer level was normal, perfusion lung scan was not conclusive and histological examination of an open lung biopsy revealed recent thrombotic pulmonary infarction. She deteriorated and more perfusion defects were detected on perfusion lung scan. Genetic analysis revealed her to be a carrier of the prothrombin factor II (FII) G20210A mutation.

The Prothrombin Factor II G20210A Mutation with Pulmonary Thromboembolism and a Normal Level of Fibrin Degradation Products

Department of Internal Medicine, School of Medicine, University of Belgrade, Belgrade, Serbia

Institute of Lung Diseases and Tuberculosis, Clinical Centre of Serbia, Belgrade, Serbia

Institute of Hematology, Clinical Centre of Serbia, Belgrade, Serbia

Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia

Balkan Journal of Medical Genetics

Diagnosis of pulmonary thromboembolism (PTE) usually includes clinical pretest probability assessment, testing for specific degradation products of...

The Prothrombin Factor II G20210A Mutation with Pulmonary Thromboembolism and a Normal Level of Fibrin Degradation Products

Publicado en línea: 19 feb 2010

Páginas: 69 - 75

DOI: https://doi.org/10.2478/v10034-010-0007-7

Palabras clave
Surgical procedure, Thromboembolism, Cross-linked fibrin (D-dimer), Factor II (FII) G20210A mutation, Risk factor

This content is open access.

The Prothrombin Factor II G20210A Mutation with Pulmonary Thromboembolism and a Normal Level of Fibrin Degradation Products

Publicado en línea: 19 feb 2010

Páginas: 69 - 75

DOI: https://doi.org/10.2478/v10034-010-0007-7

Palabras claveSurgical procedure, Thromboembolism, Cross-linked fibrin (D-dimer), Factor II (FII) G20210A mutation, Risk factor

This content is open access.

Palabras clave
Surgical procedure, Thromboembolism, Cross-linked fibrin (D-dimer), Factor II (FII) G20210A mutation, Risk factor