<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p><bold>Background.</bold> Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5-20% of all gliomas.</p><p><bold>Conclusions.</bold> Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher sensitivity to treatment. Additionally, 1p and 19q loss is a marker of clinical utility, helping to assess tumour sensitivity to chemotherapy and harbouring the potential for improving the diagnosis and survival of oligodendroglioma patients as well as future clinical practice.</p></abstract>

Background. Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5-20% of all gliomas.Conclusions. Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher sensitivity to treatment. Additionally, 1p and 19q loss is a marker of clinical utility, helping to assess tumour sensitivity to chemotherapy and harbouring the potential for improving the diagnosis and survival of oligodendroglioma patients as well as future clinical practice.

Genetic markers in oligodendroglial tumours

Department of Neurosurgery, University Medical Centre Maribor, Maribor, Slovenia

Institute of Oncology Ljubljana, Ljubljana, Slovenia

Department of Pathology, Medical Faculty Ljubljana, Ljubljana, Slovenia

Radiology and Oncology

{"article-title":"Genetic markers in oligodendroglial tumours"}

Background. Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour,...

Genetic markers in oligodendroglial tumours

Publicado en línea: 18 mar 2010

Páginas: 13 - 18

DOI: https://doi.org/10.2478/v10019-010-0007-y

Palabras clave
oligodendroglioma, genetic markers, chemotherapy, prognosis

This content is open access.

Genetic markers in oligodendroglial tumours

Publicado en línea: 18 mar 2010

Páginas: 13 - 18

DOI: https://doi.org/10.2478/v10019-010-0007-y

Palabras claveoligodendroglioma, genetic markers, chemotherapy, prognosis

This content is open access.

Palabras clave
oligodendroglioma, genetic markers, chemotherapy, prognosis