Impact of superdisintegrants on efavirenz release from tablet formulations

S. Sathigari, G. Chadha, Y-H. Lee, N. Wright, D. Parsons, V. Rathnagiri, O. Fasina and R. Babu, Physicochemical characterization of efavirenz-cyclodextrin inclusion complexes, AAPS Pharm-SciTech. 10 (2009) 81-87; DOI: 10.1208/S12249-008-9180-3.10.1208/s12249-008-9180-3Search in Google Scholar

K. Kesavan, V. U. Rao, K. Bindu, P. S. Rajinikanth, J. K. Pandit and J. Balasubramaniam, Immediate release tablets of valsartan and efavirenz: Role of concentration of superdisintegrant, Ars. Pharm. 49 (2008) 229-243.Search in Google Scholar

W. T. Makooi-Morehead, J. D. Buehlar and B. R. Landmann, Formulation of fast-dissolving efavirenz capsules or tablets using super-disintegrants, US Pat. 6,238,695 B1, 29 May 2001; http://www.freepatentsonline.com/65551333.html/Search in Google Scholar

N. Zhao and L. L. Augsburger, The influence of swelling capacity of superdisintegrants in different pH media on the dissolution of hydrochlorothiazide from directly compressible tablets, AAPS PharmSciTech. 6 (2005) E120-126.10.1208/pt060119Search in Google Scholar

Food and Drug Administration Department, Efavirenz http://www.accessdata.fda.gov/scripts/cder/dissolution/dsp_SearchResults_Dissolutions.cfm?PrintAll=1Search in Google Scholar

J. Balasubramaniam, K. Bindu, V. U. Rao, D. Ray, R. Haldar and A. W. Brzeczko, Effect of superdisintegrants on dissolution of cationic drugs, Dissol. Technol. 15 (2008) 18-25.10.14227/DT150208P18Search in Google Scholar

M. S. Gordon, V. S. Rudraraju, K. Dani and Z. T. Chowhan, Effect of the mode of superdisintegrants incorporation on dissolution in wet granulated tablets, J. Pharm. Sci. 82 (1993) 220-226.10.1002/jps.2600820222Search in Google Scholar

B. Preetha, J. K. Pandit, V. U. Rao, K. Bindu, Y. V. Rajesh and J. Balasubramaniam, Comparative evaluation of mode of incorporation of superdisintegrants on dissolution of model drugs from wet granulated tablets, Acta Pharm. Sci. 50 (2008) 229-236.Search in Google Scholar

Y. S. Yen, C. R. Chen, M. T. Lee and L. C. Chen, Investigation of dissolution enhancement of nifedipine by deposition on superdisintegrants, Drug. Dev. Ind. Pharm. 23 (1997) 313-317; DOI: 10.3109/03639049709149809.10.3109/03639049709149809Search in Google Scholar

J. Kukura, J. L. Baxter and F. J. Muzzio, Shear distribution and variability in the USP apparatus 2 under turbulent conditions, Int. J. Pharm. 279 (2004) 9-17; DOI: 10.1016/j.ijpharm.2004.03.033.10.1016/j.ijpharm.2004.03.033Search in Google Scholar

L. G. McCarthy, C. Kosiol, A. M. Healy, G. Bradley, J. C. Sexton and O. I. Corrigan, Simulating the hydrodynamic conditions in the United States Pharmacopeia paddle dissolution apparatus, AAPS Pharm. Sci.Tech. 4 (2005) 1-16.Search in Google Scholar

S. A. Qureshi and J. Shabnam, Cause of high variability in drug dissolution testing and its impact on setting tolerances, Eur. J. Pharm. Sci. 12 (2001) 271-276; DOI: 10.1016/S0928-0987(00)00174-3.10.1016/S0928-0987(00)00174-3Search in Google Scholar

S. A. Qureshi, Developing discriminatory drug dissolution tests and profiles: Some thoughts for consideration on the concept and its interpretation, Dissol. Technol. 13 (2006) 18-23.Search in Google Scholar

M. S. Kim, S. J. Jin, J. S. Kim, H. J. Park, H. S. Song, R. H. H. Neubert and S. J. Hwang, Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process, Eur. J. Pharm. Biopharm. 69 (2008) 454-465; DOI: 10.1016/j.ejpb.2008.01.007.10.1016/j.ejpb.2008.01.00718359211Search in Google Scholar