<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-<italic>b</italic>)indoles <bold>4a-j, 5a-j</bold> and <bold>6a-j</bold> has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of <italic>N</italic>-alkyl indole-3-carbox-aldehydes <bold>1a-j, 2a-j</bold> and <bold>3a-j</bold> with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.</p></abstract>

A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carbox-aldehydes 1a-j, 2a-j and 3a-j with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.

Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-ary1-8-alkyl pyrazolo(3,4-<italic>b</italic>)indoles

Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt

Organic Chemistry NWII, 1/2, University of Bayreuth, Bayreuth, Germany

Research Unit, Egypt Pharmacist Co., Cairo, Egypt

Acta Pharmaceutica

Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-ary1-8-alkyl pyrazolo(3,4-)indoles

A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and...

Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-ary1-8-alkyl pyrazolo(3,4-b)indoles

Publicado en línea: 13 mar 2010

Páginas: 73 - 88

DOI: https://doi.org/10.2478/v10007-010-0009-8

Palabras clave
indol-3-karboksaldehid, protuupalno djelovanje, antikonvulzivno djelovanje, analgetsko djelovanje

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