<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Various <italic>N</italic>-(5-chloro-6-substituted-benzothiazol-2-yl)-<italic>N'</italic>-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (<bold>5a-t</bold>) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium. Interestingly, all the compounds showed protections against seizures in the range 50-100% indicative of the promising nature of the compounds against seizure spread. Compounds <bold>5b</bold> and <bold>5c</bold> showed complete protection against MES induced seizures.</p></abstract>

Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium. Interestingly, all the compounds showed protections against seizures in the range 50-100% indicative of the promising nature of the compounds against seizure spread. Compounds 5b and 5c showed complete protection against MES induced seizures.

Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India

Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India

Department of Biochemistry, Faculty of Medicine, 7th October University, Misurata, Libya

Acta Pharmaceutica

Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from...

Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity

Publicado en línea: 16 nov 2009

Páginas: 441 - 451

DOI: https://doi.org/10.2478/v10007-009-0031-x

Palabras clave
benzotiazol, tiadiazol, antikonvulziv, neurotoksičnost, hepatotoksičnost

This content is open access.

Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity

Publicado en línea: 16 nov 2009

Páginas: 441 - 451

DOI: https://doi.org/10.2478/v10007-009-0031-x

Palabras clavebenzotiazol, tiadiazol, antikonvulziv, neurotoksičnost, hepatotoksičnost

This content is open access.

Palabras clave
benzotiazol, tiadiazol, antikonvulziv, neurotoksičnost, hepatotoksičnost