The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: Synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities

A. Bolognese, G. Correale, M. Manfra, A. Lavecchia, E. Novellino and S. Pepe, Antitumor agents. 5. Synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-benzopyridophenoxazin-5-ones with potent antiproliferative activity, J. Med. Chem. 49 (2006) 5110-5118; DOI: 10.1021/jm0507451.Search in Google Scholar

G. Heimer, M. Rivlin-Etzion, I. Bar-Gad, J. A. Goldberg, S. N. Haber and H. Bergman, Dopamine replacement therapy does not restore the full spectrum of normal pallidal activity in the 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine primate model of Parkinsonism, J. Neurosci. 26 (2006) 8101-8114; DOI: 10.1523/JNEUROSCI.5140-05.2006.10.1523/JNEUROSCI.5140-05.2006667378116885224Search in Google Scholar

R. Powers, J. C. Copland, K. Germer, K. A. Mercier, V. Ramanathan and P. Revesz, Comparison of protein active site structures for functional annotation of proteins and drug design, Proteins 65 (2006) 124-135; DOI: 10.1002/prot.21092.10.1002/prot.2109216862592Search in Google Scholar

F. M. Abdelrazek, F. A. Micheal and A. E. Mohamed; Synthesis and molluscicidal activity of some 1,3,4-triaryl-5-chloropyrazole, pyrano[2,3-c]pyrazole, pyrazolylphthalazine and pyrano[2,3-d]thiazole derivatives, Arch. Pharm. (Weinheim) 339 (2006) 305-312; DOI: 10.1002/ardp.200500259.10.1002/ardp.20050025916649159Search in Google Scholar

F. M. Abdelrazek and A. D. Fathy, A novel synthesis and molluscicidal activity of some functionally substituted pyridine, pyrido[3,2-c]pyridazine, and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives, Arch. Pharm. (Weinheim) 338 (2005) 329-334; DOI: 10.1002/ardp.200400938.10.1002/ardp.20040093815981299Search in Google Scholar

S. Alias, R. Andreu, M. A. Cerdan, S. Franco, J. Garin, J. Orduna, P. Romero and B. Villacampa, Synthesis, characterization and optical properties of merocyanines derived from malononitrile dimer, Tetrahedron Lett. 48 (2007) 6539-6542; DOI: 10.1016/j.tetlet.2007.07.048.10.1016/j.tetlet.2007.07.048Search in Google Scholar

L. K. Wing, H. A. Behanna, L. J. Van Eldik, D. M. Watterson and R. H. Ralay, De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders, Curr. Alzheimer Res. 3 (2006) 205-214; DOI: 10.2174/156720506777632844.10.2174/15672050677763284416842097Search in Google Scholar

E. Rozsa, H. Obotka, D. Nagy, T. Farkas, K. Saa, L. Vecsei and J. Toldi, The pentylenetetrazole-iduced acivity in the hippocampus can be inhibited by the conversion of 1-kynurenine to kynurenic acid: an in vitro study, Brain Res. Bull. 76 (2008) 474-479; DOI: 10.1016/j.brainresbull.2007.12.001.10.1016/j.brainresbull.2007.12.00118534254Search in Google Scholar

E. Szarics, A. Simon, J. Visy, E. Simon-Trompler, Z. Banka, L. Heja, L. G. Harsing, G. Blasco, J. Kardos, L. Jeja, L. G. Harsing, G. Blasco and J. Kardos, Cyclothiazide binding to the GABAA receptor, Neurosci. Lett. 439 (2008) 66-69; DOI: 10.1016/j.neulet.2008.04.092.10.1016/j.neulet.2008.04.09218502046Search in Google Scholar

K. Odlo, J. Hentzen, J. F. Chabert, S. Ducki, O. A. Gani, I. Sylte, M. Skrede, V. A. Florenes and T. V. Hanse, 1,5-Disubstituted 1,2,3-triazole as cis-restricted analogues of combrestastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin, Bioorg. Med. Chem. 16 (2008) 4829-4838; DOI: 10.1016/j.bmc.2008.03.049.10.1016/j.bmc.2008.03.04918396050Search in Google Scholar

H. Zhao, M. D. Serby, Z. Xin, B. G. Szczepankiewicz, M. Liu, C. Kosogof, B. Liu, L. T. Nelson, E. F. Johnson, S. Wang, T. Pederson, R. J. Gum, J. E. Clampit, D. L. Haasch, C. Abad-Zapatero, E. H. Fry, C. Rondinone, J. M. Trevillyan, H. L. Sham and G. Liu, Discovery of potent highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors, J. Med. Chem. 27 (2006) 4455-4458; DOI: 10.1021/jm0604651.Search in Google Scholar

K. Muranaka, A. Sano, S. Ichikawa and A. Mastsuda, Synthesis of Hsp89 inhibitor dimmers as potential antitumer agents, Bioorg. Med. Chem. 16 (2008) 5862-5870; DOI: 10.1016/j.bmc.2008.04.070.10.1016/j.bmc.2008.04.07018487051Search in Google Scholar

A. Burguete, E. Pontiki, D. H. Litina, R. Villar, E. Vicente, B. Solano, S. Ancizu, S. Silanes, I. Aldana, A. Monge, Y. Maruyama, K. Anami and Y. Kotoh, Synthesis and anti-flammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinioxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues, Bioorg. Med. Chem. Lett. 17 (2007) 6439-6443; DOI: 10.1016/j.bmcl.2007.10.002.10.1016/j.bmcl.2007.10.002Search in Google Scholar

Y. Hirokawa, H. Kinoshita, T. Tanaka, T. Nakamura, K. Fujimoto, S. Kashimoto, T. Kojima and S. Kato, Pleuromutilin derivatives having a putine ring. Part 1: new compounds with promising antibacterial activity against resistant Gram-positive pathogens, Bioorg. Med. Chem. Lett. 18 (2008) 3556-3561; DOI: 10.1016/j.bmcl.2008.05.011.10.1016/j.bmcl.2008.05.011Search in Google Scholar

A. M. Palmer, B. Grobbel, C. Brehm, P. J. Zimmermann, W. Buhr, M. O Feth, H. C. Holst and W. A. Simon, Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion, Bioorg. Med. Chem. 15 (2007) 7647-7660; DOI: 10.1016/j.bmc.2007.08.065.10.1016/j.bmc.2007.08.065Search in Google Scholar

R. Leon, C. Rois, J. M. Contelles, M. G. Lopez, A. G. Barcia and M. Villaroya, Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death, Eur. J. Med. Chem. 43 (2008) 668-674; DOI: 10.1016/j.ejmech.2007.06.001.10.1016/j.ejmech.2007.06.001Search in Google Scholar

J. Z. Yang, Y. Chen, A. M. Zhu, Q. L. Liu and J. Y. Wu, Analyzing diffusion behaviour of methanol/water through MFI membranes by molecular simulation, J. Membrane Sci. 328 (2008) 327-333; DOI: 10.1016/j.memsci.2008,02,059.Search in Google Scholar

Y. Z. Povstenko, Fractional radial diffusion ion in a cylinder, J. Mol. Liquids, 137 (2008) 46-50; DOI: 10.1016/j.molliq.2007,03.006.Search in Google Scholar

H. Sterk and M. Mittelbach, The relaxational behaviour of nitrile groups, J. Mag. Res. 62 (1985) 175-181; DOI: 10.1016/0022-2364(85)90051-4.10.1016/0022-2364(85)90051-4Search in Google Scholar

B. P. McKibben, C. H. Cartwright and A. L. Castelhano, Practicle synthesis of tetrasubstituted thiophenes for use in compound libraries, Tetrahedron Lett. 40 (1999) 5471-5474; DOI: 10.1016/S0040-4039(99)01108-9.10.1016/S0040-4039(99)01108-9Search in Google Scholar

P. Milart, J. Wilamowski and J. J. Sepiol, Synthesis of di- and triamino-1,1':3",1"-terphenyls from arylethylidene- and arylidenemalonodinitriles, Tetrahedron 54 (1998) 15643-15656; DOI: 10.1016/S0040-4020(98)00978-8.10.1016/S0040-4020(98)00978-8Search in Google Scholar