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2-Amino-5-sulfanyl-1,3,4-thiadiazoles: A new series of selective cyclooxygenase-2 inhibitors

M. C. Allison, A. G. Howastan, C. J. Torrance, F. D. Lee and R. N. Russell, Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs, Engl. J. Med. 327 (1982) 749-754.10.1056/NEJM199209103271101Search in Google Scholar

D. Bohl, H. Gaussmann, G. Vorberg, J. Sanch, R. Garcia-Barbal, J. F. Sarti and F. J. J. Harrison, A clinical trial comparing a new NSAID: Droxicam and proxicam in spinal osteoarthritis, Int. J. Clin. Pharmacol. Ther. Toxic. 28 (1990) 416-419.Search in Google Scholar

R. S. Shelley and Y. Wei, Solutions of Aryl or Heteroaryl Substituted Alkanoic Acids in Lipophilic Solvents and Soft Gelatin Capsules Containing Such Solutions, Eur. Pat. Pub., 30 Nov. 1995, WO, 9531979, 1994.Search in Google Scholar

K. Chegaev, L. Lazzarato, P. Tosco, C. Cena, E. Marini, B. Rolando, P. A. Carrupt, R. Fruttero and A. Gasco, NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilatory properties, J. Med. Chem. 50 (2007) 1449-1457; DOI: 10.1021/jm0607247.10.1021/jm0607247Search in Google Scholar

M. Biava, G. C. Porretta, G. Poce, S. Supino, S. Forli, M. Rovini, A. Cappelli, F. Manetti, M. Botta, L. Sautebin, A. Rossi, C. Pergola, C. Ghelardini, E. Vivoli, F. Makovec, P. Anzellotti, P. Patrignani and M. Anzini, Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity, J. Med. Chem. 50 (2007) 5403-5411; DOI: 10.1021/jm0707525.10.1021/jm0707525Search in Google Scholar

J. P. Waldo and R. C. Larock, The synthesis of highly substituted isoxazoles by electrophilic cyclization: An efficient synthesis of valdecoxib, J. Org. Chem. 72 (2007) 9643-9647; DOI: 10.1021/jo701942e.10.1021/jo701942eSearch in Google Scholar

J. R. Vane, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs, Nature (New Biol.) 231 (1971) 232-235.10.1038/newbio231232a0Search in Google Scholar

J. A. Mitchell, P. Akaraseenont, C. Themermann, R. J. Flower, J. R. Vane, Selectivity of non steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase, Proc. Natl. Acd. Sci. USA. 90 (1993) 11693-11697.10.1073/pnas.90.24.11693Search in Google Scholar

R. Sharma and S. C. Chaturvedi, Development of pharmacophoric models on 5,6-diarylimidaxo-[2,1-b]-thiazole for selective cyclooxygenase-2 inhibitors, Indian J. Pharm. Sci. 66 (2004) 758-772.Search in Google Scholar

R. Sharma, S. C. Chaturvedi and A. K. Saxena, 3D-QSAR studies on novel terphenyls for selective inhibition of cyclooxygenase-2 enzyme, Indian J. Pharm. Sci. 66 (2004) 758-772.Search in Google Scholar

F. Clerici and D. Pocar, Synthesis of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives and evaluation of their antidepressant and anxiolytic activity, J. Med. Chem. 44 (2001) 931-936; DOI: 10.1021/jm001027w.10.1021/jm001027wSearch in Google Scholar

R. J. Kulmacz and W. E. M. Lands, Requirements for hydro peroxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase, Prostaglandins 25 (1983) 531-540.10.1016/0090-6980(83)90025-4Search in Google Scholar

Colorimetric COX (ovine) inhibitor screening assay, Catalog No. 760111, Cayman Chemical, Ann Arbor (MI) 2005.Search in Google Scholar

C. A. Winter, E. A. Risely and G. N. Nuss, Carrageenean-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. 111 (1962) 544-547.10.3181/00379727-111-2784914001233Search in Google Scholar

H. G. Vogel, Drug Discovery and Evaluation Pharmacological Assays, Springer, Frankfurt 2002, pp. 694.Search in Google Scholar

R. R Ranatunge, M. Augustyniak, U. K. Bandarage, R. A. Earl, J. L. Ellis, D. S. Garvey, D. R. Janero, L. G. Letts, A. M. Martino, M. G Murty, S. K. Richardson, J. D. Schroeder, M. J. Shumway, S. W. Tam, A. M. Trocha and D. V. Young, Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor containing pyrazoles, J. Med. Chem. 47 (2004) 2180-2193; DOI: 10.1021/jm0302769.Search in Google Scholar

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1330-0075
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4 veces al año
Temas de la revista:
Pharmacy, other