<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Hepatoprotective activity of the ethyl acetate extract of <italic>Teucrium polium</italic> L. was investigated using rats with CCl4--induced liver damage. Specific biochemical parameters (glutathione peroxidase, superoxide dismutase, reduced glutathione and total antioxidative status) were estimated in blood and in liver homogenate. Lipid peroxidation in CCl4--intoxicated rats was evidenced by a marked increment in the levels of thiobarbituric acid reactive substances. Histopatological examinations of the liver were undertaken to monitor the liver status. Silymarin was used as a standard to compare the hepatoprotective activity of the extract. Some biochemical parameters in groups treated with the <italic>Teucrium polium</italic> extract at a dose of 25 mg kg-1, showed significantly different values than that of the CCl4--treated group. The liver biopsy of all experimental rat groups treated with the <italic>Teucrium polium</italic> ethyl acetate extract showed significant restoration of the normal histomorphological pattern of liver cells. The study substantiates the potential hepatoprotective activity of the ethyl acetate extract of <italic>Teucrium polium</italic> L.</abstract>

Hepatoprotective activity of the ethyl acetate extract of Teucrium polium L. was investigated using rats with CCl4--induced liver damage. Specific biochemical parameters (glutathione peroxidase, superoxide dismutase, reduced glutathione and total antioxidative status) were estimated in blood and in liver homogenate. Lipid peroxidation in CCl4--intoxicated rats was evidenced by a marked increment in the levels of thiobarbituric acid reactive substances. Histopatological examinations of the liver were undertaken to monitor the liver status. Silymarin was used as a standard to compare the hepatoprotective activity of the extract. Some biochemical parameters in groups treated with the Teucrium polium extract at a dose of 25 mg kg-1, showed significantly different values than that of the CCl4--treated group. The liver biopsy of all experimental rat groups treated with the Teucrium polium ethyl acetate extract showed significant restoration of the normal histomorphological pattern of liver cells. The study substantiates the potential hepatoprotective activity of the ethyl acetate extract of Teucrium polium L.

Hepatoprotective effect of the ethyl acetate extract of <italic>Teucrium polium</italic> L. against carbontetrachloride-induced hepatic injury in rats

Institute of Toxicology Faculty of Pharmacy, University »Ss. Cyril and Methodius«, 1000 Skopje, Republic of Macedonia

Institute of Pharmacognosy Faculty of Pharmacy, University »Ss. Cyril and Methodius«, 1000 Skopje, Republic of Macedonia

Institute of Biology Faculty of Natural Sciences and Mathematics, University »Ss. Cyril and Methodius«, P. B. 126, 1000 Skopje Republic of Macedonia

Clinical Center, Institute of Clinical Biochemistry, 1000 Skopje Republic of Macedonia

Institute of Pathology, University »Ss. Cyril and Methodius«, 1000 Skopje, Republic of Macedonia

Acta Pharmaceutica

Hepatoprotective effect of the ethyl acetate extract of  L. against carbontetrachloride-induced hepatic injury in rats

Hepatoprotective activity of the ethyl acetate extract of Teucrium polium L. was investigated using rats with CCl4--induced liver damage. Specific biochemical...

Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

Publicado en línea: 16 may 2007

Páginas: 241 - 248

DOI: https://doi.org/10.2478/v10007-007-0020-x

Palabras clave
hepatoprotektivni učinak, tetraklormetan, silimarin, glutation

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