Red Blood Cell Acetylcholinesterase and Plasma Butyrylcholinesterase Status: Important Indicators for the Treatment of Patients Poisoned by Organophosphorus Compounds

Tu AT. Chemical terrorism: horrors in Tokyo subway and Matsumoto city. Fort Collins: Alaken Inc.; 2002.Search in Google Scholar

Eyer P. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicol Rev 2003;22:165-90.10.2165/00139709-200322030-00004Search in Google Scholar

Lotti M. Clinical toxicology of anticholinesterase agents in humans. In: Krieger RI, editor. Handbook of Pesticide Toxicology. 2^nd ed. San Diego, San Francisco, New York, Boston, London, Sydney, Tokyo: Academic Press; 2001. p. 1043-85.10.1016/B978-012426260-7.50054-9Search in Google Scholar

Aaron CK, Howland MA. Insecticides: organophosphates and carbamates. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, editors. Toxicologic Emergencies. 5^th ed. Norwalk, Connecticut: Appleton & Lange; 1994. p. 1105-16.Search in Google Scholar

Eddleston M, Buckley NA, Checketts H, Senarathna L, Mohamed F, Sheriff MH, Dawson A. Speed of initial atropinisation in significant organophosphorus pesticide poisoning-a systematic comparison of recommended regimens. J Toxicol Clin Toxicol 2004;42:865-75.10.1081/CLT-200035223Search in Google Scholar

Wilson IB, Ginsburg S. A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase. Biochem Biophys Acta 1955;18:168-70.10.1016/0006-3002(55)90040-8Search in Google Scholar

Namba T, Hiraki K. PAM (Pyridine-2-aldoxime methiodide) therapy for alkylphosphate poisoning. JAMA 1958;166:1834-9.10.1001/jama.1958.02990150030007Search in Google Scholar

Erdmann WD, Clarmann M. Ein neuer Esterase-Reaktivator für die Behandlung von Vergiftungen mit Alkylphosphaten [A new esterase reactivator for the treatment of alkylphosphate poisoning, in German]. Deutsch Med Wochenschr 1963;45:2201-7.Search in Google Scholar

Sundwall A. Minimum concentrations of N-methylpyridinium-2-aldoxime methane sulphonate (P2S) which reverse neuromuscular block. Biochem Pharmacol 1961;8:413-7.10.1016/0006-2952(61)90059-4Search in Google Scholar

Worek F, Thiermann H, Szinicz L, Eyer P. Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. Biochem Pharmacol 2004;68:2237-48.10.1016/j.bcp.2004.07.038Search in Google Scholar

Thiermann H, Szinicz L, Eyer F, Worek F, Eyer P, Felgenhauer N, Zilker T. Modern strategies in therapy of organophosphate poisoning. Toxicol Lett 1999;107:233-9.10.1016/S0378-4274(99)00052-1Search in Google Scholar

Worek F, Reiter G, Eyer P, Szinicz L. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Arch Toxicol 2002;76:523-9.10.1007/s00204-002-0375-112242610Search in Google Scholar

Eyer P. Optimal oxime dosage regimen, a pharmacokinetic approach. In: Szinicz L, Eyer P, Klimmek R, editors. Role of Oximes in the Treatment of Anticholinesterase Agent Poisoning. Heidelberg. Berlin, Oxford: Spektrum Akademischer Verlag; 1996. p. 33-51.Search in Google Scholar

Eyer P. Use of obidoxime in OP poisoning. Hum Exp Toxicol 1996;15:78.Search in Google Scholar

Eyer P, Szinicz L, Thiermann H, Worek F, Zilker T. Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality. Toxicology 2007;233:108-19.10.1016/j.tox.2006.08.03317010492Search in Google Scholar

Thiermann H, Mast U, Klimmek R, Eyer P, Hibler A, Pfab R, Felgenhauer N, Zilker T. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum Exp Toxicol 1997;16:473-80.10.1177/096032719701600809Search in Google Scholar

Worek F, Baecker M, Thiermann H, Szinicz L, Mast U, Klimmek R, Eyer P. Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum Exp Toxicol 1997;16:466-72.10.1177/096032719701600808Search in Google Scholar

Worek F, Szinicz L, Eyer P, Thiermann H. Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model. Toxicol Appl Pharmacol 2005;209:193-202.10.1016/j.taap.2005.04.006Search in Google Scholar

Worek F, Eyer P, Szinicz L, Thiermann H. Simulation of cholinesterase status at different scenarios of nerve agent exposure. Toxicology 2007;233:155-65.10.1016/j.tox.2006.07.002Search in Google Scholar

Thiermann H, Szinicz L, Eyer P, Felgenhauer N, Zilker T, Worek F. Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning. Toxicology 2007;233:145-54.10.1016/j.tox.2006.11.056Search in Google Scholar

Pawar KS, Bhoite RR, Pillay CP, Chavan SC, Malshikare DS, Garad SG. Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial. Lancet 2006;368:2136-41.10.1016/S0140-6736(06)69862-0Search in Google Scholar

Worek F, Mast U, Kiderlen D, Diepold C, Eyer P. Improved determination of acetylcholinesterase activity in human whole blood. Clin Chim Acta 1999;288:73-90.10.1016/S0009-8981(99)00144-8Search in Google Scholar

Thiermann H, Szinicz L, Eyer P, Zilker T, Worek F. Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning. Chem Biol Interact 2005;157-158:345-7.10.1016/j.cbi.2005.10.102Search in Google Scholar

Eddleston M, Eyer P, Worek F, Mohamed F, Senarathna L, von Meyer L, Juszczak E, Hittarage A, Azhar S, Dissanayake W. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet 2005;366:1452-9.10.1016/S0140-6736(05)67598-8Search in Google Scholar

Pfeiffer B. Vergiftungen durch Organophosphate I. MTA Dialog 2005;6:583-5.Search in Google Scholar

Pfeiffer B. Analyzing cholinesterase in organophosphate poisoning. Tecan J 2006;2:22-3.Search in Google Scholar

Eberly JP, Eyer P, Pfeiffer B, Szincz L, Worek F. Modification of the Test-mate ChE cholinesterase test system for use over an extended temperature range. Medical Defense Bioscience Review 2004;1-11.Search in Google Scholar

Eyer F, Meischner V, Kiderlen D, Thiermann H, Worek F, Haberkorn M, Flegenhauer N, Zilker T, Eyer P. Human parathion poisoning. Toxicol Rev 2003;22:143-63.10.2165/00139709-200322030-0000315181664Search in Google Scholar

Eyer F, Eyer P. Enzyme-based assay for quantification of paraoxon in blood of parathion poisoned patients. Hum Exp Toxicol 1998;17:645-51.10.1177/096032719801701201Search in Google Scholar

Wolthuis O, Vanwersch RA, van der Wiel HJ. The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man. Eur J Pharmacol 1981;70:355-69.10.1016/0014-2999(81)90169-2Search in Google Scholar

Smith AP, van der Weil HJ, Wolthuis OL. Analysis of oxime-induced neuromuscular recovery in guinea-pig, rat and man following soman poisoning in vitro. Eur J Pharmacol 1981;70:371-9.10.1016/0014-2999(81)90170-9Search in Google Scholar

van der Meer C, Wolthuis OL. The effect of oximes on isolated organs intoxicated with organophosphorus anticholinesterases. Biochem Pharmacol 1965;14:1299-312.10.1016/0006-2952(65)90117-6Search in Google Scholar

van Helden HP, van der Wiel HJ, Wolthuis OL. Retention of soman in rats, guinea-pigs and marmosets: species-dependent effects of the soman simulator, pinacolyl dimethylphosphinate (PDP). J Pharm Pharmacol 1988;40:35-41.10.1111/j.2042-7158.1988.tb05146.xSearch in Google Scholar

van Helden HP, van der Wiel HJ, de Lange J, Busker RW, Melchers BP, Wolthuis OL. Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys. Toxicol Appl Pharmacol 1992;115:50-6.10.1016/0041-008X(92)90366-ZSearch in Google Scholar

Alberts P. A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro. Eur J Pharmacol 1990;184:191-4.10.1016/0014-2999(90)90682-VSearch in Google Scholar

Thiermann H, Eyer P, Worek F, Szinicz L. Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. Toxicol 2005;214:190.10.1016/j.tox.2005.06.01316040183Search in Google Scholar

Maselli RA, Leung C. Analysis of anticholinesterase-induced neuromuscular transmission failure. Muscle Nerve 1993;16:548-53.10.1002/mus.8801605188390609Search in Google Scholar

Besser R, Gutmann L, Dillmann U, Weilemann LS, Hopf HC. End-plate dysfunction in acute organophosphate intoxication. Neurology 1989;39:561-7.10.1212/WNL.39.4.561Search in Google Scholar

Massoulie J, Pezzementi L, Bon S, Krejci E, Vallette FM. Molecular and cellular biology of cholinesterases. Prog Neurobiol 1993;41:31-91.10.1016/0301-0082(93)90040-YSearch in Google Scholar

Brimijoin S. Molecular forms of acetylcholinesterase in brain, nerve and muscle: nature, localization and dynamics. Prog Neurobiol 1983;21:291-322.10.1016/0301-0082(83)90015-1Search in Google Scholar

Mortensen SR, Brimijoin S, Hooper MJ, Padilla S. Comparison of the in vitro sensivitiy of rat acetylcholinesterase to chlorpyrifos-oxon: What do tissue IC50 values represent? Toxicol Appl Pharmacol 1998;148:46-9.10.1006/taap.1997.8287Search in Google Scholar

Namba T, Nolte CT, Jackrel J, Grob D. Poisoning due to organophosphate insecticides. Acute and chronic manifestations. Am J Med 1971;50:475-92.10.1016/0002-9343(71)90337-8Search in Google Scholar

Brank M, Zajc-Kreft K, Kreft S, Komel R, Grubic Z. Biogenesis of acetylcholinesterase is impaired, although its mRNA level remains normal, in the glucocorticoid-treated rat skeletal muscle. Eur J Biochem 1998;251:374-81.10.1046/j.1432-1327.1998.2510374.xSearch in Google Scholar

Grubic Z, Sketelj J, Klinar B, Brzin M. Recovery of acetylcholinesterase in the diaphragm, brain, and plasma of the rat after irreversible inhibition by soman: a study of cytochemical localization and molecular forms of the enzyme in the motor end plate. J Neurochem 1981;37:909-16.10.1111/j.1471-4159.1981.tb04478.xSearch in Google Scholar

Worek F, Eyer P, Szinicz L. Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases. Arch Toxicol 1998;72:580-7.10.1007/s002040050546Search in Google Scholar

Spöhrer U, Eyer P. Separation of geometrical syn and anti isomers of obidoxime by ion-pair high-performance liquid chromatography. J Chromatogr A 1995;693:55-61.10.1016/0021-9673(94)01012-4Search in Google Scholar