Acceso abierto

A Study to Compare Hypolipidemic Effects of Allium Sativum (Garlic) Alone and in Combination with Atorvastatin or Ezetimibe in Experimental Model


Cite

1. Thomas PB. Drug Therapy for Hypercholesterolemia and Dyslipidemia. In: Laurence LB, Bruce AC Björn CK, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. SunDieogo: McGraw Hill; 2012.p. 877-906. Search in Google Scholar

2. Gu B, You J, Li YP and Yuan QL. Supplementation of Enteric-coated Ginger and Garlic Essence Tablet Improved Blood Lipid Profile in Rats Fed High-fat Diet and Hyperlipidemic Subjects. Food Sci. Technol. Res. 2011; 17(5): 409-14. Search in Google Scholar

3. Maheswari G. Investigation of effect of garlic extract on the hypolipidemic effect of ezetimibe. Pharmacologyonline. 2011; 2: 291-95. Search in Google Scholar

4. Gupta V. Hypolipidemic Effect of Fenugreek and Garlic on Experimentally Induced Hyperlipidemia in Rabbits: A Randomized Control Trial. International Journal of Basic and Applied Physiology; 2(1): 193. Search in Google Scholar

5. Aka LO. The effects of dietary supplementation of Allium sativum on some vital biochemical parameters in male Albino rats. Sokoto Journal of Veterinary Sciences. 2010; 8(1): 26-30. Search in Google Scholar

6. Shrivastava A, Chaturvedi U, Singh SV, Saxena JK, Bhatia G. A mechanism based pharmacological evaluation of efficacy of Allium sativum in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats. Asian Journal of Pharmaceutical and Clinical Research. 2012; 5(3): 123-26. Search in Google Scholar

7. Ebesunun MO et al. The effect of garlic on plasma lipids and lipoproteins in rats fed on high cholesterol enriched diet. Biokemistri. 2007; 19(2): 53-58. Search in Google Scholar

8. Tanamai J, Veeramanomai S, Indrakosas N. The Efficacy of cholesterol-lowering action and side effects of Garlic enteric coated tablets in man. J Med Assoc Thai 2004; 87(10): 1156-61. Search in Google Scholar

9. Turner B, Molgaard C, Markmann P. Effect of Garlic (Allium Sativum) powder tablet on serum lipid, blood pressure and arterial stiffness in normolipidemic volunteers: a randomized double blind, placebo-controlled trial. Br J Nutr 2004; 92:701-610.1079/BJN20041255 Search in Google Scholar

10. Peleg A, Hershcocivi T, Lipa r, Anbar r, Redler M, Beigel Y. Effect of Garlic on lipid profiles psychopathologic parameters in people with mild to moderate hypercholesterolemia. Isr Med Assoc J 2003; 5(9): 637-40. Search in Google Scholar

11. Superko HR, Krauss RM. Garlic powder, effect on plasma lipids, postprandial lipemia, low density lipoprotein particle size, high density lipoprotein subclass distribution and lipoprotein (a). J Am Coll Cardiol 2000; 35(2): 321-6.10.1016/S0735-1097(99)90541-7 Search in Google Scholar

12. Syed Mohammed BasheeruddinAsdaq, “Antioxidant and Hypolipidemic Potential of Aged Garlic Extract and Its Constituent, S-Allyl Cysteine, in Rats,” Evidence- Based Complementary and Alternative Medicine, vol. 2015, Article ID 328545, 7 pages, 2015. https://doi.org/10.1155/2015/328545.10.1155/2015/328545 Search in Google Scholar

13. Gosaina S. Hypolipidemic effect of ethanolic extract from the leaves of hibiscus sabdariffa l. in hyperlipidemic rats. Acta PoloniaePharmaceutica ñ Drug Research. 2010; 67: 179-84. Search in Google Scholar

14. Maheshwari G, Pandey SP, Chandel HS, Chadoker A, Keservani RK, Sharma AK. Investigation of effect of garlic extract on the hypolipidemic effect of ezetimibe. Pharmacologyonline. 2011; 2: 291-95. Search in Google Scholar

15. Mohammadi A. The In Vivo Biochemical and Oxidative Change by Garlic and Ezetimibe Combination in Hypercholesterolemic Mice. International Research Journal of Biological Sciences. 2014; 3(4):47-51. Search in Google Scholar

16. Hamed, M &Hassanein, Nahed& Ali, Azza&Elnahhas, Toqa. (2010). An Experimental Study on the Therapeutic Efficacy of the Combined Administration of Herbal Medicines with Atorvastatin against Hyperlipidemia in Rats. 6. 1730-1744. Search in Google Scholar

17. Burden N, Chapman K, Sewell F, Robinson V. Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs). J Am Assoc Lab Anim Sci. 2015;54(2):198–208. Search in Google Scholar

18. Sampathkumar MT, Kasetti RB, Nabi SA, Sudarshan PR, Swapna S, Apparao C. Antihyperlipidemic and antiatherogenic activities of Terminalia pallida Linn. fruits in high fat diet-induced hyperlipidemic rats. J Pharm Bioallied Sci. 2011;3(3):449–452. doi:10.4103/0975-7406.8446410.4103/0975-7406.84464 Search in Google Scholar

19. Bagchi C, Tripathi SK, Hazra A, Bhattacharya D. Evaluation of Hypolipidemic Activity of Premnaintegrifolia Linn. Bark in Rabbit Model. Pharmbit.2008; 18(2): 149. Search in Google Scholar

20. Pfizer Ireland Pharmaceuticals. Lipitor (atorvastation) [package insert]. US Food and Drug Administration. Website.https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020702s056lbl.pdf. Revised November 2019.Accessed February 19, 2020. Search in Google Scholar

21. Merck/Schering-Plough Pharmaceuticals. Zetia (ezetimibe) [package insert] .US Food and Drug Administration. Website.https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021445s018lbl.pdf. Revised June 2007. Accessed February 19, 2020. Search in Google Scholar

22. Emmanuel UC and James O. Comparative Effects of Aqueous Garlic (Allium sativum) and Onion (Allium cepa) extracts on Some Haematological and Lipid Indices of Rats. Annual Review & Research in Biology. 2011; 1(3): 37-44. Search in Google Scholar

23. Asdaq SMB, Inamdar MN, Asad M. Effect of conventional antihypertensive drugs on hypolipidemic action of garlic in rats. Indian Journal of Experimental Biology. 2009; 47: 176-81. Search in Google Scholar

24. Ministry of Environment, Forest and Climate Change Government of India.Compendium of CPCSEA. New Delhi; CPCSEA; 2018. p. 62. Search in Google Scholar

25. University of Veterinarian and Animal Resouces. SOP: Blood Collection from the Tail Vein in Rats. [Cited 1 December 2019]. Avaialable from URL: Search in Google Scholar

26. https://ouv.vt.edu/content/dam/ouv_vt_edu/sops/smallanimal-biomedical/sop-rat-blood-collection-tailvein.pdf Search in Google Scholar

27. Reddy GD, Reddy GA, Rao GS, and Kumar MV. Pharmacokinetic interaction of garlic and atorvastatin in dyslipidemic rats. Indian Journal of Pharmacology. 2012 Mar- Apr; 44(2): 246–52.10.4103/0253-7613.93860 Search in Google Scholar

28. The University of British Colombia. Sops, Policies, And Guidelines. [Cited 1 December 2019]. Avaialable from URL: https://animalcare.ubc.ca/sites/default/files/documents/ACC-2012Tech09%20Oral%20Dosing%20%28Gavage%29%20in%20the%20Mouse%20and%20Rat%29%20Updated%20Feb%202015%20fnal_cc%2C%20ka.pdf. Search in Google Scholar

29. Yu-Yan Yeh, Lijuan Liu, Cholesterol-Lowering Effect of Garlic Extracts and Organosulfur Compounds: Human and Animal Studies, The Journal of Nutrition, Volume 131, Issue 3, March 2001, Pages 989S–993S, https://doi.org/10.1093/jn/131.3.989S.10.1093/jn/131.3.989S11238803 Search in Google Scholar

30. Yang C, Li L, Yang L, Lǚ H, Wang S, Sun G. Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet. NutrMetab (Lond). 2018; 15:43. Published 2018 Jun 20. doi:10.1186/s12986-018-0275-x. Search in Google Scholar

31. Sun YE, Wang W, Qin J. Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis. Medicine (Baltimore). 2018;97(18): e0255. doi:10.1097/MD.000000000001025510.1097/MD.0000000000010255 Search in Google Scholar

32. Kumar DS, Muthu AK, Smith AA, Manavalan R. Hypolipidemic effects of various effects of Whole plant of MucunaPruriens (Linn) in rat fed with high fat diet. European Journal of Biological Sciences. 2010; 2(2): 32-38. Search in Google Scholar

33. Krause BR, Newton RS. Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride- lowering in rats correlates with efficacy in LDL animal models. Atherosclerosis. 1995 Oct; 117(2): 237-44.10.1016/0021-9150(95)05576-I Search in Google Scholar

34. Rajyalakshmi G, Reddy A, Rajesham V. A Comparative Antihyperlipidemic Activity of Atorvastatin with Simvastatin in Rats. The Internet Journal of Pharmacology. 2008; 6(2).10.5580/203b Search in Google Scholar

35. Rajendran R and Krishnakumar E. Hypolipidemic Activity of Chloroform Extract of Mimosa pudica Leaves. AJMB. October-December 2010; 2(4): 215-22. Search in Google Scholar

36. Pillai KK, Chidambaranathana N, Halitha MM, Jayaprakasha S and Narayana N. Hypolipidemic activity of ethanolic extract of leaves of cnidoscoluschayamansa in hyperlipidemic models of wistar albino rats. Acta Chim. Pharm. Indica. 2012; 2(1): 24-31. Search in Google Scholar

37. Girija K, Lakshman K, Chandrika PU. Hypolipidemic effect of amaranthuscaudatus l. in triton wr-1339 induced hyperlipidemic rats. Pharmacologyonline. 2011; 1: 84-91. Search in Google Scholar

38. Eerike M, Arunachalam R, Yeddula VR, Konda VGR, Prasanth CR. Evaluation of Hypolipidemic Activity of Ethanolic and Aqueous Extracts of Fragaria Vesca in High Fat Diet Induced Hyperlipidemia in Rats. Int. J. Pharm. Sci. Rev. Res. September – October 2014; 28(2): 191-96. Search in Google Scholar

39. Yeh Y.Y. and Liu L, Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies, J Nutr. 2001; 131(3s), 989S-93S.10.1093/jn/131.3.989S Search in Google Scholar

40. Elmahdi B., Khalil MM and Abulgasim AI. The Effect of Fresh Crushed Garlic Bulbs (Allium sativum) on Plasma Lipids in Hypercholesterolemic Rats, Journal of Animal and Veterinary Sciences. 2008; 3: 15-19. Search in Google Scholar

41. Aouadi R. Effect of fresh garlic on lipid metabolism in male rats. Nutrition Research. 2000; 273-280.10.1016/S0271-5317(99)00159-1 Search in Google Scholar

42. Kim I et al. The beneficial effects of aged black garlic extract on obesity and hyperlipidemia in rats fed a highfat diet. Journal of Medicinal Plants Research. 2011; 5(14): 3159-68. Search in Google Scholar

43. Heeba GH, Abd-Elghany MI. Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats. Phytomedicine. 2010; 17(14):1076-81.10.1016/j.phymed.2010.04.00720576411 Search in Google Scholar

eISSN:
2335-075X
ISSN:
1820-8665
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicine, Clinical Medicine, other