1. bookVolumen 21 (2013): Edición 1 (March 2013)
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Revista
eISSN
2284-5623
ISSN
2284-5623
Primera edición
08 Aug 2013
Calendario de la edición
4 veces al año
Idiomas
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access type Acceso abierto

Carcinosarcoma of the breast with massive osseous malignant component: a basal-like entity with myoepithelial differentiation

Publicado en línea: 08 Aug 2013
Volumen & Edición: Volumen 21 (2013) - Edición 1 (March 2013)
Páginas: 67 - 73
Detalles de la revista
License
Formato
Revista
eISSN
2284-5623
ISSN
2284-5623
Primera edición
08 Aug 2013
Calendario de la edición
4 veces al año
Idiomas
Inglés
Abstract

We present the case of a 77 year old patient with a primary breast carcinosarcoma composed mostly of an osteogenic sarcoma of fibroblastic type in which only immunohistochemical analysis disclosed the presence of a minor malignant epithelial component. The malignant mesenchymal component derives from dedifferentiation of myoepithelial cells since myoepithelial markers are positive. Also, like the majority of the other metaplastic carcinomas in the breast, carcinosarcoma is a basal type of tumor that will not respond to endocrine drugs or Her2/neu therapy.

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Cuvinte cheie

1. Moinfar F.: Essentials of diagnostic breast pathologya practical approach. Springer; 2007: 234-236Search in Google Scholar

2. Ninomiya J, Oyama T, Horiguchi J, Koibuchi Y, Yoshida T, Iijima K et al: Two cases of breast cancer with cartilaginous and osseous metaplasia. Breast Cancer. 2005;12(1):52-6.10.2325/jbcs.12.5215657524Search in Google Scholar

3. Kijima Y, Umekita Y, Yoshinaka H, Owaki T, Sakamoto A, Yoshida H et al: A case of breast carcinoma with cartilaginous and osseous metaplasia. Breast Cancer. 2006;13(2):214-9.10.2325/jbcs.13.21416755121Search in Google Scholar

4. Rosen PP.: Rosen’s breast pathology. 2nd ed. Philadelphia, PA: Lippincott- Williams&Wilkins; 2001: 425-452Search in Google Scholar

5. Tavassoli FA, Devilee P.: Tumours of the breast and female genital organs. Lyon, France, IARC Press; 2003: p 37-41Search in Google Scholar

6. Tavassoli Fattaneh: Pathology of the breast. Hong- Kong, McGraw-Hill Professional, 1999: p 504Search in Google Scholar

7. An T., Grathwohl M., Frabe W.J.: Breat carcinoma with osseous metaplasia: An electron microscopic study. Am.J.Clin.Pathol., 1984, 81: 127-13210.1093/ajcp/81.1.1276318548Search in Google Scholar

8. Chhieng C, Cranor M, Lesser ME, Rosen PP.: Metaplastic carcinoma of the breast with osteocartilaginous heterologous elements. Am J Surg Pathol. 1998 Feb;22(2):188-94.10.1097/00000478-199802000-000069500219Search in Google Scholar

9. Tavassoli Fattaneh: Pathology of the breast. Hong- Kong, McGraw-Hill Professional, 1999: p 614Search in Google Scholar

10. Carter MR, Hornick JL, Lester S, Fletcher CD.: Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 2006 Mar;30(3):300-9.10.1097/01.pas.0000184809.27735.a116538049Search in Google Scholar

11. Rungta S, Kleer CG.: Metaplastic carcinomas of the breast: diagnostic challenges and new translational insights. Arch Pathol Lab Med. 2012 Aug;136(8):896-90010.5858/arpa.2012-0166-CR390664122849737Search in Google Scholar

12. Bae SY, Lee SK, Koo MY, Hur SM, Choi MY, Cho DH et al: The prognoses of metaplastic breast cancer patients compared to those of triple-negative breast cancer patients. Breast Cancer Res Treat. 2011 Apr;126(2):471-810.1007/s10549-011-1359-821287362Search in Google Scholar

13. Davis WG, Hennessy B, Babiera G, Hunt K, Valero V, Buchholz TA et al: Metaplastic sarcomatoid carcinoma of the breast with absent or minimal overt invasive carcinomatous component: a misnomer. Am J Surg Pathol. 2005 Nov;29(11):1456-63.10.1097/01.pas.0000176431.96326.4916224212Search in Google Scholar

14. Gibson G.R., Qian D., Ku J.K., et al. Metaplastic breast cancer: clinical features and outcomes, Am. Surg. 71 (2005) 725-730Search in Google Scholar

15. .Weigelt B, Kreike B, Reis-Filho JS.: Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis. Breast Cancer Res Treat. 2009 Sep;117(2):273-80. Epub 2008 Sep 25.10.1007/s10549-008-0197-918815879Search in Google Scholar

16. Gutman H, Poouck RE, Janjan NA et al: Biologic distinction and therapeutic implications of sarcomatoid metaplasia of epithelial carcinoma of the breast. J Am Coll Surg. 1995; 180: 193-199Search in Google Scholar

17. Tseng WH, Martinez SR.: Metaplastic breast cancer: to radiate or not to radiate? Ann Surg Oncol. 2011 Jan;18(1):94-10310.1245/s10434-010-1198-6301825920585866Search in Google Scholar

18. Liedtke C, Mazouni C, Hess KR, André F, Tordai A, Mejia JA et al: Response to neoadjuvant therapy and longterm survival in patients with triple-negative breast cancer. J Clin Oncol. 2008 Mar 10;26(8):1275-8110.1200/JCO.2007.14.414718250347Search in Google Scholar

19. Leibl S., Moinfar F.: Metaplastic breast carcinomas are negative for Her-2 but frequently express EGFR (Her-1): potential relevance to adjuvant treatment with EGFR tyrosine kinase inhibitors? J.Clin.Pathol., 2005; 58: 700-704Search in Google Scholar

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