<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.</p>
</abstract>

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.

EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

Department of Diagnostics and Public Health, Section of Pathology

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all...

EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

Publicado en línea: 08 may 2023

Páginas: 116 - 124

Recibido: 27 oct 2022

DOI: https://doi.org/10.2478/rjim-2023-0008

Palabras clave
endoscopic ultrasound-guided fine needle aspiration, endoscopic ultrasound-guided fine needle biopsy, immunohistochemistry, osteoclast-like giant cell, pancreatic cancer, tumor markers

© 2023 Ruxandra Mihaela Pop et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

Publicado en línea: 08 may 2023

Páginas: 116 - 124

Recibido: 27 oct 2022

DOI: https://doi.org/10.2478/rjim-2023-0008

Palabras claveendoscopic ultrasound-guided fine needle aspiration, endoscopic ultrasound-guided fine needle biopsy, immunohistochemistry, osteoclast-like giant cell, pancreatic cancer, tumor markers

© 2023 Ruxandra Mihaela Pop et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
endoscopic ultrasound-guided fine needle aspiration, endoscopic ultrasound-guided fine needle biopsy, immunohistochemistry, osteoclast-like giant cell, pancreatic cancer, tumor markers