1. bookAHEAD OF PRINT
Detalles de la revista
License
Formato
Revista
eISSN
2501-062X
Primera edición
30 Mar 2015
Calendario de la edición
4 veces al año
Idiomas
Inglés
access type Acceso abierto

Lung cancer and combined pulmonary fibrosis and emphysema with anti-ARS antibody

Publicado en línea: 22 May 2022
Volumen & Edición: AHEAD OF PRINT
Páginas: -
Recibido: 22 May 2021
Detalles de la revista
License
Formato
Revista
eISSN
2501-062X
Primera edición
30 Mar 2015
Calendario de la edición
4 veces al año
Idiomas
Inglés
Abstract

A 59-year-old man who had smoked for 23 pack-years was admitted to our hospital because of two-month history of back pain. The chest computed tomography scan demonstrated combined pulmonary fibrosis and emphysema (CPFE) and an irregular shaped nodule in the left lower lobe of the lung. A biopsy obtained from samples from subcarinal lymph nodes revealed non-small cell lung cancer. Anti-aminoacyl-tRNA synthetase (ARS) antibody was elevated up to 166 U/mL, although he had no symptoms suggestive connective tissue diseases. It is well known that most of CPFE patients are current or former heavy smokers, and some researchers described the relationship between CPFE and connective tissue diseases. To our best knowledge, this was the first report of lung cancer in patient with anti-ARS antibody-positive CPFE. In some anti-ARS antibody-positive patients, smoking might have a relationship with development of CPFE and lung cancer.

Keywords

1. BOLAKI M, ANTONIOU KM. Combined Pulmonary Fibrosis and Emphysema. Semin Respir Crit Care Med 2020; 41(2): 17-183.10.1055/s-0040-1708058 Search in Google Scholar

2. HAGE R, GAUTSCHI F, STEINACK C, SCHUURMANS MM. Combined Pulmonary Fibrosis and Emphysema (CPFE) Clinical Features and Management. Int J Chron Obstruct Pulmon Dis 2021; 16: 167-77.10.2147/COPD.S286360 Search in Google Scholar

3. KOO BS, PARK KY, LEE HJ, KIM HJ, AHN HS, YIM SY, et al. Effect of combined pulmonary fibrosis and emphysema on patients with connective tissue diseases and systemic sclerosis: a systematic review and meta-analysis. Arthritis Res Ther 2021; 23(1): 100.10.1186/s13075-021-02494-y Search in Google Scholar

4. COTTIN V, NUNES H, MOUTHON L, GAMONDES D, LAZOR R, HACHULLA E, et al. Combined pulmonary fibrosis and emphysema syndrome in connective tissue disease. Arthritis Rheum 2011; 63(1): 295-304.10.1002/art.30077 Search in Google Scholar

5. HAMAGUCHI Y, FUJIMOTO M, MATSUSHITA T, KAJI K, KOMURA K, HASEGAWA M, et al. Common and distinct clinical features in adult patients with anti-aminoacyl-t-RNA synthetase antibodies: heterogeneity within the syndrome. PLoS One 2013; 8: e60442.10.1371/journal.pone.0060442 Search in Google Scholar

6. KOREEDA Y, HIGASHIMOTO I, YAMAMOTO M, TAKAHASHI M, KAJI K, FUJIMOTO M, et al. Clinical and pathological findings of interstitial lung disease patients with anti-aminoacyl-tRNA synthetase autoantibodies. Intern Med 2010; 49(5): 361-9.10.2169/internalmedicine.49.2889 Search in Google Scholar

7. DAIDO W, YAMASAKI M, MORIO Y, FUNAISHI K, ISHIYAMA S, DEGUCHI N, et al. A rare combination of dermatomyositis, IP, and lung cancer in a patient treated with immunosuppressive therapy and chemotherapy. Intern Med. 2018; 57(6): 849-53.10.2169/internalmedicine.9642-17 Search in Google Scholar

8. TARGOFF IN. Immune manifestations of inflammatory muscle disease. Rheum Dis Clin North Am 1994; 20(4): 857-80.10.1016/S0889-857X(21)00070-3 Search in Google Scholar

9. MARGUERIE C, BUNN CC, BEYNON HL, BERNSTEIN RM, HUGHES JM, SO AK, et al. Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes. Q J Med 1990; 77(282): 1019-38.10.1093/qjmed/77.1.10192267280 Search in Google Scholar

10. LOVE LA, LEFF RL, FRASER DD, TARGOFF IN, DALAKAS M, PLOTZ PH, et al. A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore) 1991; 70(6): 360-74.10.1097/00005792-199111000-000021659647 Search in Google Scholar

11. HIRAKATA M, NAGAI S. Interstitial lung disease in polymyositis and dermatomyositis. Curr Opin Rheumatol 2000; 12(6): 501-8.10.1097/00002281-200011000-0000511092199 Search in Google Scholar

12. YOKOI E, HARUTA Y, WADA Y, ITO H, MACHIDA K, MATSUO M. Three cases of interstitial pneumonia with anti-aminoacyl tRNA synthetase antibodies complicated by gynecological cancer. Nihon Kokyuuki Gakkai Zassi 2018: 7(4): 229-32(in Japanese). Search in Google Scholar

13. SHIKANO K, KANEKO K, KABURAKI K, ISOBE K, KAWABE K, HOMMA S, et al. Nivolumab-induced anti-aminoacyl-tRNA synthetase antibody-positive polymyositis complicated by interstitial pneumonia in a patient with lung adenocarcinoma. Scand J Rheumatol 2020; 49(1): 82-83.10.1080/03009742.2019.159630931135242 Search in Google Scholar

14. FUJITA Y, HIRANO S, YONESHIM Y, IZUMI S, TAKEDA Y, SUGIYAMA H, et al. A case of acute exacerbation of interstitial pneumonia complicated with dermatomyositis during treatment for lung cancer, and literature review. Nihon Kokyuki Gakkai Zasshi 2011; 49(2): 108-15 (in Japanese). Search in Google Scholar

Artículos recomendados de Trend MD

Planifique su conferencia remota con Sciendo