1. bookVolumen 57 (2019): Edición 4 (December 2019)
Detalles de la revista
Primera edición
30 Mar 2015
Calendario de la edición
4 veces al año
Acceso abierto

The neutrophil to lymphocyte ratio in heart failure: a comprehensive review

Publicado en línea: 16 Dec 2019
Volumen & Edición: Volumen 57 (2019) - Edición 4 (December 2019)
Páginas: 296 - 314
Recibido: 01 Jun 2019
Detalles de la revista
Primera edición
30 Mar 2015
Calendario de la edición
4 veces al año

1. SHIRAZI, L.F., BISSETT, J., ROMEO, F., MEHTA, J.L. Role of inflammation in heart failure. Current Atherosclerosis Reports. 2017; 19(6):27.10.1007/s11883-017-0660-3Search in Google Scholar

2. VAN LINTHOUT, S., TSCHÖPE, C. Inflammation – cause or consequence of heart failure or both?. Curr. Heart Fail. Rep. 2017; 14(4):251–265.Search in Google Scholar

3. SETA, Y., SHAN, K., BOZKURT, B., ORAL, H., MANN, D.L. Basic mechanisms in heart failure: the cytokine hypothesis. J. Card. Fail. 1996; 2(3):243–9.10.1016/S1071-9164(96)80047-9Search in Google Scholar

4. JAHNG, J.W.S., SONG, E., SWEENEY, G. Crosstalk between the heart and peripheral organs in heart failure. Exp. Mol. Med. 2016; 48(3):e217.10.1038/emm.2016.20489288126964833Search in Google Scholar

5. HARTUPEE, J., MANN, D.L. Positioning of inflammatory biomarkers in the heart failure landscape. J. Cardiovasc. Transl. Res. 2013; 6(4):485–92.Search in Google Scholar

6. TRACCHI, I., GHIGLIOTTI, G., MURA, M., GARIBALDI, S., SPALLAROSSA, P., BARISIONE, C., et al. Increased neutrophil lifespan in patients with congestive heart failure. Eur. J. Heart Fail. 2009; 11(4):378–385.10.1093/eurjhf/hfp03119276127Search in Google Scholar

7. RUDOLPH, V., RUDOLPH, T.K., HENNINGS, J.C., BLANKENBERG, S., SCHNABEL, R., STEVEN, D., et al. Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function. Free Radic. Biol. Med. 2007; 43(8):1189–1196.Search in Google Scholar

8. ARRUDA-OLSON, A.M., REEDER, G.S., BELL, M.R., WESTON, S.A., ROGER, V.L. Neutrophilia predicts death and heart failure after myocardial infarction: A community based study. Circ Cardiovasc Qual Outcomes 2009; 2(6):656–662.10.1161/CIRCOUTCOMES.108.831024285027520031905Search in Google Scholar

9. SHAH, A.D., DENAXAS, S., NICHOLAS, O., HINGORANI, A.D., HEMINGWAY, H. Neutrophil counts and initial presentation of 12 cardiovascular diseases. JACC 2017; 69(9):1160–9.10.1016/j.jacc.2016.12.022533259128254179Search in Google Scholar

10. MAISEL, A.S., KNOWLTON, K.U., FOWLER, P., REARDEN, A., ZIEGLER, M.G., MOTULSKY, H.J., et al. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J. Clin. Invest. 1990; 85(2):462–7.10.1172/JCI1144602964462153706Search in Google Scholar

11. VADUGANATHAN, M., GREENE, S.J., BUTLER, J., SABBAH, H.N., SHANTSILA, E., LIP, G.Y.H., et al. The immunological axis in heart failure: Importance of the leukocyte differential. Heart Fail. Rev. 2013; 18(6):835–845.Search in Google Scholar

12. YUCEL, H., EGE, M.R., ZORLU, A., KAYA, H., BETON, O., GUNGOR, H., et al. Lymphocytopenia is associated with poor NYHA functional class in chronic heart failure patients with reduced ejection fraction. Turk Kardiyol. Dern. Arsivi-Archives Turkish Soc. Cardiol. 2015; 43(5):427–433.Search in Google Scholar

13. CHARACH, G., GROSSKOPF, I., ROTH, A., AFEK, A., WEXLER, D., SHEPS, D., et al. Usefulness of total lymphocyte count as predictor of outcome in patients with chronic heart failure. Am. J. Cardiol. 2011; 107(9):1353–1356.10.1016/j.amjcard.2010.12.04921371686Search in Google Scholar

14. VADUGANATHAN, M., AMBROSY, A.P., GREENE, S.J., MENTZ, R.J., SUBACIUS, H.P., MAGGIONI, A.P., et al. Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction. Circ. Hear. Fail. 2012; 5(6):750–758.10.1161/CIRCHEARTFAILURE.112.97052523051949Search in Google Scholar

15. BHAT, T., TELI, S., RIJAL, J., BHAT, H., RAZA, M., KHOUEIRY, G., et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev. Cardiovasc. Ther. 2013; 11(1):55–9.Search in Google Scholar

16. ZHANG, S., DIAO, J., QI, C., JIN, J., LI, L., GAO, X., et al. Predictive value of neutrophil to lymphocyte ratio in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention: a meta-analysis. BMC Cardiovasc. Disord. 2018; 18(1):75.Search in Google Scholar

17. PAQUISSI, F.C. The predictive role of inflammatory biomarkers in atrial fibrillation as seen through neutrophil-lymphocyte ratio mirror. J. Biomarkers 2016; 2016:1–14.10.1155/2016/8160393494750027446629Search in Google Scholar

18. AFARI, M.E., BHAT, T. Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update. Expert Rev. Cardiovasc. Ther. 2016; 14(5):573–577.Search in Google Scholar

19. UTHAMALINGAM, S., PATVARDHAN, E. A, SUBRAMANIAN, S., AHMED, W., MARTIN, W., DALEY, M., et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am. J. Cardiol. 2011; 107(3):433–438.10.1016/j.amjcard.2010.09.039Search in Google Scholar

20. BENITES-ZAPATA, V. A., HERNANDEZ, A. V., NAGARAJAN, V., CAUTHEN, C. A., STARLING, R.C., WILSON TANG, W.H. Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure. Am. J. Cardiol. 2015; 115(1):57–61.10.1016/j.amjcard.2014.10.008Search in Google Scholar

21. WASILEWSKI, J., PYKA, Ł., HAWRANEK, M., OSADNIK, T., KUREK, A., SKRZYPEK, M., et al. Prognostic value of neutrophil-to-lymphocyte ratio in predicting long-term mortality in patients with ischemic and nonischemic heart failure. Pol. Arch. Med. Wewn. 2016; 126(3):166–173.Search in Google Scholar

22. WAN, G., JI, L., XIA, W., CHENG, L., ZHANG, Y. Screening genes associated with elevated neutrophil-to-lymphocyte ratio in chronic heart failure. Mol. Med. Rep. 2018; 18(2):1415–1422.Search in Google Scholar

23. CAKICI, M., CETIN, M., DOGAN, A., OYLUMLU, M., POLAT, M., SUNER, A. Neutrophil to lymphocyte ratio predicts poor functional capacity in patients with heart failure. Arch Turk Soc Cardiol 2014; 42(7):612–620.10.5543/tkda.2014.16363Search in Google Scholar

24. TURFAN, M., ERDOGAN, E., TASAL, A., VATANKULU, M., JAFAROV, P., SONMEZ, O., et al. Neutrophil-to-lymphocyte ratio and in-hospital mortality in patients with acute heart failure. Clinics 2014; 69(3):190–193.10.6061/clinics/2014(03)08Search in Google Scholar

25. OSTROWSKA, M., OSTROWSKI, A., ŁUCZAK, M., JAGUSZEWSKI, M., ADAMSKI, P., BELLWON, J., et al. Basic laboratory parameters as predictors of in-hospital death in patients with acute decompensated heart failure: data from a large single-centre cohort. Kardiol. Pol. 2016; 75(2):157–163.Search in Google Scholar

26. LIU, S., WANG, P., SHEN, P.-P., ZHOU, J.-H. Predictive values of red blood cell distribution width in assessing severity of chronic heart failure. Med. Sci. Monit. 2016; 22:2119–2125.Search in Google Scholar

27. TASAL, A., ERTURK, M., UYAREL, H., KARAKURT, H., BACAKSIZ, A., VATANKULU, M.A., et al. Utility of the neutrophil to lymphocyte ratio for predicting in-hospital mortality after levosimendan infusion in patients with acute decompensated heart failure. J. Cardiol. 2014; 63(6):418–423.Search in Google Scholar

28. DURMUS, E., KIVRAK, T., GERIN, F., SUNBUL, M., SARI, I., ERDOGAN, O. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are predictors of heart failure. Arq. Bras. Cardiol. 2015; (June 2012):606–613.10.5935/abc.20150126469366526536980Search in Google Scholar

29. FU, S., XIE, L., LI, D., YE, P., LUO, L. The predictive capacity and additional prognostic power of N-terminal pro-B-type natriuretic peptide in Chinese elderly with chronic heart failure. Clin. Interv. Aging 2015; 10:359–365.Search in Google Scholar

30. HUANG, W.M., CHENG, H.M., HUANG, C.J., GUO, C.Y., LU, D.Y., LEE, C.W., et al. Hemographic indices are associated with mortality in acute heart failure /692/4019/592/75/74 /692/4019/592/75/230 article. Sci. Rep. 2017; 7(1):1–9.Search in Google Scholar

31. AVCI, A., ALIZADE, E., FIDAN, S., YESIN, M., GULER, Y. Neutrophil/lymphocyte ratio is related to the severity of idiopathic dilated cardiomyopathy. Scand Cardiovasc J 2014; 48(4):202–8.10.3109/14017431.2014.93292224912526Search in Google Scholar

32. YILDIZ, A., YÜKSEL, M., OYLUMLU, M., POLAT, N., AKIL, M.A., ACET, H. The association between the neutrophil/lymphocyte ratio and functional capacity in patients with idiopathic dilated cardiomyopathy. Anadolu Kardiyol. Derg. 2015; 15(1):13–17.Search in Google Scholar

33. SOBRINO-MÁRQUEZ, J.M., GRANDE-TRILLO, A., CANTERO-PÉREZ, E.M., RANGEL-SOUSA, D., LAGE-GALLE, E., ADSUAR-GÓMEZ, A. Prognostic value of blood panel parameters in patients with dilated cardiomyopathy and advanced heart failure. Transplant. Proc. 2018; 50(2):650–652.Search in Google Scholar

34. YAN, W., LIU, C., LI, R., MU, Y., JIA, Q., HE, K. Usefulness of the neutrophil-to-lymphocyte ratio in predicting adverse events in elderly patients with chronic heart failure. Int. Heart J. 2016; 57(5):615–621.Search in Google Scholar

35. YAN, W., LI, R.J., JIA, Q., MU, Y., LIU, C.L., HE, K.L. Neutrophil-to-lymphocyte ratio compared to N-terminal pro-brain natriuretic peptide as a prognostic marker of adverse events in elderly patients with chronic heart failure. J. Geriatr. Cardiol. 2017; 14(2):127–134.Search in Google Scholar

36. SAROJINI, A., SAI RAVI SHANKER, A., ANITHA, M. Inflammatory markers-serum level of c-reactive protein, tumor necrotic factor-α, and interleukin-6 as predictors of outcome for peripartum cardiomyopathy. J. Obstet. Gynecol. India 2013; 63(4):234–239.Search in Google Scholar

37. AZIBANI, F., SLIWA, K. Peripartum cardiomyopathy: an update. Curr. Heart Fail. Rep. 2018; 15(5):297–306.Search in Google Scholar

38. GÜRKAN, U., AKGÖZ, H., AKSOY, Ş., CAN GÜRKAN, Ö., OSKEN, A., UNAL DAYI, S., et al. Value of the neutrophil-tolymphocyte ratio in predicting left ventricular recovery in patients with peripartum cardiomyopathy. Wien. Klin. Wochenschr. 2017; 129(23–24):893–899.10.1007/s00508-017-1227-628702739Search in Google Scholar

39. URAL, D. Neutrophil-to-lymphocyte ratio predicts response to cardiac resynchronization therapy. Med. Sci. Monit. 2013; 19:373–377.Search in Google Scholar

40. BALCI, K.G., BALCI, M.M., SEN, F., CANPOLAT, U., AKBOGA, M.K., UNAL, S., et al. The role of baseline indirect inflammatory markers in prediction of response to cardiac resynchronisation therapy. Kardiol. Pol. 2016; 74(2):119–126.Search in Google Scholar

41. BOROS, A.M., SZÉPLAKI, G., PERGE, P., JENEI, Z., BAGYURA, Z., ZIMA, E., et al. The ratio of the neutrophil leucocytes to the lymphocytes predicts the outcome after cardiac resynchronization therapy. Europace 2016; 18(5):747–754.10.1093/europace/euv100488011025972301Search in Google Scholar

42. HASHIMOTO, N., ARIMOTO, T., NARUMI, T., IWAYAMA, T., KUTSUZAWA, D., ISHIGAKI, D., et al. The neutrophil-tolymphocyte ratio predicts all-cause mortality in patients with implantable cardioverter defibrillators. PACE – Pacing Clin. Electrophysiol. 2017; 40(2):135–144.10.1111/pace.1300327996101Search in Google Scholar

43. UCAR, F., ACAR, B. Neutrophil to lymphocyte ratio predicts appropriate therapy in idiopathic dilated cardiomyopathy patients with primary prevention implantable cardioverter defibrillator. Saudi Med J 2017; 38(2):143–148.10.15537/smj.2017.2.15929532962528133686Search in Google Scholar

44. YOST, G., JOSEPH, C., TATOOLES, A., BHAT, G. Neutrophil-to-lymphocyte ratio predicts outcomes in patients implanted with left ventricular assist devices. ASAIO J. 2015; 61:664–9.10.1097/MAT.000000000000026726181711Search in Google Scholar

45. BHAT, G., YOST, G.L., IBRAHIM, K., PAPPAS, P., TATOOLES, A. Risk stratification with longitudinal neutrophil to lymphocyte ratio assessment after left ventricular assist device implantation. Int. J. Artif. Organs 2018; 41(8):445–451.Search in Google Scholar

46. FERRERA, C., GONZALEZ FERNANDEZ, O., BOUZAS, N., CASTRODEZA, J., GREEN, T., WOODS, A., et al. Neutrophil to lymphocyte ratio is related to thrombotic complications and survival in continuous flow left ventricular assist devices. ASAIO J. 2019; [Epub ahead of print]10.1097/MAT.000000000000097130913104Search in Google Scholar

47. SUNDARARAJAN, S., KIERNAN, M.S., COUPER, G.S., UPSHAW, J.N., DENOFRIO, D., VEST, A.R. The neutrophillymphocyte ratio and survival during left ventricular assist device support. J. Card. Fail. 2019; 25(3):188–194.10.1016/j.cardfail.2019.01.00530658084Search in Google Scholar

48. KARACAGLAR, E., BAL, U., CIFTCI, O., TURGAY, O., YILMAZ, M., SADE, E., et al. Predictive value of hematologic parameters for detecting asymptomatic graft rejection after heart transplant: Preliminary results. Exp. Clin. Transplant. 2015; 13:146–148.Search in Google Scholar

49. CHOI, D.-H., KOBAYASHI, Y., NISHI, T., LUIKART, H., DIMBIL, S., KOBASHIGAWA, J., et al. Change in lymphocyte to neutrophil ratio predicts acute rejection after heart transplantation. Int. J. Cardiol. 2018; 251:58–64.Search in Google Scholar

50. SEROPIAN, I.M., ROMEO, F.J., PIZARRO, R., VULCANO, N.O., POSATINI, R.A., MARENCHINO, R.G., et al. Neutrophilto-lymphocyte ratio and platelet-to-lymphocyte ratio as predictors of survival after heart transplantation. ESC Hear. Fail. 2018; 5(1):149–156.Search in Google Scholar

51. ARGAN, O., URAL, D., KOZDAG, G., SAHIN, T., BOZYEL, S., AKTAS, M., et al. Associations between neutrophil gelatinase associated lipocalin, neutrophil-to-lymphocyte ratio, atrial fibrillation and renal dysfunction in chronic heart failure 2016; 4765–4772.10.12659/MSM.898608Search in Google Scholar

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