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Ketamine-based versus fentanyl-based regimen for rapid-sequence endotracheal intubation in patients with septic shock: A randomised controlled trial

Hassan Ali
Hassan Ali
, 
Bassant Mohamed Abdelhamid
Bassant Mohamed Abdelhamid
, 
Ahmed M Hasanin
Ahmed M Hasanin
, 
Aya Abou Amer
Aya Abou Amer
 y 
Ashraf Rady
Ashraf Rady
   | 29 dic 2022
Romanian Journal of Anaesthesia and Intensive Care's Cover Image
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Article Category: Original Paper
Publicado en línea: 29 dic 2022
Páginas: 98 - 104
DOI: https://doi.org/10.2478/rjaic-2021-0017
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© 2021 Ali et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

CONSORT’s flow chart.
CONSORT’s flow chart.

Figure 2

Mean arterial pressure. Markers are means and error bars are standard deviations. * denotes statistical significance between both groups, † denotes statistical significance compared to the baseline reading within fentanyl group.
Mean arterial pressure. Markers are means and error bars are standard deviations. * denotes statistical significance between both groups, † denotes statistical significance compared to the baseline reading within fentanyl group.

Figure 3

Heart rate. Markers are means and error bars are standard deviations. † denotes statistical significance compared to the baseline reading within fentanyl group.
Heart rate. Markers are means and error bars are standard deviations. † denotes statistical significance compared to the baseline reading within fentanyl group.

Figure 4

Cardiac output. Markers are means and error bars are standard deviations. † denotes statistical significance compared to the baseline reading within fentanyl group.
Cardiac output. Markers are means and error bars are standard deviations. † denotes statistical significance compared to the baseline reading within fentanyl group.

Demographic data and baseline characteristics. Data are presented as mean (standard deviation), median (quartiles), and frequency (%).

  Ketamine group (n=23) Fentanyl group (n=19) P-value
Age (years) 44 (40-60) 56 (46-63) 0.356
Male gender (%) 11 (47.8%) 8 (42.1%) 0.763
Source of sepsis      
• Abdominal 17 (73.9%) 18 (94.7%) 0.071
• Other 6 (26.1%) 1 (5.3%)  
Mean arterial pressure (mmHg) 74 (13) 67 (9) 0.113
Heart rate (bpm) 111 (21) 109 (24) 0.837
Shock index 1.1 (0.3) 1.2 (0.3) 0.563
Stroke volume (ml) 63 (30) 78 (28) 0.114
Cardiac output (L/min) 7.1 (3.4) 8.5 (3.5) 0.209
Systemic vascular resistance (dynes/seconds/cm5) 821 (325) 715 (389) 0.350
Haemoglobin (g/dL) 10.7 (9.5, 11.7) 10.8 (8.8, 11.5) 0.411
Prothrombin concentration (%) 59 (18) 58 (12) 0.773
Urea (mg/dL) 51 (27, 113) 49 (29, 98) 0.889
Creatinine (mg/dL) 1.4 (1.0, 2.1) 1.4 (1.2, 3.1) 0.447

Intraoperative outcomes. Data are presented as mean (standard deviation), median (quartiles), and frequency (%).

  Ketamine group (n=15) Fentanyl group (n=16) P-value
Mean blood pressure at 1 min (mmHg) 77 (13) 63 (6) 0.001
Patients with post-induction hypotension 11 (47.8%)* 16 (84.2%) 0.014
Serum lactate (baseline) (mmol/dL) 3.2 (2.3, 4.1) 2.8 (2.2, 4.3) 0.544
Serum (mmol/lactate dL) (after 15 minutes) 2.2 (1.8, 3.4)† 2.6 (2.2, 3.6)† 0.471
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Calendario de la edición:
2 veces al año
Temas de la revista:
Medicine, Clinical Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine
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