<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background and aims</h3>
<p>The pain of labour is very severe. Most women prefer painless labour to routine labour if they are aware of the methods of analgesia. The aim of this study was to evaluate the effect of dexmedetomidine intravenous infusion on labour pain management in primipara term pregnant women.</p>
</sec>
<sec><h3>Methods</h3>
<p>In this nonrandomised clinical trial with control group, all primipara term pregnant women from August 2019 to March 2020 were included. In the intervention group, after the active phase of labour, dexmedetomidine was given according to the protocol and continued until phase 2 of labour. The control group received no intervention to reduce pain. Patients in both groups were evaluated for fetal heart rate, Apgar scores, vital signs, pain intensity, and sedation score.</p>
</sec>
<sec><h3>Results</h3>
<p>There were no significant differences in primary fetal heart rate, primary maternal hemodynamics, and mean Apgar scores at 1 and 5 minutes between the two groups (p > .05). There was no significant difference in the mean fetal heart rate in different stages between the two groups. Intragroup analysis in the intervention group showed that mean systolic and diastolic blood pressures were significantly decreased after drug administration but were in the normal range. The active phase of labour in the intervention group was significantly shorter than in the control group (p = 0.002). The mean Visual Analogue Scale (VAS) score after dexmedetomidine administration decreased significantly from 9.25 at baseline to 4.61 after drug administration, 3.88 during labour, and 1.88 after placental expulsion. The mean Ramsay Sedation Scale score after dexmedetomidine administration increased significantly from 1.00 at baseline to 2.05 after drug administration, 2.22 during labour, and 2.05 after placental expulsion.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Based on the study's results, the administration of dexmedetomidine to manage labour pain with careful monitoring of mother and fetus is recommended.</p>
</sec>
</abstract>

Background and aims
The pain of labour is very severe. Most women prefer painless labour to routine labour if they are aware of the methods of analgesia. The aim of this study was to evaluate the effect of dexmedetomidine intravenous infusion on labour pain management in primipara term pregnant women.

Methods
In this nonrandomised clinical trial with control group, all primipara term pregnant women from August 2019 to March 2020 were included. In the intervention group, after the active phase of labour, dexmedetomidine was given according to the protocol and continued until phase 2 of labour. The control group received no intervention to reduce pain. Patients in both groups were evaluated for fetal heart rate, Apgar scores, vital signs, pain intensity, and sedation score.

Results
There were no significant differences in primary fetal heart rate, primary maternal hemodynamics, and mean Apgar scores at 1 and 5 minutes between the two groups (p > .05). There was no significant difference in the mean fetal heart rate in different stages between the two groups. Intragroup analysis in the intervention group showed that mean systolic and diastolic blood pressures were significantly decreased after drug administration but were in the normal range. The active phase of labour in the intervention group was significantly shorter than in the control group (p = 0.002). The mean Visual Analogue Scale (VAS) score after dexmedetomidine administration decreased significantly from 9.25 at baseline to 4.61 after drug administration, 3.88 during labour, and 1.88 after placental expulsion. The mean Ramsay Sedation Scale score after dexmedetomidine administration increased significantly from 1.00 at baseline to 2.05 after drug administration, 2.22 during labour, and 2.05 after placental expulsion.

Conclusion
Based on the study's results, the administration of dexmedetomidine to manage labour pain with careful monitoring of mother and fetus is recommended.

Evaluating the Effect of Dexmedetomidine Intravenous Infusion on Labour Pain Management in Primipara Pregnant Women: A Nonrandomised Clinical Trial Study

Baqiyatallah University of Medical Sciences

Romanian Journal of Anaesthesia and Intensive Care

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background and aims
The pain of labour is very severe. Most women prefer painless labour to routine labour if they are aware of the methods of analgesia. The...

	groups	N	Minimum	Maximum	Mean	Std. Deviation	p-value
Age (year)	intervention	20	22	38	27.9000	4.51	0.79
Age (year)	control	26	18	36	26.5385	4.76	0.79

Height (cm)	intervention	20	157	170	162.7500	4.35	0.94
Height (cm)	control	26	147	173	162.6154	7.40	0.94

Weight (kg)	intervention	20	59	88	77.0000	13.79	0.2
Weight (kg)	control	26	51	98	72.1154	11.77	0.2

Dilatation (cm)	intervention	20	4	8	5.42	5.42	0.89
Dilatation (cm)	control	26	4	7	5.38	5.38	0.89

Effacement (%)	intervention	20	30	90	53.15	53.15	0.87
Effacement (%)	control	26	30	80	53.84	53.84	0.87

	groups	N	Minimum	Maximum	Mean	Std. Deviation	p-value
Stage I	intervention	17	10	300	81.23	75.83	0.002
Stage I	control	24	33	402	192.75	120.76

Stage II	intervention	17	10	90	42.47	27.58	0.95
Stage II	control	24	10	93	41.95	23.87

Stage III	intervention	17	4	10	5.94	1.71	0.47
Stage III	control	24	4	50	7.58	9.16

Evaluating the Effect of Dexmedetomidine Intravenous Infusion on Labour Pain Management in Primipara Pregnant Women: A Nonrandomised Clinical Trial Study

Article Category: Original Article

Publicado en línea: 25 sept 2022

Páginas: 10 - 18

DOI: https://doi.org/10.2478/rjaic-2021-0002

Palabras clave
dexmedetomidine, intravenous analgesia, painless labour

© 2021 Abasali Delavari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Figure 2

Figure 3

Comparison of demographic characteristics between the two groups

Comparing mean duration of labor stages (minutes) between the two groups

Evaluating the Effect of Dexmedetomidine Intravenous Infusion on Labour Pain Management in Primipara Pregnant Women: A Nonrandomised Clinical Trial Study

Article Category: Original Article

Publicado en línea: 25 sept 2022

Páginas: 10 - 18

DOI: https://doi.org/10.2478/rjaic-2021-0002

Palabras clavedexmedetomidine, intravenous analgesia, painless labour

© 2021 Abasali Delavari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Figure 2

Figure 3

Comparison of demographic characteristics between the two groups

Comparing mean duration of labor stages (minutes) between the two groups

Palabras clave
dexmedetomidine, intravenous analgesia, painless labour