Does volume change of the spleen correlate with the therapy response in uveal melanoma patients with liver metastases undergoing hepatic artery infusion chemotherapy?
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05 sept 2025
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Categoría del artículo: Research Article
Publicado en línea: 05 sept 2025
Páginas: 383 - 390
Recibido: 03 mar 2025
Aceptado: 22 may 2025
DOI: https://doi.org/10.2478/raon-2025-0047
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© 2025 Hannah Luisa Steinberg-Vorhoff et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
FIGURE 1.
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FIGURE 5.
FIGURE 6.
Median overall survival and accordance of treatment response evaluation by RECIST 1_1 and spleen volumetry with a threshold of 5% increase in spleen volume
| Spleen volumetry | |||
|---|---|---|---|
| RECIST 1.1 criteria | Stable (spleen volume decrease or increase up to max. 5%) | Increase (spleen volume increases more than 5%) | Total |
| SD + PR | 15.8 months (n = 85) | 13.8 months (n = 64) | 15.1 months (n = 149) |
| PD | 9.5 months (n = 12) | 8.5 months (n = 18) | 8.3 months (n = 30) |
| Total | 15.1 months (n = 97) | 11.5 months (n = 82) | 13.8 months (n = 179) |
Patient characteristics
| All patients (n = 179) | Splenomegaly (n = 25) | No Splenomegaly (n = 154) | p-value | |
|---|---|---|---|---|
| Age (mean/SD) | 64.8 years, 11.0 years | 61.9 years, 12.5 years | 65.0 years, 10.7 years | 0.2 |
| Gender (female/male) | 95 (53 %) / 84 (47 %) | 4 (16 %) / 21 (84 %) | 91 (59 %) / 63 (41 %) | |
| Number of HAIC per patient | 5 (3–10) | 5 (3–11) | 5 (3–9) | 0.8 |
| Spleen | ||||
| Volume before first HAIC | 205 ml (150–263 ml) | 362 ml (347–407 ml) | 186 ml (142–237 ml) | < 0.0001 |
| Volume after first HAIC | 213 ml (155–279 ml) | 385 ml (345–430 ml) | 200 ml (151–241 ml) | < 0.0001 |
| Volume change | +4.0 % (-4.0 – +12.0%) | + 6.5 % (-5.8 – +11.5%) | +3.6 % (-3.4 – +12.2%) | 0.8 |
| Liver | ||||
| Volume before first HAIC | 1731 ml (1426–2228 ml) | 2358 ml (1936–2787 ml) | 1637 ml (1405–2050 ml) | < 0.0001 |
| Volume after first HAIC | 1780 ml (1447–2406 ml) | 2354 (1983–2894 ml) | 1741 ml (1431–2240 ml) | 0.0009 |
| Volume change | +4.0 % (-2.0 – +13.0%) | -0.5 % (-9.4 – +6.9%) | +5.0 % (-1.7 – +13.4%) | 0.04 |
| RECIST 1.1 liver index size change | +2.8 % (-6.5 – +14.3%) | +2.5 % (-3.0 – +10.2%) | +3.3 % (-7.2 – +16.1%) | 0.7 |
| Overall survival | 13.7 months (7.3–21.2 months) | 10.7 months (5.2–19.2 months) | 13.8 months (7.3–21.8 months) | 0.6 |