Bronchial bacterial colonization and the susceptibility of isolated bacteria in patients with lung malignancy

Susceptibility among patients colonized by potentially pathogenic microorganisms (PPMs)

Amoxicillin with clavulanic acid	First generation cephalosporin			Total
	R	S	S/R
R	1	1	0	2
S	1	20	0	21
S/R	0	5	3	8
Total	2	26	3	31

Susceptibility among all colonized patients

Amoxicillin with clavulanic acid	First generation cephalosporin			Total
	R	S	S/R
R	2	2	0	4
S	2	101	1	104
S/R	0	6	6	12
Total	4	109	7	120

Number and percentage of recovered bacteria

RECOVERED BACTERIA	No. of patients with isolated species	% of patients with isolated species
Streptococcus mitis	53	35,6%
Streptococcus salivarius	36	24,2%
Streptococcus oralis	27	18,1%
Streptococcus parasanguinis	23	15,4%
Streptococcus vestibularis	18	12,1%
Veillonella atypica	13	8,7%
Haemophilus influenzae	12	8,1%
Streptococcus pneumoniae	11	7,4%
Neisseria subflava	9	6,0%
Actinomyces odontolyticus	9	6,0%
Staphylococcus aureus	8	5,4%
Haemophilus parahaemolyticus	8	5,4%
Streptococcus gordonii	8	5,4%
Rothia mucilaginosa	7	4,7%
Escherichia coli	6	4,0%
Staphylococcus epidermidis	6	4,0%
Staphylococcus hominis	4	2,7%
Streptococcus anginosus	4	2,7%
Veillonella parvula	3	2,0%
Fusobacterium periodonticum	3	2,0%
Moraxella catarrhalis	2	1,3%
Pseudomonas aeruginosa	2	1,3%
Haemophilus parainfluenzae	2	1,3%
Corynebacterium simulans	2	1,3%
Prevotella nigrescens	2	1,3%
Streptococcus constellatus	2	1,3%
Gemella haemolysans	2	1,3%
Serratia marcescens	2	1,3%
Prevotella melaninogenica	2	1,3%
Granulicatella adiacens	2	1,3%
Streptococcus agalactiae	1	0,7%
Staphylococcus capitis	1	0,7%
Streptococcus cristatus	1	0,7%
Neisseria macacae	1	0,7%
Neisseria cinerea	1	0,7%
Neisseria flavescens	1	0,7%
Veillonella dispar	1	0,7%
Prevotella jejuni	1	0,7%
Campylobacter concisus	1	0,7%
Citrobacter koseri	1	0,7%
Prevotella pallens	1	0,7%
Enterobacter bugandensis	1	0,7%
Acinetobacter lwoffii	1	0,7%
Moraxella nonliquefaciens	1	0,7%

Relationship between colonization with potentially pathogeni microorganisms (PPMs) and chronic obstructive pulmonary disease (COPD)

COPD	PPMs		Total
	no	yes
no	83	21	104
	79.8%	20.2%	100.0%
yes	32	12	44
	72.7%	27.3%	100.0%
Total	115	33	148*
	77.7%	22.3%	100.0%

Baseline characteristics of patients

Characteristics	n	%
Patients	149
Male	90	60.4
Median age (years)	66
Smokers	50	33.6
Ex-smokers	71	47,7
Non-smokers	28	18,8
COPD	44	29.5
Diabetes type 2	13	8.7
Colonized patients	132	88.6
Colonized with PPMs	32	21.5
Multiple bacteria colonization	86	57.7
Adenocarcinoma	86	57.7
Squamous cell carcinoma	22	14.8
Small cell carcinoma, carcinoid or large cell carcinoma	11	7.4
Non-small cell carcinoma NOS*	17	11.4
Other, non-lung cancer malignancies (limfoma, methastases)	13	8,7

Relationship between colonization with potentially pathogenic microorganisms (PPMs) and diabetes type 2

DIABETES TYPE 2	PPMs		Total
	no	yes
no	108	27	135
	80.0%	20.0%	100.0%
yes	7	6	13
	53.8%	46.2%	100.0%
Total	115	33	148*
	77.7%	22.3%	100.0%

Relationship between cancer stage and colonization with potentially pathogenic microorganisms (PPMs)

STAGE (8th TNM classification)	PPMs		Total
	no	yes
I	50	11	61
	82.0%	18.0%	100.0%
II	25	7	32
	78.1%	21.9%	100.0%
III	16	6	22
	72.7%	27.3%	100.0%
IV	11	2	13
	84.6%	15.4%	100.0%
Total	102	26	128*
	79.7%	20.3%	100.0%