Predictive value of pretreatment peripheral blood N/CD4 and N/CD8 ratios for the efficacy of radiotherapy for esophageal cancer
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19 mar 2025
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Categoría del artículo: research article
Publicado en línea: 19 mar 2025
Páginas: 257 - 266
Recibido: 28 ago 2024
Aceptado: 06 dic 2024
DOI: https://doi.org/10.2478/raon-2025-0015
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© 2025 Yu-Rong Jiang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Figure 1.
Figure 2A
Figure 2B
Univariate Cox regression analysis of the relationship between pathophysiological parameters and survival time of patients
| Parameter | 95% CI | |
|---|---|---|
| Sex | 0.5551–0.7782 | 0.863 |
| Age | 0.7621–0.9324 | 0.424 |
| Smoking history | 0.1238–0.3206 | 0.150 |
| Drinking history | 0.1356–0.3366 | 0.073 |
| Differentiation | 1.8861–2.1416 | 0.876 |
| Tumor site | 1.9172–2.2495 | 0.977 |
| Histology | 0.9993–1.1951 | 0.150 |
| T-staging | 1.4667–1.7000 | 0.484 |
| N-staging | 0.4812–0.7133 | 0.644 |
| ECOG score | 0.3196–0.6248 | 0.000 |
| Lymphocytes | 1.1019–1.3953 | 0.690 |
| Neutrophils | 4.5463–6.0399 | 0.101 |
| CD4 | 494.9039–630.8183 | 0.003 |
| CD8 | 318.8047–410.5008 | 0.099 |
| B | 127.2621–174.9045 | 0.441 |
| NK | 311.61–429.0567 | 0.345 |
| CD4/CD8 | 1.5587–1.9595 | 0.380 |
| NLR | 4.11727–5.9177 | 0.219 |
| N/CD4 | 0.00989131–0.01451622 | 0.000 |
| N/CD8 | 0.01492113–0.02114241 | 0.000 |
| N/B | 0.04171439–0.07256377 | 0.020 |
| N/NK | 0.01579055–0.02567177 | 0.141 |
Association of pathological features and neutrophil-to-CD4+ T-cell ratio (N/CD4) in patients
| Characteristic, n = 72 | N/CD4 ≤ 0.01053329 | N/CD4 > 0.01053329 | |
|---|---|---|---|
| Sex | |||
| Female | 12 | 12 | |
| Male | 28 | 20 | 0.502 |
| Age | |||
| ≥ 64 years old | 33 | 28 | |
| < 64 years old | 7 | 4 | 0.558 |
| History of smoking | |||
| Yes | 8 | 8 | |
| No | 24 | 32 | 0.612 |
| Drinking history | |||
| Yes | 10 | 7 | |
| No | 30 | 25 | 0.756 |
| Differentiation | |||
| Highly differentiation | 6 | 5 | |
| Medium differentiation | 29 | 22 | |
| Low differentiation | 5 | 5 | 0.228 |
| Tumor site | |||
| Upper thoracic portion | 9 | 6 | |
| Middle thoracic portion | 23 | 13 | |
| Low thoracic portion | 8 | 13 | 0.032 |
| Histology | |||
| Squamous | 36 | 32 | |
| Nonsquamous | 1 | 0 | |
| Small cell | 3 | 0 | 0.368 |
| T-staging | |||
| T1 + T2 | 15 | 15 | |
| T3 + T4 | 25 | 17 | 0.423 |
| N-staging | |||
| N0 | 19 | 10 | |
| N1 + N2 | 21 | 22 | 0.162 |
| Nutriture | |||
| Benign | 19 | 13 | |
| Unbenign | 21 | 19 | 0.56 |
| Anemic state | |||
| Not anemic | 7 | 15 | |
| Anemia | 33 | 17 | 0.007 |
| Coagulation state | |||
| Normal | 30 | 23 | |
| Abnormal | 10 | 9 | 0.765 |
| ECOG score | |||
| 0 point | 24 | 20 | |
| 1 point | 11 | 11 | |
| 2 point | 5 | 1 | 0.366 |
| Treatment efficacy | |||
| CR + PR | 26 | 21 | |
| SD + PD | 14 | 11 | 0.956 |
Multivariate Cox regression analysis of the relationship between clinical variables and patient survival
| Parameter | HR | 95% CI Lower | 95% CI Upper | |
|---|---|---|---|---|
| N/CD4 | 4.14E+73 | 3.39128E+18 | 5.07E+128 | 0.009 |
| ECOG | 2.151826047 | 1.202835884 | 3.849532092 | 0.010 |
| N/CD8 | 4.27E-41 | 2.01E-75 | 9.04E-07 | 0.021 |
| N/B | 0.00138624 | 6.32E-12 | 303904.1296 | 0.502 |
| CD4 | 0.999658052 | 0.997587163 | 1.00173324 | 0.747 |
Association of pathological features and neutrophil-to-CD8+ T-cell ratio (N/CD8) in patients
| Characteristic, n = 72 | N/CD8 ≤ 0.01184294 | N/CD8 > 0.01184294 | |
|---|---|---|---|
| Sex | |||
| Female | 9 | 15 | |
| Male | 20 | 28 | 0.734 |
| Age | |||
| ≥ 64 years old | 26 | 35 | |
| < 64 years old | 3 | 8 | 0.339 |
| History of smoking | |||
| Yes | 6 | 10 | |
| No | 23 | 33 | 0.797 |
| Drinking history | |||
| Yes | 6 | 11 | |
| No | 23 | 32 | 0.632 |
| Differentiation | |||
| Highly differentiation | 5 | 6 | |
| Medium differentiation | 19 | 32 | |
| Low differentiation | 5 | 5 | 0.040 |
| Tumor site | |||
| Upper thoracic portion | 4 | 11 | |
| Middle thoracic portion | 15 | 21 | |
| Low thoracic portion | 10 | 11 | 0.047 |
| Histology | |||
| Squamous | 27 | 41 | |
| Nonsquamous | 1 | 0 | |
| Small cell | 1 | 2 | 0.802 |
| T-staging | |||
| T1 + T2 | 12 | 18 | |
| T3 + T4 | 17 | 25 | 0.968 |
| N-staging | |||
| N0 | 13 | 16 | |
| N1 + N2 | 16 | 27 | 0.518 |
| Nutriture | |||
| Benign | 15 | 17 | |
| Unbenign | 14 | 26 | 0.307 |
| Anemic state | |||
| Not anemic | 7 | 15 | |
| Anemia | 22 | 28 | 0.332 |
| Coagulation state | |||
| Normal | 20 | 33 | |
| Abnormal | 9 | 10 | 0.463 |
| ECOG score | |||
| 0 point | 22 | 22 | |
| 1 point | 7 | 15 | |
| 2 point | 0 | 6 | 0.035 |
| Treatment efficacy | |||
| CR + PR | 26 | 21 | |
| SD + PD | 3 | 22 | 0.000 |
Basic physiological and physiological characteristics of 72 patients
| Characteristic | No of patents (%) |
|---|---|
| All patients (%) | 72 (100%) |
| Sex | |
| Female | 24 (33.3%) |
| Male | 48 (66.7%) |
| Age | |
| Mean-SD | 64 years |
| Range | 52-98 |
| 64-year old or older | 61 (84.7%) |
| Under 64-year old | 11 (15.3%) |
| History of smoking | |
| Yes | 16 (22.2%) |
| No | 56 (77.8%) |
| Drinking history | |
| Yes | 17 (23.6%) |
| No | 55 (76.4%) |
| Differentiation | |
| Highly differentiation | 11 (15.3%) |
| Medium differentiation | 51 (70.8%) |
| Low differentiation | 10 (13.9%) |
| Tumor site | |
| Upper thoracic portion | 15 (20.8%) |
| Middle thoracic portion | 36 (50.0%) |
| Low thoracic portion | 21 (29.2%) |
| Histology | |
| Squamous | 68 (94.4%) |
| Non-squamous | 1 (1.4%) |
| Small cell | 3 (4.2%) |
| T-staging | |
| T1 + T2 | 30 (41.7%) |
| T3 + T4 | 42 (58.3%) |
| N-staging | |
| N0 | 29 (40.3%) |
| N1 + N2 | 43 (59,7%) |
| Nutriture | |
| Benign | 32 (44.4%) |
| Unbenign | 40 (55.6%) |
| Anemic state | |
| Not anemic | 51 (70.8%) |
| Anemia | 21 (29.2%) |
| Coagulation state | |
| Normal | 63 (87.5%) |
| Abnormal | 9 (12.5%) |
| ECOG score | |
| 0 point | 44 (61.1%) |
| 1 point | 22 (30.6%) |
| 2 point | 6 (8.3%) |