Vertebral body collapse after spine stereotactic body radiation therapy: a single-center institutional experience
Article Category: Research Article
Publicado en línea: 12 jun 2024
Páginas: -
Recibido: 26 dic 2023
Aceptado: 26 abr 2024
DOI: https://doi.org/10.2478/raon-2024-0033
Palabras clave
© 2024 Arsh Issany et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Background
Spine stereotactic body radiation therapy (SBRT) for the treatment of metastatic disease is increasingly utilized owing to improved pain and local control over conventional regimens. Vertebral body collapse (VBC) is an important toxicity following spine SBRT. We investigated our institutional experience with spine SBRT as it relates to VBC and spinal instability neoplastic score (SINS).
Patients and methods
Records of 83 patients with 100 spinal lesions treated with SBRT between 2007 and 2022 were reviewed. Clinical information was abstracted from the medical record. The primary endpoint was post-treatment VBC. Logistic univariate analysis was performed to identify clinical factors associated with VBC.
Results
Median dose and number of fractions used was 24 Gy and 3 fractions, respectively. There were 10 spine segments that developed VBC (10%) after spine SBRT. Median time to VBC was 2.4 months. Of the 11 spine segments that underwent kyphoplasty prior to SBRT, none developed subsequent VBC. No factors were associated with VBC on univariate analysis.
Conclusions
The rate of vertebral body collapse following spine SBRT is low. Prophylactic kyphoplasty may provide protection against VBC and should be considered for patients at high risk for fracture.