Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases
Categoría del artículo: Research Article
Publicado en línea: 21 feb 2024
Páginas: 87 - 98
Recibido: 25 ago 2023
Aceptado: 13 sept 2023
DOI: https://doi.org/10.2478/raon-2024-0009
Palabras clave
© 2024 Ana Mervic et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Background
Asbestos exposure has been proposed as a risk factor for shorter telomere length. The aim of our study was to investigate whether telomere length in leukocytes and
Subjects and methods
We conducted two retrospective studies. In the first study, a case-control study, telomere length and
Results
Patients with MM had shorter telomere length than subjects with pleural plaques (p < 0.001). After adjustment for age, rs2736098 CT, and rs10069690 TT and CT+TT genotypes were significantly associated with a higher risk of MM (padj = 0.023; padj = 0.026 and padj = 0.017), while rs2736100 AA and CA+AA genotypes conferred to a lower risk for MM compared to all other subjects (padj = 0.017, and padj = 0.026). Telomere length was not associated with a response to chemotherapy (p > 0.05) or time to disease progression (p > 0.05). Carriers of one or two polymorphic rs10069690 T alleles had a good response to chemotherapy (p = 0.039, and p = 0.048), these associations remained statistically significant after adjustment for age (padj = 0.019; padj = 0.017). Carriers of two polymorphic rs2736100 A alleles had a longer time to disease progression (p = 0.038).
Conclusions
Shorter telomere length and