Clinical impacts of copy number variations in B-cell differentiation and cell cycle control genes in pediatric B-cell acute lymphoblastic leukemia: a single centre experience
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Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, et al. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the children’s oncology group. Blood 2018; 132: 815-24. doi: 10.1182/blood-2018-04-841676RobertsKGReshmiSCHarveyRCChenIMPatelKStonerockEet alGenomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the children’s oncology groupBlood20181328152410.1182/blood-2018-04-841676Open DOISearch in Google Scholar
Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group. J Clin Oncol 2012; 30: 1663-9. doi: 10.1200/JCO.2011.37.8018HungerSPLuXDevidasMCamittaBMGaynonPSWinickNJet alImproved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology groupJ Clin Oncol2012301663910.1200/JCO.2011.37.8018Open DOISearch in Google Scholar
Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 2014; 64: 83-103. doi: 10.3322/caac.21219WardEDeSantisCRobbinsAKohlerBJemalAChildhood and adolescent cancer statistics, 2014CA Cancer J Clin2014648310310.3322/caac.21219Open DOISearch in Google Scholar
Einsiedel HG, Von Stackelberg A, Hartmann R, Fengler R, Schrappe M, Janka-Schaub G, et al. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial Acute Lymphoblastic Leukemia-Relapse Study of the Berlin-Frankfurt-Münster Group 87. J Clin Oncol 2005; 23: 7942-50. doi: 10.1200/JCO.2005.01.1031EinsiedelHGVonStackelberg AHartmannRFenglerRSchrappeMJanka-SchaubGet alLong-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial Acute Lymphoblastic Leukemia-Relapse Study of the Berlin-Frankfurt-Münster Group 87J Clin Oncol20052379425010.1200/JCO.2005.01.1031Open DOISearch in Google Scholar
Olsson L, Ivanov Öfverholm II, Norén-Nyström U, Zachariadis V, Nordlund J, Sjögren H, et al. The clinical impact of IKZF1 deletions in paediatric B-cell precursor acute lymphoblastic leukaemia is independent of minimal residual disease stratification in Nordic Society for Paediatric Haematology and Oncology treatment protocols used between 1992 aand 1993. Br J Haematol 2015; 170: 847-58. doi: 10.1111/bjh.13514OlssonLIvanovÖfverholm IINorén-NyströmUZachariadisVNordlundJSjögrenHet alThe clinical impact of IKZF1 deletions in paediatric B-cell precursor acute lymphoblastic leukaemia is independent of minimal residual disease stratification in Nordic Society for Paediatric Haematology and Oncology treatment protocols used between 1992 aand 1993Br J Haematol20151708475810.1111/bjh.13514Open DOISearch in Google Scholar
Dörge P, Meissner B, Zimmermann M, Möricke A, Schrauder A, Bouquin JP, et al. IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol. Haematologica 2013; 98: 428-32. doi: 10.3324/haematol.2011.056135DörgePMeissnerBZimmermannMMörickeASchrauderABouquinJPet alIKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocolHaematologica2013984283210.3324/haematol.2011.056135Open DOISearch in Google Scholar
Asai D, Imamura T, Suenobu S, Saito A, Hasegawa D, Deguchi T, et al. IKZF 1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan. Cancer Med 2013; 2: 412-9. doi: 10.1002/cam4.87AsaiDImamuraTSuenobuSSaitoAHasegawaDDeguchiTet alIKZF 1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in JapanCancer Med20132412910.1002/cam4.87Open DOISearch in Google Scholar
Kuiper RP, Waanders E, Van Der Velden VHJ, Van Reijmersdal SV, Venkatachalam R, Scheijen B, et al. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010; 24: 1258-64. doi: 10.1038/leu.2010.87KuiperRPWaandersEVanDer Velden VHJVanReijmersdal SVVenkatachalamRScheijenBet alIKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALLLeukemia20102412586410.1038/leu.2010.87Open DOISearch in Google Scholar
Mullighan CG, Su X, Zhang J, Radtke I, Phillips LAA, Miller CB, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009; 360: 470-80. doi: 10.1056/NEJMoa0808253MullighanCGSuXZhangJRadtkeIPhillipsLAAMillerCBet alDeletion of IKZF1 and prognosis in acute lymphoblastic leukemiaN Engl J Med20093604708010.1056/NEJMoa0808253Open DOISearch in Google Scholar
Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S, et al. The ikaros gene is required for the development of all lymphoid lineages. Cell 1994; 79: 143-56. doi: 10.1016/0092-8674(94)90407-3GeorgopoulosKBigbyMWangJHMolnarAWuPWinandySet alThe ikaros gene is required for the development of all lymphoid lineagesCell1994791435610.1016/0092-8674(94)90407-3Open DOISearch in Google Scholar
Molnar A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, et al. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol 1996; 156: 585-92. PMID: 8543809MolnarAWuPLargespadaDAVortkampASchererSCopelandNGet alThe Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouseJ Immunol199615658592PMID: 854380910.4049/jimmunol.156.2.585Search in Google Scholar
Yang YL, Hung CC, Chen JS, Lin KH, Jou ST, Hsiao CC, et al. IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan. Cancer Sci 2011; 102: 1874-81. doi: 10.1111/j.1349-7006.2011.02031.xYangYLHungCCChenJSLinKHJouSTHsiaoCCet alIKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in TaiwanCancer Sci201110218748110.1111/j.1349-7006.2011.02031.x21740479Open DOISearch in Google Scholar
Van Der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal S V., Russell LJ, et al. Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL. Blood 2013; 122: 2622-9. doi: 10.1182/blood-2012-10-462358VanDer Veer AWaandersEPietersRWillemseMEVanReijmersdal S VRussellLJet alIndependent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALLBlood20131222622910.1182/blood-2012-10-462358379546123974192Open DOISearch in Google Scholar
Moorman A V., Enshaei A, Schwab C, Wade R, Chilton L, Elliott A, et al. A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia. Blood 2014; 124: 1434-44. doi: 10.1182/blood-2014-03-562918MoormanA V.EnshaeiASchwabCWadeRChiltonLElliottAet alA novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemiaBlood201412414344410.1182/blood-2014-03-56291824957142Open DOISearch in Google Scholar
Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008; 453: 110-14. doi: 10.1038/nature06866MullighanCGMillerCBRadtkeIPhillipsLADaltonJMaJet alBCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of IkarosNature20084531101410.1038/nature0686618408710Open DOISearch in Google Scholar
Van Der Veer A, Zaliova M, Mottadelli F, De Lorenzo P, Te Kronnie G, Harrison CJ, et al. IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL. Blood 2014; 123: 1691-8. doi: 10.1182/blood-2013-06-509794VanDer Veer AZaliovaMMottadelliFDe LorenzoPTeKronnie GHarrisonCJet alIKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALLBlood20141231691810.1182/blood-2013-06-50979424366361Open DOISearch in Google Scholar
Roberts KG. The biology of Philadelphia chromosome-like ALL. Best Pract Res Clin Haematol 2017; 30: 212-21. doi: 10.1016/j.beha.2017.07.003RobertsKGThe biology of Philadelphia chromosome-like ALLBest Pract Res Clin Haematol2017302122110.1016/j.beha.2017.07.00329050694Open DOISearch in Google Scholar
Boer JM, Van Der Veer A, Rizopoulos D, Fiocco M, Sonneveld E, De Groot-Kruseman HA, et al. Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study. Leukemia 2016; 30: 32-38. doi: 10.1038/leu.2015.199BoerJMVanDer Veer ARizopoulosDFioccoMSonneveldEDe Groot-KrusemanHAet alPrognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative studyLeukemia201630323810.1038/leu.2015.19926202931Open DOISearch in Google Scholar
Steeghs EMP, Boer JM, Hoogkamer AQ, Boeree A, de Haas V, de Groot-Kruseman HA, et al. Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia. Sci Rep 2019; 9: 1-11. doi: 10.1038/s41598-019-41078-4SteeghsEMPBoerJMHoogkamerAQBoereeAde HaasVde Groot-KrusemanHAet alCopy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemiaSci Rep2019911110.1038/s41598-019-41078-4642065930874617Open DOISearch in Google Scholar
Stanulla M, Cavé H, Moorman A V. IKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker? Blood 2020; 135: 252-60. doi: 10.1182/blood.2019000813StanullaMCavéHMoormanA VIKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker?Blood20201352526010.1182/blood.2019000813701903531821407Open DOISearch in Google Scholar
Stanulla M, Dagdan E, Zaliova M, Möricke A, Palmi C, Cazzaniga G, et al. IKZF1 plus defines a new minimal residual disease-dependent very-poor prognostic profile in pediatric b-cell precursor acute lymphoblastic leukemia. J Clin Oncol 2018; 36: 1240-9. doi: 10.1200/JCO.2017.74.3617StanullaMDagdanEZaliovaMMörickeAPalmiCCazzanigaGet alIKZF1 plus defines a new minimal residual disease-dependent very-poor prognostic profile in pediatric b-cell precursor acute lymphoblastic leukemiaJ Clin Oncol2018361240910.1200/JCO.2017.74.361729498923Open DOISearch in Google Scholar
Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, et al. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet 2019; 51: 296-307. doi: 10.1038/s41588-018-0315-5GuZChurchmanMLRobertsKGMooreIZhouXNakitandweJet alPAX5-driven subtypes of B-progenitor acute lymphoblastic leukemiaNat Genet20195129630710.1038/s41588-018-0315-5652530630643249Open DOISearch in Google Scholar
Schwab C, Nebral K, Chilton L, Leschi C, Waanders E, Boer JM, et al. Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia? Blood Adv 2017; 1: 1473-7. doi: 10.1182/bloodadvances.2017006734SchwabCNebralKChiltonLLeschiCWaandersEBoerJMet alIntragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?Blood Adv201711473710.1182/bloodadvances.2017006734572846229296789Open DOISearch in Google Scholar
Zhang W, Kuang P, Liu T. Prognostic significance of CDKN2A/B deletions in acute lymphoblastic leukaemia: a meta-analysis. Ann Med 2019; 51: 28-40. doi: 10.1080/07853890.2018.1564359ZhangWKuangPLiuTPrognostic significance of CDKN2A/B deletions in acute lymphoblastic leukaemia: a meta-analysisAnn Med201951284010.1080/07853890.2018.1564359785747330592434Open DOISearch in Google Scholar
Carrasco Salas P, Fernández L, Vela M, Bueno D, González B, Valentín J, et al. The role of CDKN2A/B deletions in pediatric acute lymphoblastic leukemia. Pediatr Hematol Oncol 2016; 33: 415-22. doi: 10.1080/08880018.2016.1251518CarrascoSalas PFernándezLVelaMBuenoDGonzálezBValentínJet alThe role of CDKN2A/B deletions in pediatric acute lymphoblastic leukemiaPediatr Hematol Oncol2016334152210.1080/08880018.2016.125151827960642Open DOISearch in Google Scholar
Zhang W, Kuang P, Liu T. Prognostic significance of CDKN2A/B deletions in acute lymphoblastic leukaemia: a meta-analysis. Ann Med 2019; 51: 28-40. doi: 10.1080/07853890.2018.1564359ZhangWKuangPLiuTPrognostic significance of CDKN2A/B deletions in acute lymphoblastic leukaemia: a meta-analysisAnn Med201951284010.1080/07853890.2018.1564359Open DOISearch in Google Scholar
Yamashita Y, Shimada A, Yamada T, Yamaji K, Hori T, Tsurusawa M, et al. IKZF1 and CRLF2 gene alterations correlate with poor prognosis in japanese BCR-ABL1-negative high-risk B-cell precursor acute. Pediatr Blood Cancer 2013; 60: 1587-92. doi: 10.1002/pbcYamashitaYShimadaAYamadaTYamajiKHoriTTsurusawaMet alIKZF1 and CRLF2 gene alterations correlate with poor prognosis in japanese BCR-ABL1-negative high-risk B-cell precursor acutePediatr Blood Cancer20136015879210.1002/pbcOpen DOISearch in Google Scholar
Palmi C, Valsecchi MG, Longinotti G, Silvestri D, Carrino V, Conter V, et al. What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia? Haematologica 2013; 98: 1226-31. doi: 10.3324/haematol.2012.075432PalmiCValsecchiMGLonginottiGSilvestriDCarrinoVConterVet alWhat is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?Haematologica20139812263110.3324/haematol.2012.075432372990223585525Open DOISearch in Google Scholar
Clappier E, Grardel N, Bakkus M, Rapion J, De Moerloose B, Kastner P, et al. IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children’s Leukemia Group study 58951. Leukemia 2015; 29: 2154-61. doi: 10.1038/leu.2015.134ClappierEGrardelNBakkusMRapionJDe MoerlooseBKastnerPet alIKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children’s Leukemia Group study 58951Leukemia20152921546110.1038/leu.2015.13426050650Open DOISearch in Google Scholar
Vrooman LM, Blonquist TM, Harris MH, Stevenson KE, Place AE, Hunt SK, et al. Refining risk classification in childhood b acute lymphoblastic leukemia: results of DFCI ALL consortium protocol 05-001. Blood Adv 2018; 2: 144958. doi: 10.1182/bloodadvances.2018016584VroomanLMBlonquistTMHarrisMHStevensonKEPlaceAEHuntSKet alRefining risk classification in childhood b acute lymphoblastic leukemia: results of DFCI ALL consortium protocol 05-001Blood Adv2018214495810.1182/bloodadvances.2018016584602080629941458Open DOISearch in Google Scholar
Öfverholm I, Tran AN, Heyman M, Zachariadis V, Nordenskjöld M, Nordgren A, et al. Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols. Leukemia 2013; 27: 1936-9. doi: 10.1038/leu.2013.92ÖfverholmITranANHeymanMZachariadisVNordenskjöldMNordgrenAet alImpact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocolsLeukemia2013271936910.1038/leu.2013.9223538749Open DOISearch in Google Scholar
Schwab CJ, Jones LR, Morrison H, Ryan SL, Yigittop H, Schouten JP, et al. Evaluation of multiplex ligation-dependent probe amplification as a method for the detection of copy number abnormalities in B-cell precursor acute lymphoblastic leukemia. Genes Chromosom Cancer 2010; 49: 1104-13. doi: 10.1002/gccSchwabCJJonesLRMorrisonHRyanSLYigittopHSchoutenJPet alEvaluation of multiplex ligation-dependent probe amplification as a method for the detection of copy number abnormalities in B-cell precursor acute lymphoblastic leukemiaGenes Chromosom Cancer20104911041310.1002/gccOpen DOISearch in Google Scholar
Schwab CJ, Chilton L, Morrison H, Jones L, Al-Shehhi H, Erhorn A, et al. Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features. Haematologica 2013; 98: 1081-8. doi: 10.3324/haematol.2013.085175SchwabCJChiltonLMorrisonHJonesLAl-ShehhiHErhornAet alGenes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical featuresHaematologica2013981081810.3324/haematol.2013.085175369661223508010Open DOISearch in Google Scholar
Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758-64. doi: 10.1038/nature05690MullighanCGGoorhaSRadtkeIMillerCBCoustan-SmithEDaltonJDet alGenome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaNature20074467586410.1038/nature0569017344859Open DOISearch in Google Scholar
Kim M, Choi JE, She CJ, Hwang SM, Shin HY, Ahn HS, et al. PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia. Blood Cells, Mol Dis 2011; 47: 62-6. doi: 10.1016/j.bcmd.2011.04.003KimMChoiJESheCJHwangSMShinHYAhnHSet alPAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemiaBlood Cells, Mol Dis20114762610.1016/j.bcmd.2011.04.00321549623Open DOISearch in Google Scholar
Kawamata N, Ogawa S, Zimmermann M, Sanada M, Hemminki K, Yamatomo G, et al. Rearrangement and deletion of the PAX5 gene in pediatric acute B-cell lineage lymphoblastic leukemia. Blood 2007; 110: 981. doi: 10.1182/blood.V110.11.981.981KawamataNOgawaSZimmermannMSanadaMHemminkiKYamatomoGet alRearrangement and deletion of the PAX5 gene in pediatric acute B-cell lineage lymphoblastic leukemiaBlood200711098110.1182/blood.V110.11.981.981Open DOISearch in Google Scholar
Kim M, Choi JE, She CJ, Hwang SM, Shin HY, Ahn HS, et al. PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia. Blood Cells, Mol Dis 2011; 47: 62-6. doi: 10.1016/j.bcmd.2011.04.003KimMChoiJESheCJHwangSMShinHYAhnHSet alPAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemiaBlood Cells, Mol Dis20114762610.1016/j.bcmd.2011.04.003Open DOISearch in Google Scholar
Paulsson K, Johansson B. High Hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosom Cancer 2009; 48: 637-60. doi: 10.1002/gcc.20671PaulssonKJohanssonBHigh Hyperdiploid childhood acute lymphoblastic leukemiaGenes Chromosom Cancer2009486376010.1002/gcc.2067119415723Open DOISearch in Google Scholar
Palmi C, Vendramini E, Silvestri D, Longinotti G, Frison D, Cario G, et al. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. Leukemia 2012; 26: 2245-53. doi: 10.1038/leu.2012.101PalmiCVendraminiESilvestriDLonginottiGFrisonDCarioGet alPoor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemiaLeukemia20122622455310.1038/leu.2012.10122484421Open DOISearch in Google Scholar