Skin | MIBT | CK | p-value* |
---|---|---|---|
D0.1cm3 | 75.3 (18.0−164.2) | 88.8 (27.6−112.4) | 0.0080 |
D0.2cm3 | 70.3 (17.4−140.7) | 86.8 (21.1−111.1) | 0.0053 |
D1cm3 | 58.4 (15.0−97.1) | 79 (22.8−106.0) | 0.0007 |
D0.1cm3 | 53.7 (8.1−92.7) | 78.9 (17.6−108.4) | 0.0003 |
D1cm3 | 43.1 (5.3−76.4) | 69.1 (16.4−105) | 0.0004 |
V100 (cm3) | 0 (0−0) | 0.2 (0.0−3.0) | 0.0101 |
V50 (cm3) | 2 (0.0−16.4) | 4.2 (0.0−13.4) | 0.0105 |
Method of treatment | Laterality | Upper outer | Lower outer | Upper inner | Lower inner | Central |
---|---|---|---|---|---|---|
MIBT | right | 3 | 1 | 3 | 2 | 4 |
left | 3 | 3 | 4 | 1 | 8 | |
CK | right | 6 | 6 | 2 | 1 | 2 |
left | 2 | 4 | 1 | 3 | 5 |
MIBT | CK | p-value* | |
---|---|---|---|
V100 | 9.7 (2.2−29.7) | 9.6 (0.9−20.4) | 0.9381 |
V50 | 23.2 (5.1−68.0) | 23.3 (2.7−47.1) | 0.9822 |
V100 | 1.6 (0.4−4.2) | 0.7 (0.0−2.0) | < 0.0001 |
V90 | 2.8 (0.6−8.1) | 2.3 (0.0−4.4) | 0.7019 |
V50 | 12.9 (3.1−35.4) | 10.5 (1.7−18.9) | 0.5501 |
V25 | 31.8 (9.4−68.4) | 29.9 (7.6−55.2) | 0.8772 |
Ipsilateral lung | MIBT | CK | p-value* |
---|---|---|---|
Mean lung dose | 4.9 (1.9−11.1) | 4.9 (1.6−11.8) | 0.9946 |
D0.1cm3 | 41.0 (10.1−61.5) | 52.2 (15.6−90.5) | 0.0068 |
D1cm3 | 36.1 (8.7−55.8) | 45.4 (14.4−84.5) | 0.0162 |
D2cm3 | 33.6 (8−52.5) | 42.2 (13.7−80.5) | 0.0198 |
D2 | 21.2 (7.4−32.9) | 24 (8.8−46.4) | 0.2454 |
V5 | 30.6 (5.1−50.0) | 30.7 (5.8−63.2) | 0.9357 |
Heart | MIBT | CK | p-value* |
---|---|---|---|
Mean heart dose | 4.1 (1.0−7.7) | 3.3 (1.3−6.9) | 0.1706 |
D0.1cm3 | 21.4 (4.0−47.2) | 18.9 (8.4−43.2) | 0.2822 |
D1cm3 | 18.2 (3.2−42.3) | 16.6 (7.3−40.3) | 0.4878 |
D2cm3 | 17 (3.0−40.0) | 15.6 (6.8−38.3) | 0.5324 |
D2 | 13.3 (4.3−26.4) | 12.5 (5.2−31.5) | 0.5098 |
V5 | 29.9 (0.0−62.5) | 21.2 (6.1−41.0) | 0.1653 |
Body | MIBT | CK | p-value* |
---|---|---|---|
V100 (cm3) | 66.4 (28.9−193.8) | 77.1 (18.3−141.5) | 0.0356 |
V50 (cm3) | 159.0 (73.4−444.2) | 189.3 (58.6−397.6) | 0.0184 |
V20 (cm3) | 470.7 (253.4−1078.1) | 609.1 (326.7−1160.8) | 0.0013 |
Contralateral breast | MIBT | CK | p-value* |
---|---|---|---|
D0.1cm3 | 4 (0.0−9.8) | 2.1 (0.3−11.2) | 0.0039 |
D1cm3 | 2.6 (0.0−6.4) | 1.8 (0.3−9.9) | 0.0378 |
D0.1cm3 | 5.5 (0.0−11.7) | 3 (1.0−5.6) | 0.0000 |
D1cm3 | 3.6 (0.0−8.3) | 2.5 (0.6−4.8) | 0.0228 |
Publication | Xu 201225 | Vermeulen 201451 | Goggin 201526 | Rault 201627 | Obayomi 201652 | Lozza 201853 | Bonfantini 201828 | Lee 201829 | Lee 202054 | Fröhlich 202036 | Current study |
---|---|---|---|---|---|---|---|---|---|---|---|
Patient number | 14 | 21 | 9 | 10 | 10 | 20 | 10 | 10 | 103 | 25 | 32 |
Applicator | Cones | - | Iris, MLC | Iris | - | Iris | Iris | Cones | - | MLC | MLC |
Beam number | - | 151 | - , - | - | 155 | 180 | 122 | - | - | - | 40 (57)@ |
Fractionation | 10 x 3.85 Gy | 10 x 3.4 Gy | 5 x 6 Gy | 10 x 4 Gy | 5 x 6 Gy | 6 5 Gy x | 5 x 6 Gy | 5 x 6 Gy | 5 x 6 Gy | 4 x 6.25 Gy | 4 x 6.25 Gy |
Treatment Time (min) | - | 46 | 28, 14.7 | 40 | - | 60 | 60 | 60 | 33# | - | 33.3 |
CTV-PTV margin (mm) | 2 | 2 | 2 | 3 | 5 | 5 | 5 | 2 | 0 | 2 | 2 |
Mean PTV volume (cm3) | - | 114 | - | - | 70 | 88.1 | 121.6 | 37.7 | 73.6 | 71.6 | 71.7 |
Ipsilateral breast | |||||||||||
V100 (%) | 7# | 12 | 12.5, 12.2 | 14 | 28.7 | 10 | - | 9.6 | |||
V50 (%) | 22.4# | 26 | 25.8, 24.2 | 31 | 75 | 24 | 35.5# | 23.3 | |||
Ipsilateral non-target breast | |||||||||||
V100 (%) | 9 | - | 1.7 | - | 0.7 | ||||||
V50 (%) | 23.1 | 17.6 | 16.3 | - | 10.5 | 10.5 | |||||
Ipsilateral lung | |||||||||||
V30 (%) | 1.3 | 1.9, 1.6 | 2.3 | 2.1 | 2.2# | 1.0 | |||||
V5 (%) | 31.4# | 39.4, 17.9 | 30.7 | ||||||||
mean dose (%) | 4.9 | ||||||||||
D0.1cm3 | 57.5 | 52.2 | |||||||||
D1cm3 | 45 | 45.4 | |||||||||
Heart | |||||||||||
V5 (%) | 9.4 | 10 | 3.9 | 31 | 14 | 23.2 | 23 | - | 21.2 | ||
mean dose (%) | 2.3# | 3.3 | |||||||||
D0.1cm3 | 12.1 | 18.9 | |||||||||
D1cm3 | 10.5 | 16.6 | |||||||||
Skin | |||||||||||
Dmax (%) | - | 108.8 | - | - | 106.6 | 98.2 | 94.7 | 103.3 | 88.7# | 99.6* | 88.8* |
Contralateral breast | |||||||||||
Dmax (%) | 1.6 | 3 | - | - | 10 | - | - | 10 | 2.7# | 3.8* | 2.1* |