The role of polymorphisms in glutathione-related genes in asbestos-related diseases

The study investigated the influence of GCLC, GCLM, GSTM1, GSTT1 and GSTP1 polymorphisms, as well as the influence of interactions between polymorphism and interactions between polymorphisms and asbestos exposure, on the risk of developing pleural plaques, asbestosis and malignant mesothelioma (MM).

Subjects and methods

The cross sectional study included 940 asbestos-exposed subjects, among them 390 subjects with pleural plaques, 147 subjects with asbestosis, 225 subjects with MM and 178 subjects with no asbestos-related disease. GCLC rs17883901, GCLM rs41303970, GSTM1 null, GSTT1 null, GSTP1 rs1695 and GSTP1 rs1138272 genotypes were determined using PCR based methods. In statistical analysis, logistic regression was used.

Results

GSTT1 null genotype was associated with the decreased risk for pleural plaques (OR = 0.63; 95% CI = 0.40–0.98; p = 0.026) and asbestosis (OR = 0.51; 95% CI = 0.28–0.93; p = 0.028), but not for MM. A positive association was found between GSTP1 rs1695 AG + GG vs. AA genotypes for MM when compared to pleural plaques (OR = 1.39; 95% CI = 1.00–1.94; p = 0.049). The interactions between different polymorphisms showed no significant influence on the risk of investigated asbestos-related diseases. The interaction between GSTT1 null polymorphism and asbestos exposure decreased the MM risk (OR = 0.17; 95% CI = 0.03–0.85; p = 0.031).

Conclusions

Our findings suggest that GSTT1 null genotype may be associated with a decreased risk for pleural plaques and asbestosis, may modify the association between asbestos exposure and MM and may consequently act protectively on MM risk. This study also revealed a protective effect of the interaction between GSTP1 rs1695 polymorphism and asbestos exposure on MM risk.

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Temas de la revista:: Medicina, Medicina Clínica, Medicina Interna, Hematología, oncología, Radiología

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The role of polymorphisms in glutathione-related genes in asbestos-related diseases

Alenka Franko

Katja Goricar

Metoda Dodic Fikfak

Viljem Kovac

Vita Dolzan

Categoría del artículo: Research Article

Publicado en línea: 26 ene 2021

Páginas: 179 - 186

Recibido: 09 nov 2020

Aceptado: 02 dic 2020

DOI: https://doi.org/10.2478/raon-2021-0002

Palabras clavepolymorphisms, glutathione-related genes, asbestos, asbestosis, pleural plaques, malignant mesothelioma

© 2021 Alenka Franko, Katja Goricar, Metoda Dodic Fikfak, Viljem Kovac, Vita Dolzan, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background

Subjects and methods

Results

Conclusions

Palabras clave
polymorphisms, glutathione-related genes, asbestos, asbestosis, pleural plaques, malignant mesothelioma