A new instrument for predicting survival of patients with cerebral metastases from breast cancer developed in a homogeneously treated cohort

Figure 1

Univariate analyses of overall survival (OS); p-values were received from the Wilcoxon test_

Characteristic	OS at 3 months (%)	OS at 6 months (%)	OS at 9 months (%)	OS at 12 months (%)	P-value
Age
≤61 years	58	39	30	24
≥62 years	47	28	22	15	0.076
Karnofsky performance score
<70%	26	8	5
70%	54	32	19
>70%	89	72	60	51	<0.001
Time between first diagnosis of breast cancer
and WBRT
≤33 months	46	29	22	18
≥34 months	59	38	29	21	0.062
Systemic treatment prior to WBRT
No	45	23	11	11
Yes	53	35	28	21	0.27
Number of cerebral lesions
1-3	46	35	27	18
≥4	55	33	36	20	0.43
Controlled primary tumor
No	33	25	25	25
Yes	54	34	26	19	0.18
Extra-cerebral metastatic disease
No	76	53	43	36
Yes	45	28	21	15	0.001
Entire cohort	52	34	26	20

Distribution of the patient characteristics

Characteristic	Number of patients	Proportion (%)
Age
≤61 years	85	50
≥62 years	85	50
Karnofsky performance score
<70%	76	45
70%	41	24
>70%	53	31
Time between first diagnosis of breast cancer and
WBRT
≤33 months	85	50
≥34 months	85	50
Systemic treatment prior to WBRT
No	22	13
Yes	148	87
Number of cerebral lesions
1-3	52	31
≥4	118	69
Controlled primary tumor
No	12	7
Yes	158	93
Extra-cerebral metastatic disease
No	38	22
Yes	132	78

Six-month overall survival rates (OS) of the characteristics included in the WBRT-30-BC and the related scoring points

Characteristic	6-month OS rate (%)	Scoring points
Karnofsky performance score
<70%	8	1
70%	32	3
>70%	72	7
Time between first diagnosis of breast cancer and WBRT
≤33 months	29	3
≥34 months	38	4
Extra-cerebral metastatic disease
No	53	5
Yes	28	3

Overall survival (OS) rates of the four prognostic groups at 3, 6, 9 and 12 months following WBRT; the p-value was received from the Wilcoxon test

Prognostic group	OS at 3 months (%)	OS at 6 months (%)	OS at 9 months (%)	OS at 12 months (%)	P-value
6-9 points	25	8	5	2
10-12 points	69	41	25	0
13-15 points	87	68	54	47
16 points	100	100	100	83	<0.001