<abstract xmlns="http://www.w3.org/1999/xhtml"> Background. Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. Case report. We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life. Conclusions. Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.</abstract>

Background. Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. Case report. We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life. Conclusions. Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region

Department of Otolaryngology Head Neck Surgery, Section of Pathology, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy

Institute of Dermatology, Section of Pathology, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy

Department of Molecular Medicine, Section of Pathology, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy

Radiology and Oncology

Background. Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis,...

Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region

Publicado en línea: 08 oct 2013

Páginas: 366 - 369

DOI: https://doi.org/10.2478/raon-2013-0059

Palabras clave
electrochemotherapy, head and neck cancer, Merkel cell carcinoma, palliative treatment

This content is open access.

Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region

Publicado en línea: 08 oct 2013

Páginas: 366 - 369

DOI: https://doi.org/10.2478/raon-2013-0059

Palabras claveelectrochemotherapy, head and neck cancer, Merkel cell carcinoma, palliative treatment

This content is open access.

Palabras clave
electrochemotherapy, head and neck cancer, Merkel cell carcinoma, palliative treatment