Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests
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09 mar 2023
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Publicado en línea: 09 mar 2023
Páginas: 49 - 52
Recibido: 25 abr 2022
Aceptado: 10 nov 2022
DOI: https://doi.org/10.2478/prolas-2023-0006
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© 2023 Elīna Ļeonova et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.