<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as a barrier to allergens, pathogens, and toxins. Leaky gut syndrome is defined as a gut mucosal barrier dysfunction, which results in abnormally increased intestinal permeability. Research shows that leaky gut syndrome (LGS) has a pathogenetic relationship with a series of gastrointestinal and extra-intestinal disorders. This review discusses the current understanding of intestinal barrier composition and pathological contribution of LGS to various diseases. The major aim of this paper is to review different methods for diagnostics and evaluation of intestinal wall permeability, identifying their priorities and disadvantages.</p>
</abstract>

Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as a barrier to allergens, pathogens, and toxins. Leaky gut syndrome is defined as a gut mucosal barrier dysfunction, which results in abnormally increased intestinal permeability. Research shows that leaky gut syndrome (LGS) has a pathogenetic relationship with a series of gastrointestinal and extra-intestinal disorders. This review discusses the current understanding of intestinal barrier composition and pathological contribution of LGS to various diseases. The major aim of this paper is to review different methods for diagnostics and evaluation of intestinal wall permeability, identifying their priorities and disadvantages.

Establishing the cut-offs of leaky gut syndrome diagnostic: where are we now?

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Establishing the cut-offs of leaky gut syndrome diagnostic: where are we now?"}

Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as a barrier...

Establishing the cut-offs of leaky gut syndrome diagnostic: where are we now?

Publicado en línea: 10 dic 2022

Páginas: 569 - 577

DOI: https://doi.org/10.2478/prolas-2022-0089

Palabras clave
leaky gut, intestinal barrier, gut permeability, microbiota

© 2022 Jekaterina Rodina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Establishing the cut-offs of leaky gut syndrome diagnostic: where are we now?

Publicado en línea: 10 dic 2022

Páginas: 569 - 577

DOI: https://doi.org/10.2478/prolas-2022-0089

Palabras claveleaky gut, intestinal barrier, gut permeability, microbiota

© 2022 Jekaterina Rodina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
leaky gut, intestinal barrier, gut permeability, microbiota