<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Type-2 diabetes (T2D) is a chronic condition, generally regarded as an irreversible, that is among the top 10 causes of death globally. The hallmark of T2D is hyperglycemia, which results from disturbances in insulin sensitivity, insulin secretion, β-cell dysfunction and insulin resistance. Several clinical and lifestyle factors are involved in the progression of T2D, such as obesity and physical inactivity. A high-calorie diet is the main contributor to the development of obesity, which results in T2D, as obesity or increased intra-abdominal adipose tissue is related to insulin resistance. Technological advances have contributed to individuals having a more sedentary lifestyle, leading to obesity and T2D. T2D can be treated with lifestyle interventions, such as diet and exercise. Herein, we highlight the positive impact of a very low-calorie diet (VLCD) and lifestyle modalities in the treatment and prevention of T2D. An inclusion of VLCD 400-800 kcal/day for 8 weeks and ≥ 150 minutes exercise 5 times a week as lifestyle interventions can decrease glucose levels to normal, reduce HbA1c and improve insulin resistance and sensitivity. Therefore, a potential mechanism in maintaining glucose homeostasis and remission of T2D by VLCD and exercise reduces body weight.</p></abstract>

Type-2 diabetes (T2D) is a chronic condition, generally regarded as an irreversible, that is among the top 10 causes of death globally. The hallmark of T2D is hyperglycemia, which results from disturbances in insulin sensitivity, insulin secretion, β-cell dysfunction and insulin resistance. Several clinical and lifestyle factors are involved in the progression of T2D, such as obesity and physical inactivity. A high-calorie diet is the main contributor to the development of obesity, which results in T2D, as obesity or increased intra-abdominal adipose tissue is related to insulin resistance. Technological advances have contributed to individuals having a more sedentary lifestyle, leading to obesity and T2D. T2D can be treated with lifestyle interventions, such as diet and exercise. Herein, we highlight the positive impact of a very low-calorie diet (VLCD) and lifestyle modalities in the treatment and prevention of T2D. An inclusion of VLCD 400-800 kcal/day for 8 weeks and ≥ 150 minutes exercise 5 times a week as lifestyle interventions can decrease glucose levels to normal, reduce HbA1c and improve insulin resistance and sensitivity. Therefore, a potential mechanism in maintaining glucose homeostasis and remission of T2D by VLCD and exercise reduces body weight.

Effect of Calorie Restriction and Exercise on Type 2 Diabetes

Department of Nutrition and Health, College of Medicine and Health Sciences

Department of Medicine-Western Health, Melbourne Medical School

Department of Clinical Nutrition and Dietetics, College of Health Sciences

Nuffield Department of Women’s & Reproductive Health

PRILOZI

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Effect of Calorie Restriction and Exercise on Type 2 Diabetes"}

Type-2 diabetes (T2D) is a chronic condition, generally regarded as an irreversible, that is among the top 10 causes of death globally. The hallmark of T2D is...

Effect of Calorie Restriction and Exercise on Type 2 Diabetes

Publicado en línea: 23 abr 2021

Páginas: 109 - 126

DOI: https://doi.org/10.2478/prilozi-2021-0010

Palabras clave
Hyperglycemia, very low-calorie diet, insulin sensitivity, insulin resistance, type 2 diabetes

© 2021 Hira Shakoor et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effect of Calorie Restriction and Exercise on Type 2 Diabetes

Publicado en línea: 23 abr 2021

Páginas: 109 - 126

DOI: https://doi.org/10.2478/prilozi-2021-0010

Palabras claveHyperglycemia, very low-calorie diet, insulin sensitivity, insulin resistance, type 2 diabetes

© 2021 Hira Shakoor et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
Hyperglycemia, very low-calorie diet, insulin sensitivity, insulin resistance, type 2 diabetes