<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Aim</bold>:To determine whether there is an immunogenic connection and antigen difference between the HLA antigens in the erosive (EOLP) and reticular (ROLP) oral lichen planus.<bold>Materials and Method</bold>: 73 patients with ROLP and EOLP have been tested. Typing of the HLA antigens has been made for locus A and B. The typing of the HLA was conducted with the use of microlymphocyto toxic test by Terasaki. The reading of the findings has been conducted with an inverse microscope. When a reaction has 4 points it is considered to be positive.<bold>Results</bold>: The most frequently typified antigens in ROLP from locus A are HLA А2 (57.57%) and А3 (33.33)%, and for locus B 21.21%. In EOLP it is А9 (8888%). In locus B a connection has been found with HLA B8 (77.77%). The statistical analysis with the ×2 test has shown that the carriers of HLA A9 display a relative risk (RR) of 3.65 and ×2=20.72. Consequently, there is high static importance for locus A p&lt;0,001. For locus B, In EOLP for HLA B8, RR=6. 7 ×2=37.64 and p&lt;0,001. ROLP has shown association with HLA A3, where RR=2. 31 and ×2 =9.14 and p&lt;0.05.<bold>Conclusions</bold>: In ROLP A3 antigen and in EOLP A9 and A8 may be considered as carriers with proneness to OLP.</abstract>

Aim:To determine whether there is an immunogenic connection and antigen difference between the HLA antigens in the erosive (EOLP) and reticular (ROLP) oral lichen planus.Materials and Method: 73 patients with ROLP and EOLP have been tested. Typing of the HLA antigens has been made for locus A and B. The typing of the HLA was conducted with the use of microlymphocyto toxic test by Terasaki. The reading of the findings has been conducted with an inverse microscope. When a reaction has 4 points it is considered to be positive.Results: The most frequently typified antigens in ROLP from locus A are HLA А2 (57.57%) and А3 (33.33)%, and for locus B 21.21%. In EOLP it is А9 (8888%). In locus B a connection has been found with HLA B8 (77.77%). The statistical analysis with the ×2 test has shown that the carriers of HLA A9 display a relative risk (RR) of 3.65 and ×2=20.72. Consequently, there is high static importance for locus A p<0,001. For locus B, In EOLP for HLA B8, RR=6. 7 ×2=37.64 and p<0,001. ROLP has shown association with HLA A3, where RR=2. 31 and ×2 =9.14 and p<0.05.Conclusions: In ROLP A3 antigen and in EOLP A9 and A8 may be considered as carriers with proneness to OLP.

Oral Lichen Planus – Related Connection with HLA-System Antigens

Departement of periodontology and oral pathology, Faculty of dentistry

Departement of periodontology and oral pathology

PRILOZI

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Oral Lichen Planus \u2013 Related Connection with HLA-System Antigens"}

Aim:To determine whether there is an immunogenic connection and antigen difference between the HLA antigens in the erosive (EOLP) and reticular (ROLP) oral...

Oral Lichen Planus – Related Connection with HLA-System Antigens

Publicado en línea: 22 jun 2020

Páginas: 65 - 77

DOI: https://doi.org/10.2478/prilozi-2020-0024

Palabras clave
oral lichen planus, erosive, reticular, HLA, squamous-cell carcinoma

© 2020 Mirjana Popovska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Oral Lichen Planus – Related Connection with HLA-System Antigens

Publicado en línea: 22 jun 2020

Páginas: 65 - 77

DOI: https://doi.org/10.2478/prilozi-2020-0024

Palabras claveoral lichen planus, erosive, reticular, HLA, squamous-cell carcinoma

© 2020 Mirjana Popovska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
oral lichen planus, erosive, reticular, HLA, squamous-cell carcinoma