Bronchiectasis: The hidden side of common variable immunodeficiency – Case report
Categoría del artículo: Pneumologia
Publicado en línea: 13 may 2025
Páginas: 47 - 51
DOI: https://doi.org/10.2478/pneum-2025-0008
Palabras clave
© 2024 Nicolae Demenciuc et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1.
Figure 2.
Similarities and differences in ICON and ESID criteria for CVID diagnosis (adaptation from Lee, Theodore K et al_ “State-of-the-art diagnostic evaluation of common variable immunodeficiency_” Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology vol_ 127,1 (2021): 19-27_ doi:10_1016/j_anai_2021_03_005)
| CVID ICON criteria | CVID ESID criteria |
|---|---|
| 5 criteria for CVID diagnosis:
immunoglobulin (Ig) G level less than SD below age-appropriate references for 2 measurements more than 3weeks apart unless the level is very low (<100-300 mg/dL depending on age); no secondary causes of hypogammaglobulinemia. poor antibody responses to vaccination; greater than 4 years of age; either a low IgA or IgM; |
ICON criteria 1 - 4 plus decrease of IgA is required; low switched memory B cells (less than 70% of age-related normal value) can be used instead of measurement of antibody response to vaccine; no evidence of profound T cell deficiency; a clinical manifestation of disease such as an increased susceptibility to infection, autoimmune manifestations, granulomatous disease, or unexplained polyclonal lymphoproliferation, or an affected family member with antibody deficiency |