<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Sarcoidosis is a chronic systemic granulomatous disease that can show overlapping clinical features with various rheumatological entities. Even though it can be more commonly associated with Sjögren syndrome and systemic lupus erythematosus, only on rare occasions, it can concomitantly occur with rheumatoid arthritis. While lacking a gold standard diagnostic tool, sarcoidosis remains an exclusion diagnosis. Moreover, an atypical presentation of a rare disease on the background of another systemic disease can be challenging, even for an experienced physician. We present a rare case of a patient with a long-standing history of rheumatoid arthritis treated with methotrexate who developed sarcoidosis with an unusual presentation and possible cardiac involvement.</p>
</abstract>

Sarcoidosis is a chronic systemic granulomatous disease that can show overlapping clinical features with various rheumatological entities. Even though it can be more commonly associated with Sjögren syndrome and systemic lupus erythematosus, only on rare occasions, it can concomitantly occur with rheumatoid arthritis. While lacking a gold standard diagnostic tool, sarcoidosis remains an exclusion diagnosis. Moreover, an atypical presentation of a rare disease on the background of another systemic disease can be challenging, even for an experienced physician. We present a rare case of a patient with a long-standing history of rheumatoid arthritis treated with methotrexate who developed sarcoidosis with an unusual presentation and possible cardiac involvement.

Diagnostic challenges of a rare disease with an unusual presentation

The State University of Medicine and Pharmacy “Nicolae Testemitanu”

Pneumologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Diagnostic challenges of a rare disease with an unusual presentation"}

Sarcoidosis is a chronic systemic granulomatous disease that can show overlapping clinical features with various rheumatological entities. Even though it can...

Diagnostic challenges of a rare disease with an unusual presentation

Publicado en línea: 17 oct 2023

Páginas: 60 - 66

DOI: https://doi.org/10.2478/pneum-2023-0021

Palabras clave
sarcoidosis, rheumatoid arthritis, overlap, autoimmune

© 2022 Diana Calaras et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Diagnostic challenges of a rare disease with an unusual presentation

Publicado en línea: 17 oct 2023

Páginas: 60 - 66

DOI: https://doi.org/10.2478/pneum-2023-0021

Palabras clavesarcoidosis, rheumatoid arthritis, overlap, autoimmune

© 2022 Diana Calaras et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
sarcoidosis, rheumatoid arthritis, overlap, autoimmune