<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Aims:</bold> To carry out a comprehensive retrospective assessment of the prevalence, features and course of treatment of patients with multidrug-resistant tuberculosis (MDR-TB) and diabetes mellitus (DM).<bold>Materials and Methods:</bold> Our study is based on a retrospective analysis of statistical data obtained from 762 current and former MDR-TB patients (74% of patients with resistance only to first-line drugs – isoniazid (H) and rifampin (R); 36% with resistance to H, R and second-line drugs) included in the register of tuberculosis (TB) patients from different regions of Ukraine and the Grodno region of the Republic of Belarus between 2015 and 2019.<bold>Results and Discussion:</bold> In both groups of the study recurrent TB prevailed: 49 cases (55.7%) of relapse TB compared to 39 cases (44.3%) of primary TB in the main group; 363 cases (53.9%) of relapse TB compared to 311 (46.1%) primary TB in the control group (P &lt; 0.05). The rate of successful treatment in the control group is higher than in the main group (64.7% vs. 61.4%; P &lt; 0.05). A significant difference between the two groups was observed owing to the difference in frequency of treatment, which in the main group has recorded 27.3%, as against 40.3% in the control group (almost two times lower; P &lt; 0.05).<bold>Conclusions:</bold> The association between TB and DM increases the morbidity, chemoresistance and proportion of recurrences. Pulmonary TB developed significantly more often in middle-aged patients with type 2 DM with moderate and severe states, with subcompensated form and with a complicated course.</abstract>

Aims: To carry out a comprehensive retrospective assessment of the prevalence, features and course of treatment of patients with multidrug-resistant tuberculosis (MDR-TB) and diabetes mellitus (DM).Materials and Methods: Our study is based on a retrospective analysis of statistical data obtained from 762 current and former MDR-TB patients (74% of patients with resistance only to first-line drugs – isoniazid (H) and rifampin (R); 36% with resistance to H, R and second-line drugs) included in the register of tuberculosis (TB) patients from different regions of Ukraine and the Grodno region of the Republic of Belarus between 2015 and 2019.Results and Discussion: In both groups of the study recurrent TB prevailed: 49 cases (55.7%) of relapse TB compared to 39 cases (44.3%) of primary TB in the main group; 363 cases (53.9%) of relapse TB compared to 311 (46.1%) primary TB in the control group (P < 0.05). The rate of successful treatment in the control group is higher than in the main group (64.7% vs. 61.4%; P < 0.05). A significant difference between the two groups was observed owing to the difference in frequency of treatment, which in the main group has recorded 27.3%, as against 40.3% in the control group (almost two times lower; P < 0.05).Conclusions: The association between TB and DM increases the morbidity, chemoresistance and proportion of recurrences. Pulmonary TB developed significantly more often in middle-aged patients with type 2 DM with moderate and severe states, with subcompensated form and with a complicated course.

Multidrug-resistant tuberculosis and diabetes mellitus as a problem of modern medicine

Department of phthisiology and pulmonology

University of Medicine and Pharmacy ‘Grigore T. Popa’

Ivano-Frankivsk National Medical University

Pneumologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Aims: To carry out a comprehensive retrospective assessment of the prevalence, features and course of treatment of patients with multidrug-resistant...

Multidrug-resistant tuberculosis and diabetes mellitus as a problem of modern medicine

Publicado en línea: 28 may 2022

Páginas: 26 - 33

DOI: https://doi.org/10.2478/pneum-2022-0006

Palabras clave
multidrug resistance, diabetes mellitus, hydrocarbon metabolism, treatment, epidemiology

© 2021 Liliia Todoriko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Multidrug-resistant tuberculosis and diabetes mellitus as a problem of modern medicine

Publicado en línea: 28 may 2022

Páginas: 26 - 33

DOI: https://doi.org/10.2478/pneum-2022-0006

Palabras clavemultidrug resistance, diabetes mellitus, hydrocarbon metabolism, treatment, epidemiology

© 2021 Liliia Todoriko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
multidrug resistance, diabetes mellitus, hydrocarbon metabolism, treatment, epidemiology