<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Introduction</h3><p>The development of clinical prediction scales and their use can reduce under-diagnosis and increase early detection of chronic obstructive pulmonary disease (COPD). The performance of clinical prediction scales in Colombia is unknown. The objective of this study is to evaluate the validity and reproducibility of the lung function questionnaire (LFQ) in Colombia.</p></sec><sec><h3>Method</h3><p>A cross-sectional study was performed, with analysis of diagnostic validity and reliability in people over 40 years of age who underwent a spirometry test. The LFQ questionnaire was applied. To assess reproducibility, the test was carried out at two time points: first at the initial consultation; and then 1 day to 1 week after the previous application. Spirometry was performed immediately after the initial questionnaire, meeting the American Thoracic Society criteria.</p></sec><sec><h3>Results</h3><p>Among the 1996 subjects included in the analysis, the average age was 65 years (SD: 11.97 years), prevalence of COPD was 21.3%, the intra-class correlation coefficient between the two time points was 0.844 (95% CI: 0.863–0.901) (p &lt; 0.001), and kappa was 0.797 for the dichotomous outcome ≤18 COPD risk points (p &lt; 0.001), validity analysis using the area under the receiver operating characteristic curve for the population evaluated was 0.715 (95% CI: 0.685–0.745); the dichotomous outcome of the questionnaire ≤18 points was as follows: sensitivity – 91.18% (95% CI: 88.0–94.3); specificity – 32.41% (95% CI: 29.8–35.0); positive predictive value – 26.7% (95% CI: 24.1–29.3); negative predictive value – 93.15% (95% CI: 90.7–95.6); likelihood ratio (LR) +: 1.34 (95% CI: 1.28–1.42), LR– 0.27 (95% CI: 0.19–0.39); number needed to diagnose: 4; number needed to misdiagnose: 2 (p &lt; 0.001).</p></sec><sec><h3>Conclusion</h3><p>The LFQ questionnaire has good performance for the diagnosis of COPD, especially in populations without previous respiratory symptoms or usual risk factors, optimising the use of spirometry to increase its detection.</p></sec></abstract>

IntroductionThe development of clinical prediction scales and their use can reduce under-diagnosis and increase early detection of chronic obstructive pulmonary disease (COPD). The performance of clinical prediction scales in Colombia is unknown. The objective of this study is to evaluate the validity and reproducibility of the lung function questionnaire (LFQ) in Colombia.MethodA cross-sectional study was performed, with analysis of diagnostic validity and reliability in people over 40 years of age who underwent a spirometry test. The LFQ questionnaire was applied. To assess reproducibility, the test was carried out at two time points: first at the initial consultation; and then 1 day to 1 week after the previous application. Spirometry was performed immediately after the initial questionnaire, meeting the American Thoracic Society criteria.ResultsAmong the 1996 subjects included in the analysis, the average age was 65 years (SD: 11.97 years), prevalence of COPD was 21.3%, the intra-class correlation coefficient between the two time points was 0.844 (95% CI: 0.863–0.901) (p < 0.001), and kappa was 0.797 for the dichotomous outcome ≤18 COPD risk points (p < 0.001), validity analysis using the area under the receiver operating characteristic curve for the population evaluated was 0.715 (95% CI: 0.685–0.745); the dichotomous outcome of the questionnaire ≤18 points was as follows: sensitivity – 91.18% (95% CI: 88.0–94.3); specificity – 32.41% (95% CI: 29.8–35.0); positive predictive value – 26.7% (95% CI: 24.1–29.3); negative predictive value – 93.15% (95% CI: 90.7–95.6); likelihood ratio (LR) +: 1.34 (95% CI: 1.28–1.42), LR– 0.27 (95% CI: 0.19–0.39); number needed to diagnose: 4; number needed to misdiagnose: 2 (p < 0.001).ConclusionThe LFQ questionnaire has good performance for the diagnosis of COPD, especially in populations without previous respiratory symptoms or usual risk factors, optimising the use of spirometry to increase its detection.

Validation and reproducibility of the lung function questionnaire (LFQ) for the diagnosis of COPD in Colombia

Pneumologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Validarea și reproductibilitatea Lung Function Questionnaire (LFQ) pentru diagnosticul BPOC în Colombia

IntroductionThe development of clinical prediction scales and their use can reduce under-diagnosis and increase early detection of chronic obstructive...

Validation and reproducibility of the lung function questionnaire (LFQ) for the diagnosis of COPD in Colombia

Article Category: Original Papers

Publicado en línea: 27 jul 2020

Páginas: 37 - 46

DOI: https://doi.org/10.2478/pneum-2020-0010

Palabras clave
chronic obstructive pulmonary disease, spirometry, interview and questionnaires, validity and reproducibility

© 2020 Alirio Rodrigo Bastidas Goyes et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Validation and reproducibility of the lung function questionnaire (LFQ) for the diagnosis of COPD in Colombia

Article Category: Original Papers

Publicado en línea: 27 jul 2020

Páginas: 37 - 46

DOI: https://doi.org/10.2478/pneum-2020-0010

Palabras clavechronic obstructive pulmonary disease, spirometry, interview and questionnaires, validity and reproducibility

© 2020 Alirio Rodrigo Bastidas Goyes et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
chronic obstructive pulmonary disease, spirometry, interview and questionnaires, validity and reproducibility