Tk-deleted pseudorabies virus retains high pathogenicity in rats
Categoría del artículo: Review article
Publicado en línea: 26 oct 2021
Páginas: 401 - 405
Recibido: 02 abr 2021
Aceptado: 12 oct 2021
DOI: https://doi.org/10.2478/jvetres-2021-0056
Palabras clave
© 2021 L. Zhang et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Introduction
The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats.
Material and Methods
Sprague Dawley rats were infected with the tk-deleted PRV strain SuHV-1 ΔTK:247
Results
Infection with SuHV-1 ΔTK:247 could cause death in rats. The 50% lethal dose (LD50) of SuHV-1 ΔTK:247
Conclusion
The results of this study show that rats are highly susceptible to PRV infection, and tk deletion did not completely diminish the pathogenicity of PRV in rats.