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Protective effects of bisoprolol against cadmium-induced myocardial toxicity through inhibition of oxidative stress and NF-κΒ signalling in rats

Jinhua Liu

Jinhua Liu

Department of Cardiology, Central Hospital of Wuhan, WuhanHubei, China
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Liu, Jinhua
, 
Ying Xie

Ying Xie

Department of Infectious Diseases, Yanbian University Hospital, YanjiJilin, China
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Xie, Ying
, 
Zhujun Han

Zhujun Han

Department of Cardiology, Yanbian University Hospital, YanjiJilin, China
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Han, Zhujun
, 
Hailong Wang

Hailong Wang

Department of Cardiology, Yanbian University Hospital, YanjiJilin, China
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Wang, Hailong
 y 
Wenhu Xu

Wenhu Xu

Department of Cardiology, Yanbian University Hospital, YanjiJilin, China
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Xu, Wenhu
  
20 oct 2021
Protective effects of bisoprolol against cadmium-induced myocardial toxicity through inhibition of oxidative stress and NF-κΒ signalling in rats's Cover Image
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Categoría del artículo: Review article
Publicado en línea: 20 oct 2021
Páginas: 505 - 511
Recibido: 27 mar 2021
Aceptado: 30 sept 2021
DOI: https://doi.org/10.2478/jvetres-2021-0054
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© 2021 J. Liu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1a

Mean arterial pressure (MAP) in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Mean arterial pressure (MAP) in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 1b

Serum creatine kinase-MB (CK-MB) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Serum creatine kinase-MB (CK-MB) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 1c

Serum lactic acid dehydrogenase (LDH) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Serum lactic acid dehydrogenase (LDH) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 1d

Serum alanine aminotransferase (ALT) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Serum alanine aminotransferase (ALT) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 1e

Serum aspartate aminotransferase (AST) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Serum aspartate aminotransferase (AST) levels in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 2

Malondialdehyde (MDA) levels in cardiac tissue from rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Malondialdehyde (MDA) levels in cardiac tissue from rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 3

Tumour necrosis factor alpha (TNF-α) from cardiac tissue of rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Tumour necrosis factor alpha (TNF-α) from cardiac tissue of rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significant difference versus the control group; ** P < 0.001 for significant difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 4a

Cardiac tissue homogenate NF-κB- p65/β-actin expression from Western blot analysis in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significance difference versus the control group; ** P < 0.001 for significance difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Cardiac tissue homogenate NF-κB- p65/β-actin expression from Western blot analysis in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significance difference versus the control group; ** P < 0.001 for significance difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 4b

Cardiac tissue homogenate GST/β-actin expression from Western blot analysis in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significance difference versus the control group; ** P < 0.001 for significance difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)
Cardiac tissue homogenate GST/β-actin expression from Western blot analysis in rats treated with cadmium and bisoprolol (BIS) (2 and 8 mg/kg/day). Values are expressed as mean ± SEM (n = 9). *** P < 0.0001 for significance difference versus the control group; ** P < 0.001 for significance difference versus the Cd-treated group (using one-way ANOVA, including Dunnett’s test)

Fig. 5

Effect of bisoprolol on cadmium-induced cardiotoxicity. I – the control group showing normally preserved cardiac muscle architecture; II – the cadmium-treated group showing subendocardial necrosis with no muscle striations, pyknotic nuclei and vascular congestion; III – the cadmium and 2 mg/kg BIS-treated group showing moderate improvement with congestion and no muscle striations; IV – the cadmium and 8 mg/kg BIS-treated group showing marked improvement with mild congestion
Effect of bisoprolol on cadmium-induced cardiotoxicity. I – the control group showing normally preserved cardiac muscle architecture; II – the cadmium-treated group showing subendocardial necrosis with no muscle striations, pyknotic nuclei and vascular congestion; III – the cadmium and 2 mg/kg BIS-treated group showing moderate improvement with congestion and no muscle striations; IV – the cadmium and 8 mg/kg BIS-treated group showing marked improvement with mild congestion

Quantitative data on the cardiac tissue antioxidant enzymes in rats treated with cadmium and BIS (2 and 8 mg/kg/day)

Parameter Control Cadmium BIS (2 mg/kg) BIS (8 mg/kg)
SOD (unit of SOD/g tissue) 41.5 ± 3.67 19.81 ± 0.67 *** 21.1 ± 3.12 # 36.76 ± 1.89 **
CAT (mmol/min/g tissue) 3.32 ± 1.64 2.897 ± 0.34 *** 2.521 ± 0.22 # 3.167 ± 0.289 **
LPO (nmol hydroperoxides/g tissue) 894.3 ± 14.61 1639 ± 56.23 *** 1556.5 ± 45.23# 823.8 ± 18.13**
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Temas de la revista:
Ciencias de la vida, Biología molecular, Microbiología y virología, Ciencias de la vida, otros, Medicina, Medicina veterinaria
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