<abstract xmlns="http://www.w3.org/1999/xhtml">
<sec id="j_jvetres-2021-0031_s_005">
<h3>Introduction</h3>
<p>The aim of the study was to demonstrate a link between uncomplicated <italic>Babesia canis</italic> infection in dogs and blood concentrations of zinc and copper and erythrocytic antioxidant defence – activities of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT).</p></sec>
<sec id="j_jvetres-2021-0031_s_006">
<h3>Material and Methods</h3>
<p>The study was based on 15 naturally occurring cases of canine babesiosis with anorexia, pyrexia, depression, pale mucous membrane, splenomegaly and dark red urine. Microscopic examination of Giemsa-stained peripheral blood smears and the results of PCR confirmed <italic>B. canis</italic> infection. Seven apparently healthy dogs brought in for either a check-up or vaccination were used for comparison.</p></sec>
<sec id="j_jvetres-2021-0031_s_007">
<h3>Results</h3>
<p>The levels of the erythrocytic antioxidant enzymes - SOD and CAT - were significantly higher in the infected dogs than in cytologically negative dogs. The levels of blood micronutrients were significantly lower in the infected dogs (0.478 μg of zinc per mL <italic>vs</italic> 1.241 μg/mL and 0.722 μg of copper per mL <italic>vs</italic> 1.392 μg/mL).</p></sec>
<sec id="j_jvetres-2021-0031_s_008">
<h3>Conclusion</h3>
<p>Oxidative stress can be posited as one of the mechanisms leading to anaemia in dogs with babesiosis, and therefore antioxidant biomarker and copper and zinc concentrations could be used as indicators of disease severity and prognostic markers.</p></sec>


</abstract>

Introduction
The aim of the study was to demonstrate a link between uncomplicated Babesia canis infection in dogs and blood concentrations of zinc and copper and erythrocytic antioxidant defence – activities of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT).

Material and Methods
The study was based on 15 naturally occurring cases of canine babesiosis with anorexia, pyrexia, depression, pale mucous membrane, splenomegaly and dark red urine. Microscopic examination of Giemsa-stained peripheral blood smears and the results of PCR confirmed B. canis infection. Seven apparently healthy dogs brought in for either a check-up or vaccination were used for comparison.

Results
The levels of the erythrocytic antioxidant enzymes - SOD and CAT - were significantly higher in the infected dogs than in cytologically negative dogs. The levels of blood micronutrients were significantly lower in the infected dogs (0.478 μg of zinc per mL vs 1.241 μg/mL and 0.722 μg of copper per mL vs 1.392 μg/mL).

Conclusion
Oxidative stress can be posited as one of the mechanisms leading to anaemia in dogs with babesiosis, and therefore antioxidant biomarker and copper and zinc concentrations could be used as indicators of disease severity and prognostic markers.

Antioxidant status, and blood zinc and copper concentrations in dogs with uncomplicated babesiosis due to <italic>Babesia canis</italic> infections

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antioxidant status, and blood zinc and copper concentrations in dogs with uncomplicated babesiosis due to  infections

Introduction
The aim of the study was to demonstrate a link between uncomplicated Babesia canis infection in dogs and blood concentrations of zinc and copper...

Antioxidant status, and blood zinc and copper concentrations in dogs with uncomplicated babesiosis due to Babesia canis infections

Publicado en línea: 08 jun 2021

Páginas: 169 - 174

Recibido: 02 dic 2020

Aceptado: 18 may 2021

DOI: https://doi.org/10.2478/jvetres-2021-0031

Palabras clave
copper, zinc, superoxide dismutase, catalase

© 2021 O. Teodorowski et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antioxidant status, and blood zinc and copper concentrations in dogs with uncomplicated babesiosis due to Babesia canis infections

Publicado en línea: 08 jun 2021

Páginas: 169 - 174

Recibido: 02 dic 2020

Aceptado: 18 may 2021

DOI: https://doi.org/10.2478/jvetres-2021-0031

Palabras clavecopper, zinc, superoxide dismutase, catalase

© 2021 O. Teodorowski et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
copper, zinc, superoxide dismutase, catalase