<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2019-0052_s_005">
<h3>Introduction</h3>
<p>The miniature pig possesses unmatched advantages as an animal model because of its high homology with humans. Our experiment aimed to build a chronic renal failure (CRF) model in pigs <italic>via</italic> laparoscopy.</p></sec>
<sec id="j_jvetres-2019-0052_s_006">
<h3>Material and Methods</h3>
<p>Laparoscopic surgery was performed twice to build a CRF model. The first surgery was a left partial nephrectomy and the second was a right radical nephrectomy. Pigs were grouped by the total renal tissue to be resected: ⅔, ¾ or ⅚. Physiological parameters (rectal temperature and heart rate), haematological parameters (WBC and RBC) and renal function (serum creatinine – CR and blood urea nitrogen – BUN) were measured preoperatively and every week postoperatively.</p></sec>
<sec id="j_jvetres-2019-0052_s_007">
<h3>Results</h3>
<p>After renal resection the pigs manifested chronic renal failure. Heart rate and body temperature declined to varying degrees over 12 postoperative weeks. No significant difference was observed between the different groups. The result of renal function tests found that postoperative serum CR and BUN in all groups were continuously elevated, and the level of serum CR at two weeks post procedure differed very significantly from its preoperative value (P &lt; 0.05). BUN was significantly elevated at one week (P &lt; 0.05). The renal function decreased significantly faster in the ⅚ group than in the other two groups. The trend of renal function change was similar among groups, but progress was slower in the ⅔ and ¾ groups.</p></sec>
<sec id="j_jvetres-2019-0052_s_008">
<h3>Conclusion</h3>
<p>⅚ kidney resection was the optimal miniature pig model of CRF.</p></sec>
</abstract>

Introduction
The miniature pig possesses unmatched advantages as an animal model because of its high homology with humans. Our experiment aimed to build a chronic renal failure (CRF) model in pigs via laparoscopy.

Material and Methods
Laparoscopic surgery was performed twice to build a CRF model. The first surgery was a left partial nephrectomy and the second was a right radical nephrectomy. Pigs were grouped by the total renal tissue to be resected: ⅔, ¾ or ⅚. Physiological parameters (rectal temperature and heart rate), haematological parameters (WBC and RBC) and renal function (serum creatinine – CR and blood urea nitrogen – BUN) were measured preoperatively and every week postoperatively.

Results
After renal resection the pigs manifested chronic renal failure. Heart rate and body temperature declined to varying degrees over 12 postoperative weeks. No significant difference was observed between the different groups. The result of renal function tests found that postoperative serum CR and BUN in all groups were continuously elevated, and the level of serum CR at two weeks post procedure differed very significantly from its preoperative value (P < 0.05). BUN was significantly elevated at one week (P < 0.05). The renal function decreased significantly faster in the ⅚ group than in the other two groups. The trend of renal function change was similar among groups, but progress was slower in the ⅔ and ¾ groups.

Conclusion
⅚ kidney resection was the optimal miniature pig model of CRF.

Establishment of renal failure models by laparoscopy in bama pigs which underwent partial nephrectomy and radical contralateral nephrectomy

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction
The miniature pig possesses unmatched advantages as an animal model because of its high homology with humans. Our experiment aimed to build a...

Establishment of renal failure models by laparoscopy in bama pigs which underwent partial nephrectomy and radical contralateral nephrectomy

Publicado en línea: 13 sept 2019

Páginas: 447 - 455

Recibido: 24 dic 2018

Aceptado: 06 ago 2019

DOI: https://doi.org/10.2478/jvetres-2019-0052

Palabras clave
miniature pig, chronic renal failure, animal model, laparoscopy, nephrectomy

© 2019 H.-F. Liu et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Establishment of renal failure models by laparoscopy in bama pigs which underwent partial nephrectomy and radical contralateral nephrectomy

Publicado en línea: 13 sept 2019

Páginas: 447 - 455

Recibido: 24 dic 2018

Aceptado: 06 ago 2019

DOI: https://doi.org/10.2478/jvetres-2019-0052

Palabras claveminiature pig, chronic renal failure, animal model, laparoscopy, nephrectomy

© 2019 H.-F. Liu et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
miniature pig, chronic renal failure, animal model, laparoscopy, nephrectomy