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Use of a conical conducting layer with an electrical impedance probe to enhance sensitivity in epithelial tissues

Muhammad Abdul Kadir

Muhammad Abdul Kadir

Department of Biomedical Physics and Technology, University of DhakaDhaka, Bangladesh
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Kadir, Muhammad Abdul
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K. Siddique-e Rabbani

K. Siddique-e Rabbani

Department of Biomedical Physics and Technology, University of DhakaDhaka, Bangladesh
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Rabbani, K. Siddique-e
  
31 dic 2018
Use of a conical conducting layer with an electrical impedance probe to enhance sensitivity in epithelial tissues's Cover Image
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Publicado en línea: 31 dic 2018
Páginas: 176 - 183
Recibido: 18 dic 2018
DOI: https://doi.org/10.2478/joeb-2018-0022
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© 2018 M.A. Kadir, K.S. Rabbani published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig.1

Schematic of current density vectors at point P for two pairs of electrodes AB and CD placed on the surface of a volume conductor.
Schematic of current density vectors at point P for two pairs of electrodes AB and CD placed on the surface of a volume conductor.

Fig. 2

Schematic representation of the effect of an interposed conducting layer through imaginary current line patterns: a) for a 2D infinite layer, b) for a conical finite layer, giving rise to virtual electrodes with reduced separation.
Schematic representation of the effect of an interposed conducting layer through imaginary current line patterns: a) for a 2D infinite layer, b) for a conical finite layer, giving rise to virtual electrodes with reduced separation.

Fig.3

FEM model of biological tissue for computation of impedance sensitivity. Four 1 mm dia cylindrical electrodes with edge to edge separation of 1 mm (centre to centre separation: 2 mm) are placed centrally on a surface of a cubic volume conductor with 50 mm sides. The green layer of thickness 300 μm represents an epithelial layer. A zoomed view of the electrodes is shown at the bottom.
FEM model of biological tissue for computation of impedance sensitivity. Four 1 mm dia cylindrical electrodes with edge to edge separation of 1 mm (centre to centre separation: 2 mm) are placed centrally on a surface of a cubic volume conductor with 50 mm sides. The green layer of thickness 300 μm represents an epithelial layer. A zoomed view of the electrodes is shown at the bottom.

Fig.4

Cylindrical conducting layer material placed in between the electrodes and the epithelial layer. The green layer of thickness 300 μm represents an epithelial layer.
Cylindrical conducting layer material placed in between the electrodes and the epithelial layer. The green layer of thickness 300 μm represents an epithelial layer.

Fig.5

Conical shaped conducting layer placed in between the electrodes and tissue surface.
Conical shaped conducting layer placed in between the electrodes and tissue surface.

Fig.6

Variation of plane average sensitivity along depth with different conducting layer (bolus) height for edge to edge electrode separation of 1mm. Depth zero indicates the surface of the volume conductor with or without the interposing conducting layer (probe).
Variation of plane average sensitivity along depth with different conducting layer (bolus) height for edge to edge electrode separation of 1mm. Depth zero indicates the surface of the volume conductor with or without the interposing conducting layer (probe).

Fig.7

Fractional impedance of the epithelial layer compared to the whole tissue as a function of the height of conducting layer. Edge-edge electrode separation is 1 mm.
Fractional impedance of the epithelial layer compared to the whole tissue as a function of the height of conducting layer. Edge-edge electrode separation is 1 mm.

Fig.8

Fractional contribution of the epithelial layer to the total transfer impedance against radii ratio of the conical conducting layer for different conducting layer height. Edge to edge electrode separation is 1 mm.
Fractional contribution of the epithelial layer to the total transfer impedance against radii ratio of the conical conducting layer for different conducting layer height. Edge to edge electrode separation is 1 mm.

Fig.9

Fractional contribution of the epithelial layer to the total transfer impedance against radii ratio of the conical conducting layer for different conducting layer height. Edge to edge electrode separation 2mm.
Fractional contribution of the epithelial layer to the total transfer impedance against radii ratio of the conical conducting layer for different conducting layer height. Edge to edge electrode separation 2mm.

Fig.10

Variation of fractional impedance of the epithelial layer with conical bolus radii ratio for different electrode separations (edge to edge) while the bolus height was constant at 1.2 mm.
Variation of fractional impedance of the epithelial layer with conical bolus radii ratio for different electrode separations (edge to edge) while the bolus height was constant at 1.2 mm.
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Ingeniería, Bioingeniería e ingeniería biomédica, Electrónica biomédica, Ciencias de la vida, Biofísica, Medicina, Ingeniería biomédica, Física, Espectroscopia y metrología
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