<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Gold electrodes are often not suitable for dopamine measurements as dopamine creates a non-conducting polymer layer on the surface of the electrodes, which leads to increased amount of electrode passivity with the gradual increase in voltammograms measurement. This work presents the impedance spectroscopy and cyclic-voltammetry comparative study for dopamine detection with two modifications for the surface of Au electrodes; cysteamine and mercaptopropionic acid for thermally bonded and ultrasonically welded microfluidic chips, respectively. The effects of optimized tubing selection, bonding techniques, and cleaning methods of the devices with KOH solution played crucial role for improvements in dopamine detection, which are observed in the results. Furthermore, comparison for the modification with unmodified chips, and finding the unknown concentration of dopamine solution using flow injection techniques, is also illustrated.</p></abstract>

Gold electrodes are often not suitable for dopamine measurements as dopamine creates a non-conducting polymer layer on the surface of the electrodes, which leads to increased amount of electrode passivity with the gradual increase in voltammograms measurement. This work presents the impedance spectroscopy and cyclic-voltammetry comparative study for dopamine detection with two modifications for the surface of Au electrodes; cysteamine and mercaptopropionic acid for thermally bonded and ultrasonically welded microfluidic chips, respectively. The effects of optimized tubing selection, bonding techniques, and cleaning methods of the devices with KOH solution played crucial role for improvements in dopamine detection, which are observed in the results. Furthermore, comparison for the modification with unmodified chips, and finding the unknown concentration of dopamine solution using flow injection techniques, is also illustrated.

Dopamine detection using mercaptopropionic acid and cysteamine for electrodes surface modification

Journal of Electrical Bioimpedance

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Gold electrodes are often not suitable for dopamine measurements as dopamine creates a non-conducting polymer layer on the surface of the electrodes, which...

Dopamine detection using mercaptopropionic acid and cysteamine for electrodes surface modification

Article Category: Research articles

Publicado en línea: 16 ago 2018

Páginas: 3 - 9

Recibido: 04 feb 2018

DOI: https://doi.org/10.2478/joeb-2018-0002

Palabras clave
dopamine, cyclic-voltammetry, mercaptopropionic acid, microfabrication

© 2018 Khan SK, Asif A, Khawaldeh S, Tekin A, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dopamine detection using mercaptopropionic acid and cysteamine for electrodes surface modification

Article Category: Research articles

Publicado en línea: 16 ago 2018

Páginas: 3 - 9

Recibido: 04 feb 2018

DOI: https://doi.org/10.2478/joeb-2018-0002

Palabras clavedopamine, cyclic-voltammetry, mercaptopropionic acid, microfabrication

© 2018 Khan SK, Asif A, Khawaldeh S, Tekin A, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
dopamine, cyclic-voltammetry, mercaptopropionic acid, microfabrication