Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Index as Predictors of Poor Outcome in Patients with Critical Limb Ischemia Treated with Remote Endarterectomy

1. Conte MS, Bradbury AW, Kolh P, et al. Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia. European Journal of Vascular and Endovascular Surgery. 2019;58:S1-S109.e33. doi: 10.1016/j.ejvs.20196.05.006. Open DOISearch in Google Scholar

2. Jamieson C. The definition of critical ischaemia of a limb. Br J Surg. 1982;69 Suppl:S1.10.1002/bjs.1800691118 Search in Google Scholar

3. Rutherford RB, Baker JD, Ernst C, et al. Recommended standards for reports dealing with lower extremity ischemia: Revised version. Journal of Vascular Surgery. 1997;26:517-538. doi: 10.1016/S0741-5214(97)70045-4. Open DOISearch in Google Scholar

4. Abu Dabrh AM, Steffen MW, Asi N, et al. Bypass surgery versus endovascular interventions in severe or critical limb ischemia. Journal of Vascular Surgery. 2016;63:244-253.e11. doi: 10.1016/j.jvs.2015.07.068.26372187 Open DOISearch in Google Scholar

5. Niculescu R, Russu E, Arbănași EM, et al. Carotid Plaque Features and Inflammatory Biomarkers as Predictors of Restenosis and Mortality Following Carotid Endarterectomy. International Journal of Environmental Research and Public Health. 2022;19:13934. doi: 10.3390/ijerph192113934.965488836360814 Open DOISearch in Google Scholar

6. Cosarca MC, Horváth E, Molnar C, Molnár GB, Russu E, Mureșan VA. Calcification patterns in femoral and carotid atheromatous plaques: A comparative morphometric study. Experimental and Therapeutic Medicine. 2021;22:1-9. doi: 10.3892/etm.2021.10297.822065034178138 Open DOISearch in Google Scholar

7. Cosarca MC, Hălmaciu I, Muresan AV, et al. Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios are associated with amputation rates in patients with peripheral arterial disease and diabetes mellitus who underwent revascularization: A Romanian regional center study. Experimental and Therapeutic Medicine. 2022;24:1-8. doi: 10.3892/etm.2022.11639.962340436337294 Open DOISearch in Google Scholar

8. Russu E, Mureșan AV, Arbănași EM, et al. The Predictive Role of NLR and PLR in Outcome and Patency of Lower Limb Revascularization in Patients with Femoropopliteal Disease. Journal of Clinical Medicine. 2022;11:2620. doi: 10.3390/jcm11092620.910310435566745 Open DOISearch in Google Scholar

9. Mureșan AV, Russu E, Arbănași EM, et al. The Predictive Value of NLR, MLR, and PLR in the Outcome of End-Stage Kidney Disease Patients. Biomedicines. 2022;10:1272. doi: 10.3390/biomedicines10061272.922015935740294 Open DOISearch in Google Scholar

10. Kaller R, Arbănași EM, Mureșan AV, et al. The Predictive Value of Systemic Inflammatory Markers, the Prognostic Nutritional Index, and Measured Vessels’ Diameters in Arteriovenous Fistula Maturation Failure. Life. 2022;12:1447. doi: 10.3390/life12091447.950639536143483 Open DOISearch in Google Scholar

11. Arbănași EM, Mureșan AV, Coșarcă CM, et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Impact on Predicting Outcomes in Patients with Acute Limb Ischemia. Life. 2022;12:822. doi: 10.3390/life12060822.922556535743853 Open DOISearch in Google Scholar

12. Melinte RM, Arbănași EM, Blesneac A, et al. Inflammatory Biomarkers as Prognostic Factors of Acute Deep Vein Thrombosis Following the Total Knee Arthroplasty. Medicina. 2022;58:1502. doi: 10.3390/medicina58101502.960831036295662 Open DOISearch in Google Scholar

13. Arbănași EM, Mureșan AV, Arbănași EM, et al. The Neutrophilto-Lymphocyte Ratio’s Predictive Utility in Acute Pulmonary Embolism: Systematic Review. Journal Of Cardiovascular Emergencies. 2022;8:25-30. doi: 10.2478/jce-2022-0005. Open DOISearch in Google Scholar

14. Vunvulea V, Budișcă OA, Arbănași EM, et al. The Predictive Role of Systemic Inflammatory Markers in the Development of Acute Kidney Failure and Mortality in Patients with Abdominal Trauma. Journal of Personalized Medicine. 2022;12:2045. doi: 10.3390/jpm12122045.978192736556265 Open DOISearch in Google Scholar

15. Halmaciu I, Arbănași EM, Kaller R, et al. Chest CT Severity Score and Systemic Inflammatory Biomarkers as Predictors of the Need for Invasive Mechanical Ventilation and of COVID-19 Patients’ Mortality. Diagnostics. 2022;12:2089. doi: 10.3390/diagnostics12092089.949750936140490 Open DOISearch in Google Scholar

16. Mureșan AV, Hălmaciu I, Arbănași EM, et al. Prognostic Nutritional Index, Controlling Nutritional Status (CONUT) Score, and Inflammatory Biomarkers as Predictors of Deep Vein Thrombosis, Acute Pulmonary Embolism, and Mortality in COVID-19 Patients. Diagnostics. 2022;12:2757. doi: 10.3390/diagnostics12112757.968915036428817 Open DOISearch in Google Scholar

17. Arbănași EM, Halmaciu I, Kaller R, et al. Systemic Inflammatory Biomarkers and Chest CT Findings as Predictors of Acute Limb Ischemia Risk, Intensive Care Unit Admission, and Mortality in COVID-19 Patients. Diagnostics. 2022;12:2379. doi: 10.3390/diagnostics12102379960043436292068 Open DOISearch in Google Scholar

18. Mureșan AV, Russu E, Arbănași EM, et al. Negative Impact of the COVID-19 Pandemic on Kidney Disease Management—A Single-Center Experience in Romania. Journal of Clinical Medicine. 2022;11:2452. doi: 10.3390/jcm11092452.910427835566576 Open DOISearch in Google Scholar

19. Emil-Marian A, Reka K, Vasile Adrian M, Septimiu V, Eliza-Mihaela A, Eliza R. Impact of COVID-19 pandemic on Vascular Surgery Unit activity in Central Romania. Front Surg. 2022;9:883935. doi: 10.3389/fsurg.2022.883935.944581236081587 Open DOISearch in Google Scholar

20. Varma V, Sinibaldi D, Ongstad EL, et al. Abstract 11971: Identification of Response Biomarkers and Signaling Pathways Associated With the LOX-1 Blockade by MEDI6570 in Type 2 Diabetes. Circulation. 2022;146(Suppl_1):A11971-A11971. doi: 10.1161/circ.146.suppl_1.11971. Open DOISearch in Google Scholar

21. Vlad ML, Mares RG, Lazar AG, et al. Monocyte-derived macrophages mediate S100a8/A9-induced oxidative stress and inflammation in the ischemic myocardium. Atherosclerosis. 2022;355:268. doi: 10.1016/j.atherosclerosis.2022.06.1008. Open DOISearch in Google Scholar

22. Zhang Z, Chen Z. Higher Systemic Immune-Inflammation Index is Associated With Higher Likelihood of Peripheral Arterial Disease. Annals of Vascular Surgery. 2022;84:322-326. doi: 10.1016/j.avsg.2021.12.011.34954036 Open DOISearch in Google Scholar

23. Paquissi FC. The role of inflammation in cardiovascular diseases: the predictive value of neutrophil–lymphocyte ratio as a marker in peripheral arterial disease. Ther Clin Risk Manag. 2016;12:851-860. doi: 10.2147/TCRM.S107635.489283327313459 Open DOISearch in Google Scholar

24. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653-657. doi: 10.1016/j.amjcard.2008.05.006.18773982 Open DOISearch in Google Scholar

25. Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta. 2008;395:27-31. doi: 10.1016/j. cca.2008.04.019. Open DOISearch in Google Scholar

26. Akpek M, Kaya MG, Lam YY, et al. Relation of neutrophil/lymphocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Am J Cardiol. 2012;110:621-627. doi: 10.1016/j.amjcard.2012.04.041.22608360 Open DOISearch in Google Scholar

27. Arbel Y, Finkelstein A, Halkin A, et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography. Atherosclerosis. 2012;225:456-460. doi: 10.1016/j.atherosclerosis.2012.09.009.23040448 Open DOISearch in Google Scholar

28. Azab B, Bhatt VR, Phookan J, et al. Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Short- and Long-Term Mortality in Breast Cancer Patients. Ann Surg Oncol. 2012;19:217-224. doi: 10.1245/s10434-011-1814-0.21638095 Open DOISearch in Google Scholar

29. Arbel Y, Shacham Y, Ziv-Baran T, et al. Higher neutrophil/lymphocyte ratio is related to lower ejection fraction and higher long-term all-cause mortality in ST-elevation myocardial infarction patients. Can J Cardiol. 2014;30(:1177-1182. doi: 10.1016/j.cjca.2014.05.010.25154806 Open DOISearch in Google Scholar

30. Turak O, Ozcan F, Isleyen A, et al. Usefulness of the neutrophil-to-lymphocyte ratio to predict bare-metal stent restenosis. Am J Cardiol. 2012;110:1405-1410. doi: 10.1016/j.amjcard.2012.07.003.22858185 Open DOISearch in Google Scholar

31. Taşoğlu I, Turak O, Nazli Y, et al. Preoperative neutrophillymphocyte ratio and saphenous vein graft patency after coronary artery bypass grafting. Clin Appl Thromb Hemost. 2014;20:819-824. doi: 10.1177/1076029613484086.23580624 Open DOISearch in Google Scholar

32. Gibson PH, Croal BL, Cuthbertson BH, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J. 2007;154:995-1002. doi: 10.1016/j.ahj.2007.06.043.17967611 Open DOISearch in Google Scholar

33. Wang X, Zhang G, Jiang X, Zhu H, Lu Z, Xu L. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis. 2014;234:206-213. doi: 10.1016/j.atherosclerosis.2014.03.003.24681815 Open DOISearch in Google Scholar

34. Tokgoz S, Keskin S, Kayrak M, Seyithanoglu A, Ogmegul A. Is neutrophil/lymphocyte ratio predict to short-term mortality in acute cerebral infarct independently from infarct volume? J Stroke Cerebrovasc Dis. 2014;23:2163-2168. doi: 10.1016/j.jstrokecerebrovasdis.2014.04.007.25106834 Open DOISearch in Google Scholar

35. Wang F, Hu S, Ding Y, et al. Neutrophil-to-Lymphocyte Ratio and 30-Day Mortality in Patients with Acute Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2016;25:182-187. doi: 10.1016/j.jstrokecerebrovasdis.2015.09.013.26500171 Open DOISearch in Google Scholar

36. Brooks SD, Spears C, Cummings C, et al. Admission neutrophil–lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy. J Neurointerv Surg. 2014;6:578-583. doi: 10.1136/neurintsurg-2013-010780.437361824122003 Open DOISearch in Google Scholar

37. Hyun S, Kwon S, Cho S, et al. Can the Neutrophil-to-Lymphocyte Ratio Appropriately Predict Carotid Artery Stenosis in Patients with Ischemic Stroke?-A Retrospective Study. J Stroke Cerebrovasc Dis. 2015;24:2646-2651. doi: 10.1016/j.jstrokecerebrovasdis.2015.07.024.26316355 Open DOISearch in Google Scholar

38. Gökhan S, Ozhasenekler A, Mansur Durgun H, Akil E, Ustündag M, Orak M. Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack. Eur Rev Med Pharmacol Sci. 2013;17:653-657. Search in Google Scholar

39. Belaj K, Pichler M, Hackl G, et al. Association of the Derived Neutrophil-Lymphocyte Ratio With Critical Limb Ischemia. Angiology. 2016;67(4):350-354. doi: 10.1177/0003319715590701.26058674 Open DOISearch in Google Scholar

40. Gary T, Pichler M, Belaj K, et al. Neutrophil-to-lymphocyte ratio and its association with critical limb ischemia in PAOD patients. PLoS One. 2013;8:e56745. doi: 10.1371/journal.pone.0056745.357410323457609 Open DOISearch in Google Scholar

41. Luo H, Yuan D, Yang H, et al. Post-treatment neutrophillymphocyte ratio independently predicts amputation in critical limb ischemia without operation. Clinics (Sao Paulo). 2015;70:273-277. doi: 10.6061/clinics/2015(04)09.441835526017794 Open DOISearch in Google Scholar

42. Taşoğlu İ, Sert D, Colak N, Uzun A, Songur M, Ecevit A. Neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio predict the limb survival in critical limb ischemia. Clin Appl Thromb Hemost. 2014;20:645-650. doi: 10.1177/1076029613475474.23393289 Open DOISearch in Google Scholar

43. Kullar P, Weerakoddy R, Walsh S. Neutrophil-Lymphocyte Ratio Predicts Graft Patency Following Lower Limb Revascularisation. Acta Chirurgica Belgica. 2012;112:365-368. doi: 10.1080/00015458.2012.11680853.23175925 Open DOISearch in Google Scholar

44. Erturk M, Cakmak HA, Surgit O, et al. Predictive value of elevated neutrophil to lymphocyte ratio for long-term cardiovascular mortality in peripheral arterial occlusive disease. J Cardiol. 2014;64:371-376. doi: 10.1016/j.jjcc.2014.02.019.24685686 Open DOISearch in Google Scholar

45. Spark JI, Sarveswaran J, Blest N, Charalabidis P, Asthana S. An elevated neutrophil-lymphocyte ratio independently predicts mortality in chronic critical limb ischemia. Journal of Vascular Surgery. 2010;52:632-636. doi: 10.1016/j.jvs.2010.03.067.20573475 Open DOISearch in Google Scholar

46. Chan C, Puckridge P, Ullah S, Delaney C, Spark JI. Neutrophillymphocyte ratio as a prognostic marker of outcome in infrapopliteal percutaneous interventions for critical limb ischemia. Journal of Vascular Surgery. 2014;60:661-668. doi: 10.1016/j.jvs.2014.03.277.24816510 Open DOISearch in Google Scholar

47. González-Fajardo JA, Brizuela-Sanz JA, Aguirre-Gervás B, et al. Prognostic Significance of an Elevated Neutrophil–Lymphocyte Ratio in the Amputation-free Survival of Patients with Chronic Critical Limb Ischemia. Annals of Vascular Surgery. 2014;28:999-1004. doi: 10.1016/j.avsg.2013.06.037.24559786 Open DOISearch in Google Scholar

48. Bhutta H, Agha R, Wong J, Tang TY, Wilson YG, Walsh SR. Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study. Vasc Endovascular Surg. 2011;45:227-231. doi: 10.1177/1538574410396590.21289130 Open DOISearch in Google Scholar

49. Urbanowicz T, Michalak M, Olasińska-Wiśniewska A, et al. Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery. Cells. 2022;11:1124. doi: 10.3390/cells11071124.899759835406687 Open DOISearch in Google Scholar

50. Lee S, Hoberstorfer T, Wadowski PP, Kopp CW, Panzer S, Gremmel T. Platelet-to-lymphocyte and Neutrophil-tolymphocyte Ratios Predict Target Vessel Restenosis after Infrainguinal Angioplasty with Stent Implantation. Journal of Clinical Medicine. 2020;9:1729. doi: 10.3390/jcm9061729.735594432503291 Open DOISearch in Google Scholar

51. Teperman J, Carruthers D, Guo Y, et al. Relationship between neutrophil-lymphocyte ratio and severity of lower extremity peripheral artery disease. Int J Cardiol. 2017;228:201-204. doi: 10.1016/j.ijcard.2016.11.097.846416127865186 Open DOISearch in Google Scholar