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Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects. Pain Physician. 2008 Mar;11(2 Suppl):S105–20.BenyaminRTrescotAMDattaSOpioid complications and side effectsPain Physician2008Mar112 SupplS10520Search in Google Scholar
Vallersnes OM, Jacobsen D, Ekeberg Ø, et al. Mortality, morbidity and follow-up after acute poisoning by substances of abuse: A prospective observational cohort study. Scand J Public Health. 2019 Jun;47(4):452–461.VallersnesOMJacobsenDEkebergØMortality, morbidity and follow-up after acute poisoning by substances of abuse: A prospective observational cohort studyScand J Public Health2019Jun474452461Search in Google Scholar
Earnest JD, Hatch MR, Hurlocker MC. Quality of Life and Opioid Use Motives: Direct and Indirect Associations with Risky Opioid Use in a Community Sample of Adults. Subst Use Misuse. 2022;57(14):2117–2125.EarnestJDHatchMRHurlockerMCQuality of Life and Opioid Use Motives: Direct and Indirect Associations with Risky Opioid Use in a Community Sample of AdultsSubst Use Misuse.2022571421172125Search in Google Scholar
Stein C. The control of pain in peripheral tissue by opioids. N Engl J Med. 1995 Jun 22;332(25):1685–90.SteinCThe control of pain in peripheral tissue by opioidsN Engl J Med1995Jun2233225168590Search in Google Scholar
Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009 Sep;10(9):895–926.LatremoliereAWoolfCJCentral sensitization: a generator of pain hypersensitivity by central neural plasticityJ Pain2009Sep109895926Search in Google Scholar
Schäfer M, Imai Y, Uhl GR et al. Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia. Eur J Pharmacol. 1995 Jun 12;279(2–3):165–9.SchäferMImaiYUhlGRInflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root gangliaEur J Pharmacol1995Jun122792–31659Search in Google Scholar
Stein, C., Machelska, H. and Binder, W et al. Peripheral opioid analgesia. Curr Opin Pharmacol. 2001;1(1), pp. 62–65.SteinC.MachelskaH.BinderWPeripheral opioid analgesiaCurr Opin Pharmacol2001116265Search in Google Scholar
Perrot, S., Guilbaud, G., & Kayser, V. Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammation. Pain, 1999; 83(2), 249–257.PerrotS.GuilbaudG.KayserV.Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammationPain1999832249257Search in Google Scholar
Hassan AH, Ableitner A, Stein C, et al. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience. 1993 Jul;55(1):185–95.HassanAHAbleitnerASteinCInflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissueNeuroscience1993Jul55118595Search in Google Scholar
Sauer RS, Hackel D, Morschel L, et al. Toll like receptor (TLR)-4 as a regulator of peripheral endogenous opioid-mediated analgesia in inflammation. Mol Pain. 2014 Feb 6;10:10.SauerRSHackelDMorschelLToll like receptor (TLR)-4 as a regulator of peripheral endogenous opioid-mediated analgesia in inflammationMol Pain2014Feb61010Search in Google Scholar
Celik MO, Labuz D, Henning K, et al. Leukocyte opioid receptors mediate analgesia via Ca(2+)-regulated release of opioid peptides. Brain Behav Immun. 2016; 57:227–242.CelikMOLabuzDHenningKLeukocyte opioid receptors mediate analgesia via Ca(2+)-regulated release of opioid peptidesBrain Behav Immun201657227242Search in Google Scholar
Cheah M, Fawcett JW, Andrews MR. Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test. Bio Protoc. 2017 Aug 20;7(16):e2506.CheahMFawcettJWAndrewsMRAssessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves TestBio Protoc2017Aug20716e2506Search in Google Scholar
Stein C. Peripheral mechanisms of opioid analgesia. Anesth Analg. 1993 Jan;76(1):182–91.SteinCPeripheral mechanisms of opioid analgesiaAnesth Analg1993Jan76118291Search in Google Scholar
Wood A. New Method of Treating Neuralgia by the Direct Application of Opiates to the Painful Points. Edinb Med Surg J. 1855 Apr 1;82(203):265–281.WoodANew Method of Treating Neuralgia by the Direct Application of Opiates to the Painful PointsEdinb Med Surg J1855Apr182203265281Search in Google Scholar
Millan MJ. Multiple opioid systems and pain. Pain. 1986 Dec;27(3):303–347MillanMJMultiple opioid systems and painPain1986Dec273303347Search in Google Scholar
Stein C. Targeting pain and inflammation by peripherally acting opioids. Front Pharmacol. 2013 Sep 23;4:123.SteinCTargeting pain and inflammation by peripherally acting opioidsFront Pharmacol2013Sep234123Search in Google Scholar
Cayla, C., Labuz, D., Machelska, H., et al. Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptors. Anesthesiology 116. 2012; 448–457.CaylaC.LabuzD.MachelskaH.Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptorsAnesthesiology1162012448457Search in Google Scholar
Stein, C., & Machelska, H. Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy. Pharmacological Reviews. 2011;63(4), 860–881.SteinC.MachelskaH.Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain TherapyPharmacological Reviews2011634860881Search in Google Scholar
Antonijevic I, Mousa SA, Schäfer M et al. Perineurial defect and peripheral opioid analgesia in inflammation. J Neurosci. 1995 Jan;15(1 Pt 1):165–72.AntonijevicIMousaSASchäferMPerineurial defect and peripheral opioid analgesia in inflammationJ Neurosci1995Jan151 Pt 116572Search in Google Scholar
Kalso E, Smith L, McQuay HJ et al. No pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphine. Pain. 2002 Aug;98(3):269–275.KalsoESmithLMcQuayHJNo pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphinePain2002Aug983269275Search in Google Scholar
Vadivelu N, Mitra S, Hines RL. Peripheral opioid receptor agonists for analgesia: a comprehensive review. J Opioid Manag. 2011 Jan–Feb;7(1):55–68.VadiveluNMitraSHinesRLPeripheral opioid receptor agonists for analgesia: a comprehensive reviewJ Opioid Manag2011Jan–Feb715568Search in Google Scholar
Stein, C. Opioid Receptors. Annual Review of Medicine. 2016; 67(1), 433–451.SteinCOpioid ReceptorsAnnual Review of Medicine2016671433451Search in Google Scholar
Ji, R.-R. et al. Expression of μ-, δ-, and κ-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J. Neurosci. 1995; 15, 8156–8166.JiR.-RExpression of μ-, δ-, and κ-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammationJ. Neurosci19951581568166Search in Google Scholar
Stein C, Schäfer M, Machelska H. Attacking pain at its source: new perspectives on opioids. Nat Med. 2003 Aug;9(8):1003–8.SteinCSchäferMMachelskaHAttacking pain at its source: new perspectives on opioidsNat Med2003Aug9810038Search in Google Scholar
Hassan AH, Ableitner A, Stein C, et al. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience. 1993 Jul;55(1):185–95.HassanAHAbleitnerASteinCInflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissueNeuroscience1993Jul55118595Search in Google Scholar
Mousa SA, Zhang Q, Sitte N, et al. Beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. J Neuroimmunol. 2001 Apr 2;115(1–2):71–8.MousaSAZhangQSitteNBeta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissueJ Neuroimmunol2001Apr21151–2718Search in Google Scholar
Fehrenbacher JC, Vasko MR, Duarte DB. Models of inflammation: Carrageenan- or complete Freund’s Adjuvant (CFA)-induced edema and hypersensitivity in the rat. Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.4.FehrenbacherJCVaskoMRDuarteDBModels of inflammation: Carrageenan- or complete Freund’s Adjuvant (CFA)-induced edema and hypersensitivity in the ratCurr Protoc Pharmacol2012MarChapter 5:Unit5.4.Search in Google Scholar
Patil, K.R.; Mahajan, U.B.; Unger, B.S.; et al. Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals. Int. J. Mol. Sci. 2019, 20, 4367.PatilK.R.MahajanU.B.UngerB.S.Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of PhytopharmaceuticalsInt. J. Mol. Sci.2019204367Search in Google Scholar
Stein C., Küchler S. Targeting inflammation and wound healing by opioids. Trends Pharmacol Sci. 2013;Vol 34(6):303–312SteinC.KüchlerS.Targeting inflammation and wound healing by opioidsTrends Pharmacol Sci2013346303312Search in Google Scholar
Fehrenbacher, J. C., Vasko, M. R., & Duarte, D. B. Models of inflammation: Carrageenan- or complete Freund’s Adjuvant (CFA)-induced edema and hypersensitivity in the rat. Current protocols in pharmacology. 2012; Chapter 5, Unit5.4.FehrenbacherJ.C.VaskoM. R.DuarteD. B.Models of inflammation: Carrageenan- or complete Freund’s Adjuvant (CFA)-induced edema and hypersensitivity in the ratCurrent protocols in pharmacology2012Chapter 5, Unit5.4.Search in Google Scholar