Rate of Sodium Correction and Osmotic Demyelination Syndrome in Severe Hyponatremia: A Meta-Analysis

Trial (Study, Year)	Number of patients	Country	Study design	Inclusion criteria	Rapid sodium correction definition	Cases of ODS, n (%)	Diagnosis of ODS
Sterns, 1987	62	USA	Retrospective cohort	Patients with serum sodium concentration of ≤110 mmol/L	The rate of correction to increase the serum sodium to ≥120 mmol/L exceeds 0.55 mmol/L/h	3 (4.8)	Postmortem examination, brainstem auditory evoked responses
Ellis, 1995	184	USA, UK	Retrospective cohort	All adult patients (≥16 years) with serum sodium ≤120 mmol/L at any stage of their hospitalization	>10 mmol/L/24h	1 (0.5)^a	MRI
Vu, 2009	247	Australia	Retrospective cohort	All patients with serum sodium ≤120 mmol/L on admission	>12 mmol/L within the first 24h	4 (1.6)	MRI
Geogheghan, 2015	412	USA	Retrospective cohort	All hospitalized patients with serum sodium ≤120 mmol/L after correction for serum glucose	>10 mmol/L/24h	1 (0.2)	Clinically or radiographically confirmed^b
George, 2018	1490	USA	Retrospective cohort	Adults ≥18 years of age admitted with an initial serum sodium <120mEq/L	>8 mEq/L/24h, >10 mEq/L/24h, or >18 mEq/L/48h^c	9 (0.6)^d	MRI
Mustajoki, 2023	363	Finland	Retrospective cohort	All patients admitted to the ED with plasma sodium concentrations <116 mmol/L	>10 mmol/L/24h	5 (1.4)	MRI
Seethapathy, 2023	3274	USA	Retrospective cohort	Patients (at least 18 years of age) hospitalized with serum sodium level <120mEq/L in the 24 hours preceding or 24 hours after the recorded time of admission	>10 mEq/L/24h	7 (0.2)	MRI

Calendario de la edición:: 4 veces al año
Temas de la revista:: Medicina, Medicina Clínica, Medicina Interna, Medicina Interna, otros, Anestesiología, Medicina de urgencias y cuidados intensivos, Cirugía, Cirugía, otros