<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Objectives</h3>
<p>To evaluate hemodynamic profiles of critical care patients undergoing spontaneous t-piece trial (SBT) and present weaning failure.</p>
</sec>
<sec><h3>Methods</h3>
<p>Prospective observational study conducted in ready-to-wean non-cardiac ICU patients. Clinical, echocardiographic and thermodilution-derived variables were recorded before and after a 2-hour SBT. Weaning from mechanical ventilation was defined as preservation of spontaneous breathing for 48 hours following successful SBT.</p>
</sec>
<sec><h3>Results</h3>
<p>Fourteen patients succeeded weaning, five manifested T-trial-failure and six late-failure. Weaning outcome was significantly associated with ELWI(Extravascular lung-water index), global-end-diastolic index and impaired diastolic function, as indicated by pre-T Doppler early wave velocities (E/Em); Fifty-six percent of participants presented ELWI≥7mL/kg when fulfilling predetermined criteria for weaning. ELWI, impaired pulmonary permeability and left ventricular diastolic dysfunction were independent determinants of ELWI.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>ELWI before SBT and impaired diastolic function (as indicated by pre-T E/Em) might be weaning outcome determinants and their assessment may allow better risk stratification in weaning decision making.</p>
</sec>
</abstract>

Objectives
To evaluate hemodynamic profiles of critical care patients undergoing spontaneous t-piece trial (SBT) and present weaning failure.

Methods
Prospective observational study conducted in ready-to-wean non-cardiac ICU patients. Clinical, echocardiographic and thermodilution-derived variables were recorded before and after a 2-hour SBT. Weaning from mechanical ventilation was defined as preservation of spontaneous breathing for 48 hours following successful SBT.

Results
Fourteen patients succeeded weaning, five manifested T-trial-failure and six late-failure. Weaning outcome was significantly associated with ELWI(Extravascular lung-water index), global-end-diastolic index and impaired diastolic function, as indicated by pre-T Doppler early wave velocities (E/Em); Fifty-six percent of participants presented ELWI≥7mL/kg when fulfilling predetermined criteria for weaning. ELWI, impaired pulmonary permeability and left ventricular diastolic dysfunction were independent determinants of ELWI.

Conclusions
ELWI before SBT and impaired diastolic function (as indicated by pre-T E/Em) might be weaning outcome determinants and their assessment may allow better risk stratification in weaning decision making.

Weaning Outcome is Associated with ELWI and Impaired Diastolic Function

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Weaning Outcome is Associated with ELWI and Impaired Diastolic Function"}

Objectives
To evaluate hemodynamic profiles of critical care patients undergoing spontaneous t-piece trial (SBT) and present weaning...

Weaning Outcome is Associated with ELWI and Impaired Diastolic Function

Article Category: Research Article

Publicado en línea: 30 ene 2024

Páginas: 64 - 72

Recibido: 27 abr 2023

Aceptado: 29 oct 2023

DOI: https://doi.org/10.2478/jccm-2024-0008

Palabras clave
weaning, EVLWI, diastolic dysfuction, critical care, mechanical ventilation

© 2024 Dimitra Bagka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Weaning Outcome is Associated with ELWI and Impaired Diastolic Function

Article Category: Research Article

Publicado en línea: 30 ene 2024

Páginas: 64 - 72

Recibido: 27 abr 2023

Aceptado: 29 oct 2023

DOI: https://doi.org/10.2478/jccm-2024-0008

Palabras claveweaning, EVLWI, diastolic dysfuction, critical care, mechanical ventilation

© 2024 Dimitra Bagka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Palabras clave
weaning, EVLWI, diastolic dysfuction, critical care, mechanical ventilation