<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Data on risk factors associated with mechanical ventilation (MV) weaning failure among SARS-CoV2 ARDS patients is limited. We aimed to determine clinical characteristics associated with weaning outcome in SARS-CoV2 ARDS patients under MV.</p>
</sec>
<sec><h3>Objectives</h3>
<p>To determine potential risk factors for weaning outcome in patients with SARS-CoV2 ARDS.</p>
</sec>
<sec><h3>Methods</h3>
<p>A retrospective observational study was conducted in the ICUs of four Greek hospitals via review of the electronic medical record for the period 2020–2021. All consecutive adult patients were screened and were included if they fulfilled the following criteria: a) age equal or above 18 years, b) need for MV for more than 48 hours and c) diagnosis of ARDS due to SARS-CoV2 pneumonia or primary or secondary ARDS of other aetiologies. Patient demographic and clinical characteristics were recorded for the first 28 days following ICU admission. The primary outcome was weaning success defined as spontaneous ventilation for more than 48 hours.</p>
</sec>
<sec><h3>Results</h3>
<p>A hundred and fifty eight patients were included; 96 SARS-CoV2 ARDS patients. SOFA score, Chronic Obstructive Pulmonary Disease (COPD) and shock were independently associated with the weaning outcome OR(95% CI), 0.86 (0.73–0.99), 0.27 (0.08–0.89) and 0.30 (0.14–0.61), respectively]. When we analysed data from SARS-CoV2 ARDS patients separately, COPD [0.18 (0.03–0.96)] and shock [0.33(0.12 – 0.86)] were independently associated with the weaning outcome.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>The presence of COPD and shock are potential risk factors for adverse weaning outcome in SARS-CoV2 ARDS patients.</p>
</sec>
</abstract>

Background
Data on risk factors associated with mechanical ventilation (MV) weaning failure among SARS-CoV2 ARDS patients is limited. We aimed to determine clinical characteristics associated with weaning outcome in SARS-CoV2 ARDS patients under MV.

Objectives
To determine potential risk factors for weaning outcome in patients with SARS-CoV2 ARDS.

Methods
A retrospective observational study was conducted in the ICUs of four Greek hospitals via review of the electronic medical record for the period 2020–2021. All consecutive adult patients were screened and were included if they fulfilled the following criteria: a) age equal or above 18 years, b) need for MV for more than 48 hours and c) diagnosis of ARDS due to SARS-CoV2 pneumonia or primary or secondary ARDS of other aetiologies. Patient demographic and clinical characteristics were recorded for the first 28 days following ICU admission. The primary outcome was weaning success defined as spontaneous ventilation for more than 48 hours.

Results
A hundred and fifty eight patients were included; 96 SARS-CoV2 ARDS patients. SOFA score, Chronic Obstructive Pulmonary Disease (COPD) and shock were independently associated with the weaning outcome OR(95% CI), 0.86 (0.73–0.99), 0.27 (0.08–0.89) and 0.30 (0.14–0.61), respectively]. When we analysed data from SARS-CoV2 ARDS patients separately, COPD [0.18 (0.03–0.96)] and shock [0.33(0.12 – 0.86)] were independently associated with the weaning outcome.

Conclusions
The presence of COPD and shock are potential risk factors for adverse weaning outcome in SARS-CoV2 ARDS patients.

Risk Factors for Weaning Failure in COVID-19 Patients

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Risk Factors for Weaning Failure in COVID-19 Patients"}

Background
Data on risk factors associated with mechanical ventilation (MV) weaning failure among SARS-CoV2 ARDS patients is limited. We aimed to determine...

Risk Factors for Weaning Failure in COVID-19 Patients

Article Category: Research Article

Publicado en línea: 31 jul 2023

Páginas: 170 - 177

Recibido: 22 oct 2022

Aceptado: 21 jul 2023

DOI: https://doi.org/10.2478/jccm-2023-0021

Palabras clave
COVID-19, weaning, risk factors, shock, COPD, SOFA score, ARDS

© 2023 Effrosyni Gerovasileiou et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Risk Factors for Weaning Failure in COVID-19 Patients

Article Category: Research Article

Publicado en línea: 31 jul 2023

Páginas: 170 - 177

Recibido: 22 oct 2022

Aceptado: 21 jul 2023

DOI: https://doi.org/10.2478/jccm-2023-0021

Palabras claveCOVID-19, weaning, risk factors, shock, COPD, SOFA score, ARDS

© 2023 Effrosyni Gerovasileiou et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Palabras clave
COVID-19, weaning, risk factors, shock, COPD, SOFA score, ARDS