<abstract xmlns="http://www.w3.org/1999/xhtml">The effect of aqueous matured stem extract of <italic>Opuntia dillenii</italic> on selected biochemical parameters in Male Wistar rats was explored. Standard analytical methods were applied. Forty Wistar rats (80-100g) were used in the animal studies, separated into four groups. The control group was solely administered normal feed and saline, group I was administered 100mgkg−1 of the extract, group II received 300mgkg−1 of the extract and group III received 500 mg/kg−1 of the extract. A significant increase (p&lt;0.05) in the activities of alanine aminotransferase (ALT) and alkaline phosphatase was observed in group II and III rats, as compared with the controls. A significant decrease in urea and creatinine concentrations was found only in group III rats against the controls. Also, a significant (p&lt;0.05) decrease in triglyceride, total cholesterol, and low density lipoprotein (LDL)-cholesterol was seen in group II and group III rats when compared with the control. The hematological evaluation revealed a significant (p&lt;0.05) decrease in red blood cell and hemoglobin levels in group III rats when compared with the control. The findings showed both beneficial and toxicological effects of the plant. Hence, for optimal therapeutic benefits, a further toxicological survey could still be carried out perhaps at higher doses.</abstract>

The effect of aqueous matured stem extract of Opuntia dillenii on selected biochemical parameters in Male Wistar rats was explored. Standard analytical methods were applied. Forty Wistar rats (80-100g) were used in the animal studies, separated into four groups. The control group was solely administered normal feed and saline, group I was administered 100mgkg−1 of the extract, group II received 300mgkg−1 of the extract and group III received 500 mg/kg−1 of the extract. A significant increase (p<0.05) in the activities of alanine aminotransferase (ALT) and alkaline phosphatase was observed in group II and III rats, as compared with the controls. A significant decrease in urea and creatinine concentrations was found only in group III rats against the controls. Also, a significant (p<0.05) decrease in triglyceride, total cholesterol, and low density lipoprotein (LDL)-cholesterol was seen in group II and group III rats when compared with the control. The hematological evaluation revealed a significant (p<0.05) decrease in red blood cell and hemoglobin levels in group III rats when compared with the control. The findings showed both beneficial and toxicological effects of the plant. Hence, for optimal therapeutic benefits, a further toxicological survey could still be carried out perhaps at higher doses.

Biochemical Effects of Matured Stem Extract of <italic>Opuntia Dillenii</italic> in Male Wistar Rats

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Biochemical Effects of Matured Stem Extract of  in Male Wistar Rats

The effect of aqueous matured stem extract of Opuntia dillenii on selected biochemical parameters in Male Wistar rats was explored. Standard analytical methods...

Biochemical Effects of Matured Stem Extract of Opuntia Dillenii in Male Wistar Rats

Publicado en línea: 30 dic 2019

Páginas: 49 - 58

Recibido: 01 feb 2018

Aceptado: 26 jun 2018

DOI: https://doi.org/10.2478/jbcr-2018-0008

Palabras clave
biochemical parameters, toxicity, hemoglobin, lipid profile

© 2018 Uche C. Njoku et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Biochemical Effects of Matured Stem Extract of Opuntia Dillenii in Male Wistar Rats

Publicado en línea: 30 dic 2019

Páginas: 49 - 58

Recibido: 01 feb 2018

Aceptado: 26 jun 2018

DOI: https://doi.org/10.2478/jbcr-2018-0008

Palabras clavebiochemical parameters, toxicity, hemoglobin, lipid profile

© 2018 Uche C. Njoku et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
biochemical parameters, toxicity, hemoglobin, lipid profile