Acceso abierto

Hepatoprotective effects of quercetin against natural and chemical toxicities: A review

, , ,  y   
27 ene 2025

Cite
Descargar portada

Abarikwu SO. (2014). Protective effect of quercetin on atrazine-induced oxidative stress in the liver, kidney, brain, and heart of adult wistar rats. Toxicol Int 21: 148–155. Search in Google Scholar

Abdel-Wahhab MA, Ahmed HH, Hagazi MM. (2006). Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts. J Appl Toxicol 26: 229–238. Search in Google Scholar

Abdel-Wahhab MA, Aljawish A, El-Nekeety AA, Abdel-Aiezm SH, Abdel-Kader HAM, Rihn BH, Joubert O. (2015). Chitosan nanoparticles and quercetin modulate gene expression and prevent the genotoxicity of aflatoxin B(1) in rat liver. Toxicol Rep 2: 737–747. Search in Google Scholar

Abdelhalim MAK, Moussa SAA, Qaid HAY. (2018). The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats. Int J Nanomedicine 13: 2821–2825. Search in Google Scholar

Abo-Salem OM, Abd-Ellah MF, Ghonaim MM. (2011). Hepatoprotective activity of quercetin against acrylonitrile-induced hepatotoxicity in rats. J Biochem Mol Toxicol 25: 386–392. Search in Google Scholar

Adewusi E, Afolayan AJ. (2010). A review of natural products with hepatoprotective activity. J. Med. Plant Res. 4: 1318–1334. Search in Google Scholar

Afifi NA, Ibrahim MA, Galal MK. (2018). Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. Can J Physiol Pharmacol 96: 624–629. Search in Google Scholar

Ahmed OA, Badr-Eldin SM, Tawfik MK, Ahmed TA, El-Say KM, Badr JM. (2014). Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity. J. Pharm. Sci. 103: 602–612. Search in Google Scholar

Akinmoladun AC, Oladejo CO, Josiah SS, Famusiwa CD, Ojo OB, Olaleye MT. (2018). Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity? Pathophysiology 25: 365–371. Search in Google Scholar

Al-Asmari AK, Khan HA, Manthiri RA, Al-Khlaiwi AA, Al-Asmari BA, Ibrahim KE. (2018). Protective effects of a natural herbal compound quercetin against snake venom-induced hepatic and renal toxicities in rats. Food Chem. Toxicol. 118: 105–110. Search in Google Scholar

Al Asmari A, Manthiri RA, Khan HA. (2014). Identification and phylogeny of Arabian snakes: Comparison of venom chromatographic profiles versus 16S rRNA gene sequences. Saudi J Biol Sci 21: 436–441. Search in Google Scholar

Ali N, Rashid S, Nafees S, Hasan SK, Shahid A, Majed F, Sultana S. (2017). Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chem.-Biol. Interact. 272: 80–91. Search in Google Scholar

Ansar S, Siddiqi NJ, Zargar S, Ganaie MA, Abudawood M. (2016). Hepatoprotective effect of Quercetin supplementation against Acrylamide-induced DNA damage in wistar rats. BMC COMPLEM ALTERN M 16: 327. Search in Google Scholar

Arafa A, Ghanem H, Soliman M, EL-Meligy E. (2017). Modulation effects of quercetin against copper oxide nanoparticles-induced liver toxicity in rats. Egypt Pharmaceut J 16: 78–86. Search in Google Scholar

Ashkani-Esfahani S, Bagheri F, Azarpira N, Esmaeilzadeh E, Emami Y, Hassanabadi N, Keshtkar M. (2016). Protective effects of quercetin on thioacet-amide-induced acute liver damage and its related biochemical and pathological alterations. Egypt J Hosp Med 28: 123–127. Search in Google Scholar

Baky N, Faddah L, Al-Rasheed NM, Al-Rasheed NM, Shebali W. (2013). Role of quercetin and L-arginine in alleviating zinc oxide nanoparticle hepatotoxicity in rats. CHIANG MAI J SCI 40: 577–592. Search in Google Scholar

Balandrin M, Klocke J, Wurtele E, Bollinger W. (1985). Natural plant chemicals: sources of industrial and medicinal materials. Science 228: 1154–1160. Search in Google Scholar

Barman PK, Mukherjee R, Prusty BK, Suklabaidya S, Senapati S, Ravindran B. (2016). Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice. Cell Death Dis 7: e2224. Search in Google Scholar

Barros PP, Silva GHd, Gonçalves GMS, Oliveira JC, Pagnan LG, Arco-e-Flexa L. (2017). Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats. Braz Arch Biol Technol 60: e17160138. Search in Google Scholar

Bell JRH, Hye RJ, Miyai K. (1984). Streptozotocin-induced liver tumors in the Syrian hamster. Carcinogenesis 5: 1235–1238. Search in Google Scholar

Bodaghi-Namileh V, Sepand MR, Omidi A, Aghsami M, Seyednejad SA, Kasirzadeh S, Sabzevari O. (2018). Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats. Environ Toxicol Pharmacol 58: 11–20. Search in Google Scholar

Buha A, Antonijević B, Milovanović V, Janković S, Bulat Z, Matović V. (2015). Polychlorinated biphenyls as oxidative stress inducers in liver of subacutely exposed rats: Implication for dose-dependence toxicity and benchmark dose concept. Environ Res 136: 309–317. Search in Google Scholar

Casalino E, Calzaretti G, Sblano C, Landriscina C. (2002). Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology 179: 37–50. Search in Google Scholar

Chattopadhyay RR. (2003). Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II. J Ethnopharmacol 89: 217–219. Chen M, Carmella SG, Sipe C, Jensen J, Luo X, Le CT, Murphy SE, Benowitz NL, Search in Google Scholar

McClernon FJ, Vandrey R, Allen SS, Denlinger-Apte R, Cinciripini PM, Strasser AA, al’Absi M, Robinson JD, Donny EC, Hatsukami D, Hecht SS. (2019). Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein. PLOS ONE 14: e0210104. Search in Google Scholar

Chen S, Jiang H, Wu X, Fang J. (2016). Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes. Mediators Inflamm 2016: 9340637–9340637. Search in Google Scholar

Chen X. (2010). Protective effects of quercetin on liver injury induced by ethanol. Pharmacogn Mag 6: 135–141. Search in Google Scholar

Chen YW, Chou HC, Lin ST, Chen YH, Chang YJ, Chen L, Chan HL. (2013). Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury. J Evid Based Complementary Altern Med 2013: 364519–364535. Search in Google Scholar

Cui Y, Han Y, Yang X, Sun Y, Zhao Y. (2013). Protective effects of quercetin and quercetin-5’,8-disulfonate against carbon tetrachloride-caused oxidative liver injury in mice. Molecules 19: 291–305. Search in Google Scholar

D’Andrea G. (2015). Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia 106: 256–271. Search in Google Scholar

David AVA, Satyanarayana N, Parasuraman S, Bharathi S, Arulmoli R. (2016). Ameliorative effect of quercetin on methotrexate induced toxicity in sprague-dawley rats: A histopathological study. INDIAN J PHARM EDUC 2016: S200–S208. Search in Google Scholar

Dias AS, Porawski M, Alonso M, Marroni N, Collado PS, Gonzalez-Gallego J. (2005). Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nutr 135: 2299–2304. Search in Google Scholar

Djurasevic S, Bojic S, Nikolic B, Dimkic I, Todorovic Z, Djordjevic J, Mitic-Culafic D. (2018). Beneficial Effect of Virgin Coconut Oil on Alloxan-Induced Diabetes and Microbiota Composition in Rats. Plant Foods Hum Nutr 73: 295–301. Search in Google Scholar

Domitrovic R, Jakovac H, Vasiljev Marchesi V, Vladimir-Knezevic S, Cvijanovic O, Tadic Z, Romic Z, Rahelic D. (2012). Differential hepatoprotective mechanisms of rutin and quercetin in CCl(4)-intoxicated BALB/cN mice. Acta Pharmacol Sin 33: 1260–1270. Search in Google Scholar

Dorri M, Hashemitabar S, Hosseinzadeh H. (2018). Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol 41: 338–351. Search in Google Scholar

Eftekhari A, Ahmadian E, Panahi-Azar V, Hosseini H, Tabibiazar M, Maleki Dizaj S. (2018). Hepatoprotective and free radical scavenging actions of quercetin nanoparticles on aflatoxin B1-induced liver damage: in vitro/in vivo studies. Artif Cells Nanomed Biotechnol 46: 411–420. Search in Google Scholar

El-Denshary ES, Aljawish A, El-Nekeety AA, Hassan NS, Saleh RH, Rihn BH, Abdel-Wahhab MA. (2015). Possible synergistic effect and antioxidant properties of chitosan nanoparticles and quercetin against carbon tetrachloride-induce hepatotoxicity in rats. Soft Nanoscience Letters 5: 36–51. Search in Google Scholar

El-Nekeety AA, Abdel-Azeim SH, Hassan AM, Hassan NS, Aly SE, Abdel-Wahhab MA. (2014). Quercetin inhibits the cytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet. Toxicol Rep 1: 319–329. Search in Google Scholar

El-Nekeety AA, Abdel-Azeim SH, Hassan AM, Hassan NS, Aly SE, Abdel-Wahhab MA. (2014). Quercetin inhibits the cytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet. Toxicology reports 1: 319–329. Search in Google Scholar

El Faras A, Elsawaf A. (2017). Hepatoprotective activity of quercetin against paracetamol-induced liver toxicity in rats. Tanta Med J 45: 92–98. Search in Google Scholar

El Gohary OA, Shoman AA, A ST. (2013). Protective effect of Quercetin on liver damage in Streptozotocin-induced Diabetic Rats. Search in Google Scholar

Eldin OS, Bakry S, Shaeir WAA, Mohammed MS, Abd-Alzaher OFA. (2015). Possible hepatoprotective effect of quercetin against 2-butoxyethanol induced hepatic damage in rats. Middle East J Sci Res 23: 2173–2182. Search in Google Scholar

Fanoudi S, Alavi MS, Karimi G, Hosseinzadeh H. (2018). Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol: 1–15. Search in Google Scholar

Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G. (1995). Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21: 190–198. Search in Google Scholar

Ghosh A, Mandal AK, Sarkar S, Das N. (2011). Hepatoprotective and neuro-protective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats. Drug Deliv 18: 451–459. Search in Google Scholar

Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. (2009). Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci. 84: 75–80. Search in Google Scholar

Gomes IBS, Porto ML, Santos MCLFS, Campagnaro BP, Pereira TMC, Meyrelles SS, Vasquez EC. (2014). Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy. LIPIDS HEALTH DIS 13: 184–184. Search in Google Scholar

Gonzalez O, Fontanes V, Raychaudhuri S, Loo R, Loo J, Arumugaswami V, Sun R, Dasgupta A, French SW. (2009). The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology 50: 1756–1764. Gupta S. (1994). Prospects and perspectives of natural plants products in medicine. Indian J Pharmacol 26: 1–12. Search in Google Scholar

Hashemzaei M, Delarami Far A, Yari A, Heravi RE, Tabrizian K, Taghdisi SM, et al. (2017). Anticancer and apoptosisinducing effects of quercetin in vitro and in vivo. Oncol Rep 38: 819–828. Search in Google Scholar

Hedayati N, Naeini MB, Nezami A, Hosseinzadeh H, Wallace Hayes A, Hosseini S, Imenshahidi M, Karimi G. (2019). Protective effect of lycopene against chemical and natural toxins: A review. Biofactors 45(1): 5–23. Search in Google Scholar

Hernandez-Ortega LD, Alcantar-Diaz BE, Ruiz-Corro LA, Sandoval-Rodriguez A, Bueno-Topete M, Armendariz-Borunda J, Salazar-Montes AM. (2012). Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance. J Gastroenterol Hepatol 27: 1865–1872. Search in Google Scholar

Hogervorst JGF, van den Brandt PA, Godschalk RWL, van Schooten F-J, Schouten LJ. (2016). The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk. Sci Rep 6: 34902. Search in Google Scholar

Hosseinzadeh H, Tabeshpur J, Mehri S. (2014). Effect of Saffron extract on Acrylamide-induced toxicity: In vitro and in vivo assessment. Chin J Integr Med Search in Google Scholar

Huan SK, Wang KT, Lee CJ, Sung CH, Chien TY, Wang CC. (2012). Wu-Chia-Pi solution attenuates carbon tetrachloride-induced hepatic injury through the antioxidative abilities of its components acteoside and quercetin. Molecules 17: 14673–14684. Search in Google Scholar

Hung PC, Cheng SF, Liou SH, Tsai SW. (2011). Biological monitoring of low-level 2-butoxyethanol exposure in decal transfer workers in bicycle manufacturing factories. Occup Environ Med 68: 777–782. Search in Google Scholar

Iranshahy M, Iranshahi M, Abtahi SR, Karimi G. (2018). The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review. Food Chem Toxicol 120: 261–276. Search in Google Scholar

Janbaz KH, Saeed SA, Gilani AH. (2004). Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. Phytomedicine 11: 424–430. Search in Google Scholar

Jie Q, Tang Y, Deng Y, Li Y, Shi Y, Gao C, Xing M, Wang D, Liu L, Yao P. (2013). Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes. Alcohol 47: 141–148. Search in Google Scholar

Jin Y, Huang ZL, Li L, Yang Y, Wang CH, Wang ZT, Ji LL. (2019). Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway. Acta Pharmacol. Sin. 40: 75–85. Search in Google Scholar

Kalantari H, Foruozandeh H, Khodayar MJ, Siahpoosh A, Saki N, Kheradmand P. (2018). Antioxidant and hepatoprotective effects of Capparis spinosa L. fractions and Quercetin on tert-butyl hydroperoxide- induced acute liver damage in mice. J Tradit Complement Med 8: 120–127. Search in Google Scholar

Kang HJ, Pichiah PBT, Abinaya RV, Sohn HS, Cha YS. (2016). Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet. Food Sci. Biotechnol. 25: 855–860. Search in Google Scholar

Kaplowitz N. (2005). Idiosyncratic drug hepatotoxicity. Nat. Rev. Drug Discov. 4: 489. Search in Google Scholar

Kebieche M, Lakroun Z, Lahouel M, Bouayed J, Meraihi Z, Soulimani R. (2009). Evaluation of epirubicin-induced acute oxidative stress toxicity in rat liver cells and mitochondria, and the prevention of toxicity through quercetin administration. Exp Toxicol Pathol 61: 161–167. Search in Google Scholar

Keerthi M, Lashkmi P, Santhosh A, Rama R. (2014). Review on Polyphenols as nature gift. WJPPS 3: 445–455. Search in Google Scholar

Kemelo MK, Pierzynová A, Kutinová Canová N, Kučera T, Farghali H. (2017). The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats. Chem.-Biol. Interact. 269: 1–8. Search in Google Scholar

Khan AG, Whidby J, Miller MT, Scarborough H, Zatorski AV, Cygan A, et al. (2014). Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2. Nature 509: 381–384. Search in Google Scholar

Kim EY, Hong K-B, Suh HJ, Choi H-S. (2015). Protective effects of germinated and fermented soybean extract against tert-butyl hydroperoxide-induced hepatotoxicity in HepG2 cells and in rats. Food Funct 6: 3512–3521. Search in Google Scholar

Krishnappa P, Venkatarangaiah K, Venkatesh, Shivamogga Rajanna SK, Kashi Prakash Gupta R. (2014). Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Biomed Res Int 2014: 507851–507865. Search in Google Scholar

Lee ES, Lee HE, Shin JY, Yoon S, Moon JO. (2003). The flavonoid quercetin inhibits dimethylnitrosamine-induced liver damage in rats. J. Pharm. Pharmacol. 55: 1169–1174. Search in Google Scholar

Lee YJ, Beak SY, Choi I, Sung JS. (2018). Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1. Food sci biotech 27: 809–817. Search in Google Scholar

Li J, Lu Y, Xiao C, Lu C, Niu X, He X, Zhao H, Tan Y, Lu A. (2011). Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. J Ethnopharmacol 135: 270–277. Search in Google Scholar

Li X, Liu HC, Yao QY, Xu BL, Zhang SC, Tu CT. (2016). Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway. Inflammation 39: 96–106. Search in Google Scholar

Li Y, Chen M, Xu Y, Yu X, Xiong T, Du M, Sun J, Liu L, Tang Y, Yao P. (2016). Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxid Med Cell Longev 2016: 1–15. Search in Google Scholar

Li Y, Deng Y, Tang Y, Yu H, Gao C, Liu L, Liu L, Yao P. (2014). Quercetin protects rat hepatocytes from oxidative damage induced by ethanol and iron by maintaining intercellular liable iron pool. Hum Exp Toxicol 33: 534–541. Search in Google Scholar

Liu CM, Ma JQ, Xie WR, Liu SS, Feng ZJ, Zheng GH, Wang AM. (2015). Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway. Food Chem Toxicol 82: 19–26. Search in Google Scholar

Liu S, Hou W, Yao P, Li N, Zhang B, Hao L, Nüssler AK, Liu L. (2012). Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage. Toxicol In Vitro 26: 74–80. Search in Google Scholar

Ma J-Q, Li Z, Xie W-R, Liu C-M, Liu S-S. (2015). Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway. Int. Immunopharmacol. 28: 531–539. Search in Google Scholar

Madrigal-Santillán E, Madrigal-Bujaidar E, Álvarez-González I, Sumaya-Martínez MT, Gutiérrez-Salinas J, Bautista M, Morales-Gonzáleza, García-Luna y González-Rubio M, Aguilar-Faisal JL, Morales-González JA. (2014). Review of natural products with hepatoprotective effects. World J Gastroenterol 20: 14787–14804. Search in Google Scholar

Mahmoudi A, Ghorbel H, bouallegui Z, Marrekchi R, Isoda H, Sayadi S. (2015). Oleuropein and hydroxytyrosol protect from bisphenol A effects in livers and kidneys of lactating mother rats and their pups’. Exp Toxicol Pathol 67: 413–425. Search in Google Scholar

Mehta A, Kaur G, Chintamaneni M. (2012). Piperine and quercetin enhances antioxidant and hepatoprotective effect of curcumin in paracetamol induced oxidative stress. INT J PHARMACOL 8: 101–107. Search in Google Scholar

Mezera V, Endlicher R, Kucera O, Sobotka O, Drahota Z, Cervinkova Z. (2016). Effects of Epigallocatechin Gallate on Tert-Butyl Hydroperoxide-Induced Mitochondrial Dysfunction in Rat Liver Mitochondria and Hepatocytes. Oxid Med Cell Longev 2016: 1–8. Search in Google Scholar

Milton Prabu S, Shagirtha K, Renugadevi J. (2010). Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats. Eur Rev Med Pharmacol Sci 14: 903–914. Search in Google Scholar

Miltonprabu S, Tomczyk M, Skalicka-Wozniak K, Rastrelli L, Daglia M, Nabavi SF, Alavian sm, Nabavi SM. (2017). Hepatoprotective effect of quercetin: From chemistry to medicine. Food Chem Toxicol 108: 365–374. Search in Google Scholar

Mukherjee AK, Maity CR. (1997). Effect of dietary supplementation of vitamin E in partial inhibition of Russell’s viper venom phospholipase A2 induced hepatocellular and microsomal membrane damage in rats. Acta Physiol Hung 85: 367–374. Search in Google Scholar

No H-N, Kwon H, Park Y-G, Cheon C-I, Park J-S, Park T, Aruoma OI, Sung M-K. (2007). Dietary quercetin inhibits 1,2-dimethylhydrazine–induced liver DNA damage without altering colon DNA damage or precancerous lesion formation in rats. Nutr Res 27: 659–664. Search in Google Scholar

Osbourn AE, Lanzotti V. (2009). Plant-derived natural products. New York: Springer. Search in Google Scholar

Padma VV, Baskaran R, Roopesh RS, Poornima P. (2012). Quercetin attenuates lindane induced oxidative stress in Wistar rats. Mol. Biol. Rep. 39: 6895–6905. Search in Google Scholar

Pan T-L, Wang P-W, Huang C-H, Leu Y-L, Wu T-H, Wu Y-R, You J-S. (2015). Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model. Sci Rep 5: 11734. Search in Google Scholar

Pavanato A, Tunon MJ, Sanchez-Campos S, Marroni CA, Llesuy S, Gonzalez-Gallego J, Marroni N. (2003). Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. Dig Dis Sci 48: 824–829. Search in Google Scholar

Peng Z, Gong X, Yang Y, Huang L, Zhang Q, Zhang P, Wan R, Zhang B. (2017). Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-kappaB and MAPK signal pathways. Int. Immunopharmacol. 52: 281–289. Search in Google Scholar

Pilkhwal S, Tirkey N, Kuhad A, Chopra K. (2010). Effect of Bioflavonoid Quercetin on Endotoxin-Induced Hepatotoxicity and Oxidative Stress in Rat Liver. IJPT 9: 40–47. Search in Google Scholar

Punvittayagul C, Chariyakornkul A, Chewonarin T, Jarukamjorn K, Wong-poomchai R. (2018). Augmentation of diethylnitrosamine–induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine. Drug Chem Toxicol: 1–8. Search in Google Scholar

Renugadevi J, Prabu SM. (2009). Ameliorative effect of quercetin against cadmium induced toxicity in liver of Wistar rats. CELL TISSUE RES 9: 1665. Search in Google Scholar

Sajid M, Khan MR, Shah NA, Shah SA, Ismail H, Younis T, Zahra Z. (2016). Phytochemical, antioxidant and hepatoprotective effects of Alnus nitida bark in carbon tetrachloride challenged Sprague Dawley rats. BMC Complement Altern Med 16: 268. Search in Google Scholar

Salama SM, Abdulla MA, AlRashdi AS, Ismail S, Alkiyumi SS, Golbabapour S. (2013). Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complement Altern Med 13: 56. Search in Google Scholar

Sangai NP, Verma RJ. (2012). Quercetin ameliorates bisphenol A-induced toxicity in mice. Acta Pol Pharm 69: 557–563. Search in Google Scholar

Sasu A, Herman H, Folk A, Baltă C, Roșu M, Miuțescu E, Hermenean A, Cotoraci C. (2016). Protective Effects Of Silymarin On Epirubicin-Induced Hepatotoxicity In Mice. STUD UNIV VASILE GOLDIS ARAD SER STIINT VIETII 26: 305–316. Search in Google Scholar

Schiano TD. (2003). Hepatotoxicity and complementary and alternative medicines. Clin Liver Dis 7: 453–473. Search in Google Scholar

Sekaran S, Kandaswamy S, Gunasekaran K, Perumal E, Afsar Basha FY, Madhan Mohan BJ, Jagadeesan A. (2012). Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. J Biochem Mol Toxicol 26: 522–532. Search in Google Scholar

Shaji J, Iyer S. (2012). Novel double loaded Quercetin liposomes: Evidence of superior therapeutic potency against CCl4 induced hepatotoxicity–A comparative study. Asian J Pharm Clin Res 5: 104–108. Search in Google Scholar

Shepard CW, Finelli L, Alter MJ. (2005). Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5: 558–567. Search in Google Scholar

Sirovina D, Orsolic N, Koncic MZ, Kovacevic G, Benkovic V, Gregorovic G. (2013). Quercetin vs chrysin: effect on liver histopathology in diabetic mice. Hum Exp Toxicol 32: 1058–1066. Search in Google Scholar

Somade OT, Olorode SK, Olaniyan TO, Faokunla O. (2016). Quercetin, a polyphenolic phytochemical prevents sodium azide-induced extra-hepatic oxidative stress in rats. Cogent Biol 2: 1200798. Search in Google Scholar

Srivastava S, Somasagara RR, Hegde M, Nishana M, Tadi SK, Srivastava M, Choudhary B, Raghavan SC. (2016). Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis. Sci Rep 6: 24049. Search in Google Scholar

Startek JB, Talavera K, Voets T, Alpizar YA. (2018). Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation. Sci Rep 8: 12010. Search in Google Scholar

Tabeshpour J, Mehri S, Shaebani Behbahani F, Hosseinzadeh H. (2018). Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review. Phytother Res 32: 2164–2190. Search in Google Scholar

Taghizadeh SF, Rezaee R, Davarynejad G, Asili J, Nemati SH, Goumenou M, Tsakiris I, Tsatsakis AM, Shirani K, Karimi G. (2018). Risk assessment of exposure to aflatoxin B1 and ochratoxin A through consumption of different Pistachio (Pistacia vera L.) cultivars collected from four geographical regions of Iran. Environ Toxicol Pharmacol 61: 61–66. Search in Google Scholar

Tang Y, Tian H, Shi Y, Gao C, Xing M, Yang W, Bao W, Wang D, Liu L, Yao P. (2013). Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO. Phytomedicine 20: 699–704. Trefts E, Gannon M, Wasserman DH. (2017). The liver. Curr Biol 27: R1147–R1151. Search in Google Scholar

Tzankova V, Aluani D, Kondeva-Burdina M, Yordanov Y, Odzhakov F, Apostolov A, Yoncheva K. (2017). Hepatoprotective and antioxidant activity of quercetin loaded chitosan/alginate particles in vitro and in vivo in a model of paracetamol-induced toxicity. Biomed Pharmacother 92: 569–579. Search in Google Scholar

Valcheva-Kuzmanova S. (2015). Comparative Study Of The Protective Effect Of Aronia Melanocarpa Fruit Juice And Quercetin In A Model Of Paracetamol-Induced Hepatotoxicity In Rats. JBCR 8: 118–123. Search in Google Scholar

Verma PK, Raina R, Prawez S, Sultana M, Singh M, Kumar P. (2018). Protective Mechanisms of Quercetin on Cisplatin Induced Oxidative Damage in Hepatic Tissue of Wistar Rats. Proc Natl Acad Sci India Sect B Biol Sci 88: 1399–1407. Search in Google Scholar

Vijayakumar K, Rengarajan R, Radhakrishnan R, Mathew S, Qadri I, Anand AV. (2018). Psidium guajava Leaf Extracts and Their Quercetin Protect HepG2 Cell Lines Against CCL 4 Induced Cytotoxicity. IJCB: 1–6. Search in Google Scholar

VoPham T, Bertrand KA, Hart JE, Laden F, Brooks MM, Yuan J-M, Talbott EO, Chang C-CH, Weissfeld JL. (2017). Pesticide exposure and liver cancer: a review. Cancer Causes Control 28: 177–190. Search in Google Scholar

Wang J, Miao M, Zhang Y, Liu R, Li X, Cui Y, Qu L. (2015). Quercetin ameliorates liver injury induced with Tripterygium glycosides by reducing oxidative stress and inflammation. Can J Physiol Pharmacol 93: 427–433. Search in Google Scholar

Wei C, Zhou L, Zhang Y, Zhang J, Zhang Q, Tao K. (2017). [Protective effect of quercetin against immunological liver injury through activating Nrf2/ARE signaling pathway]. Chinese journal of cellular and molecular immunology 33: 300–304. Search in Google Scholar

Wei CB, Tao K, Jiang R, Zhou LD, Zhang QH, Yuan CS. (2017). Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-kappaB pathway. Int. Immunopharmacol. 53: 73–82. Search in Google Scholar

Williams AO. (1967). Studies on azide, caeruloplasmin and copper in relation to Wilson’s disease. Br. J. Exp. Pathol. 48: 180–187. Search in Google Scholar

Williams JA, Manley S, Ding WX. (2014). New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. World J Gastroenterol 20: 12908–12933. Search in Google Scholar

Wu L, Wang C, Li J, Li S, Feng J, Liu T, Xu S, Wang W, Lu X, Chen K, Xia Y, Fan X, Guo C. (2017). Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis. Biomed Pharmacother 96: 1137–1146. Search in Google Scholar

Xie W, Wang M, Chen C, Zhang X, Melzig MF. (2016). Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury. Life Sci J 152: 180–189. Search in Google Scholar

Xue H, Xie W, Jiang Z, Wang M, Wang J, Zhao H, Zhang X. (2016). 3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2. Xenobiotica 46: 931–939. Search in Google Scholar

Yousef MI, Omar SA, El-Guendi MI, Abdelmegid LA. (2010). Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol 48: 3246–3261. Search in Google Scholar

Yu N, Wei S, Li M, Yang J, Li K, Jin L, Xie Y, Giesy JP, Zhang X, Yu H. (2016). Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach. Sci Rep 6: 23963. Search in Google Scholar

Yüce A, Ateşşahin A, Çeribaşı AO, Aksakal M. (2007). Ellagic Acid Prevents Cisplatin-Induced Oxidative Stress in Liver and Heart Tissue of Rats. Basic Clin Pharmacol Toxicol 101: 345–349. Search in Google Scholar

Zargar S, Siddiqi NJ, Al Daihan SK, Wani TA. (2015). Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver. Acta Biochim Pol 62: 207–213. Search in Google Scholar

Zeng H, Guo X, Zhou F, Xiao L, Liu J, Jiang C, Xing M, Yao P. (2019). Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy. Food Chem Toxicol 125: 21–28. Search in Google Scholar

Zhang J-q, Shi L, Xu X-n, Huang S-c, Lu B, Ji L-l, Wang Z-t. (2014). Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism. J Zhejiang Univ Sci B 15: 1039–1047. Search in Google Scholar

Zhang K, Zhang M, Liu Z, Zhang Y, Gu L, Hu G, Chen X, Jia J. (2016). Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats. Fitoterapia 113: 102–109. Search in Google Scholar

Zou H, Zheng Y-f, Ge W, Wang S-b, Mou X-z. (2018). Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma. Sci Rep 8: 2182. Search in Google Scholar

Zou W, Liu W, Yang B, Wu L, Yang J, Zou T, Liu F, Xia L, Zhang D. (2015). Quercetin protects against perfluorooctanoic acid-induced liver injury by attenuating oxidative stress and inflammatory response in mice. Int. Immunopharmacol. 28: 129–135. Search in Google Scholar

Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicina, Medicina Clínica, Farmacología, toxicología