This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Arena C, De Micco V, Macaeva E, Quintens R (2014) Space radiation effects on plant and mammalian cells. Acta Astronautica104: 419–431ArenaCDe MiccoVMacaevaEQuintensR2014Space radiation effects on plant and mammalian cells10441943110.1016/j.actaastro.2014.05.005Search in Google Scholar
Ave M, Boyle P, Brannon E, Gahbauer F, Hermann G, Höppner C, Hörandel J, Ichimura M, Müller D, Obermeier A (2011) The TRACER instrument: A balloon-borne cosmic-ray detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment654: 140–156AveMBoylePBrannonEGahbauerFHermannGHöppnerCHörandelJIchimuraMMüllerDObermeierA2011The TRACER instrument: A balloon-borne cosmic-ray detector65414015610.1016/j.nima.2011.05.050Search in Google Scholar
Badhwar GD, O’Neill PM (1992) An improved model of galactic cosmic-radiation for space exploration missions. Nuclear Tracks and Radiation Measurements20: 403–410BadhwarGDO’NeillPM1992An improved model of galactic cosmic-radiation for space exploration missions2040341010.1016/1359-0189(92)90024-PSearch in Google Scholar
Benton E (2012) Space radiation passive dosimetry. The Health Risks of Extraterrestrial Environmentshttps://three.jsc.nasa.gov/articles/BentonPassive-Dosimetry.pdfBentonE2012Space radiation passive dosimetryhttps://three.jsc.nasa.gov/articles/BentonPassive-Dosimetry.pdfSearch in Google Scholar
Benton ER, Benton EV (2001) Space radiation dosimetry in low-Earth orbit and beyond. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms184: 255–294BentonERBentonEV2001Space radiation dosimetry in low-Earth orbit and beyond18425529410.1016/S0168-583X(01)00748-0Search in Google Scholar
Berardini TZ, Reiser L, Li D, Mezheritsky Y, Muller R, Strait E, Huala E (2015) The Arabidopsis information resource: Making and mining the “gold standard” annotated reference plant genome. Genesis53: 474–485BerardiniTZReiserLLiDMezheritskyYMullerRStraitEHualaE2015The Arabidopsis information resource: Making and mining the “gold standard” annotated reference plant genome5347448510.1002/dvg.22877Search in Google Scholar
Cartwright BG, Shirk EK, Price PB (1978) A nuclear-track-recording polymer of unique sensitivity and resolution. Nuclear Instruments and Methods153: 457–460CartwrightBGShirkEKPricePB1978A nuclear-track-recording polymer of unique sensitivity and resolution15345746010.1016/0029-554X(78)90989-8Search in Google Scholar
Chin C-S, Peluso P, Sedlazeck FJ, Nattestad M, Concepcion GT, Clum A, Dunn C, O’Malley R, Figueroa-Balderas R, Morales-Cruz A, Cramer GR, Delledonne M, Luo C, Ecker JR, Cantu D, Rank DR, Schatz MC (2016) Phased diploid genome assembly with single-molecule real-time sequencing. Nature Methods13: 1050ChinC-SPelusoPSedlazeckFJNattestadMConcepcionGTClumADunnCO’MalleyRFigueroa-BalderasRMorales-CruzACramerGRDelledonneMLuoCEckerJRCantuDRankDRSchatzMC2016Phased diploid genome assembly with single-molecule real-time sequencing13105010.1038/nmeth.4035550314427749838Search in Google Scholar
De Micco V, Arena C, Pignalosa D, Durante M (2011) Effects of sparsely and densely ionizing radiation on plants. Radiation and Environmental Biophysics50: 1–19De MiccoVArenaCPignalosaDDuranteM2011Effects of sparsely and densely ionizing radiation on plants5011910.1007/s00411-010-0343-821113610Search in Google Scholar
Durante M (2014) Space radiation protection: Destination Mars. Life Sciences in Space Research1: 2–9DuranteM2014Space radiation protection: Destination Mars12910.1016/j.lssr.2014.01.00226432587Search in Google Scholar
Feng S, Cokus SJ, Schubert V, Zhai J, Pellegrini M, Jacobsen SE (2014) Genome-wide Hi-C analyses in wild-type and mutants reveal high-resolution chromatin interactions in Arabidopsis. Molecular Cell55: 694–707FengSCokusSJSchubertVZhaiJPellegriniMJacobsenSE2014Genome-wide Hi-C analyses in wild-type and mutants reveal high-resolution chromatin interactions in Arabidopsis5569470710.1016/j.molcel.2014.07.008434790325132175Search in Google Scholar
Gangappa SN, Botto JF (2016) The multifaceted roles of HY5 in plant growth and development. Molecular Plant9: 1353–1365GangappaSNBottoJF2016The multifaceted roles of HY5 in plant growth and development91353136510.1016/j.molp.2016.07.002Search in Google Scholar
Griffith PM, Raley C, Sun D, Zhao Y, Sun Z, Mehta M, Tran B, Wu X (2018) PacBio library preparation using blunt-end adapter ligation produces significant artefactual fusion DNA sequences. bioRxivGriffithPMRaleyCSunDZhaoYSunZMehtaMTranBWuX2018PacBio library preparation using blunt-end adapter ligation produces significant artefactual fusion DNA sequences10.1101/245241Search in Google Scholar
Hada M, Zhang Y, Feiveson A, Cucinotta FA, Wu H (2011) Association of inter- and intrachromosomal exchanges with the distribution of low- and high-LET radiation-induced breaks in chromosomes. Radiation Research176: 25–37HadaMZhangYFeivesonACucinottaFAWuH2011Association of inter- and intrachromosomal exchanges with the distribution of low- and high-LET radiation-induced breaks in chromosomes176253710.1667/RR2433.1Search in Google Scholar
Huefner ND, Yoshiyama K, Friesner JD, Conklin PA, Britt AB (2014) Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana. Frontiers in Plant Science5: 206HuefnerNDYoshiyamaKFriesnerJDConklinPABrittAB2014Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana520610.3389/fpls.2014.00206Search in Google Scholar
Kavanagh JN, Redmond KM, Schettino G, Prise KM (2013) DNA double strand break repair: a radiation perspective. Antioxidants & Redox Signaling18: 2458–2472KavanaghJNRedmondKMSchettinoGPriseKM2013DNA double strand break repair: a radiation perspective182458247210.1089/ars.2012.5151Search in Google Scholar
Kazama Y, Saito H, Yamamoto YY, Hayashi Y, Ichida H, Ryuto H, Fukunishi N, Abe T (2008) LET-dependent effects of heavy-ion beam irradiation in Arabidopsis thaliana. Plant Biotechnology25: 113–117KazamaYSaitoHYamamotoYYHayashiYIchidaHRyutoHFukunishiNAbeT2008LET-dependent effects of heavy-ion beam irradiation in Arabidopsis thaliana2511311710.5511/plantbiotechnology.25.113Search in Google Scholar
Kennedy AR (2014) Biological effects of space radiation and development of effective countermeasures. Life Science in Space Research1: 10–43KennedyAR2014Biological effects of space radiation and development of effective countermeasures1104310.1016/j.lssr.2014.02.004Search in Google Scholar
Kiffer F, Carr H, Groves T, Anderson JE, Alexander T, Wang J, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR (2017) Effects of 1H + 16O charged particle irradiation on short-term memory and hippocampal physiology in a murine model. Radiation Research189: 53–63KifferFCarrHGrovesTAndersonJEAlexanderTWangJSeawrightJWSridharanVCarterGBoermaMAllenAR2017Effects of 1H + 16O charged particle irradiation on short-term memory and hippocampal physiology in a murine model189536310.1667/RR14843.1Search in Google Scholar
Kim K, Amare Y, Anderson T, Angelaszek D AN, Cheriyan K, Choi GH, Copley M, Coutu S, Derome L, Eraud L, Hagenau L, Han JH, Huh HG, Im S, Jeon JA, Jeong S, Kim MH, Lee HY, Lee J, Lee MH, Liang J, Link JT, Lu L, Lutz L, Mernik T, Mitchell JW, Mognet SI, Morton S, Nester M, Nutter S, Ofoha O, Park IH, Picot-Clémente N, Quinn R, Seo ES, Smith JR, Walpole P, Weinmann RP, Wu J, Yoon YS (2017) Boron And Carbon Cosmic Rays in the Upper Stratosphere (BACCUS). In Proceedings of Science: 35th International Cosmic Ray Conference.KimKAmareYAndersonTAngelaszekD ANCheriyanKChoiGHCopleyMCoutuSDeromeLEraudLHagenauLHanJHHuhHGImSJeonJAJeongSKimMHLeeHYLeeJLeeMHLiangJLinkJTLuLLutzLMernikTMitchellJWMognetSIMortonSNesterMNutterSOfohaOParkIHPicot-ClémenteNQuinnRSeoESSmithJRWalpolePWeinmannRPWuJYoonYS2017InProceedings of Science: 35th International Cosmic Ray Conference10.22323/1.301.0182Search in Google Scholar
Kranz AR (1986) Genetic and physiological damage induced by cosmic radiation on dry plant seeds during space flight. Advances in Space Research6: 135–138KranzAR1986Genetic and physiological damage induced by cosmic radiation on dry plant seeds during space flight613513810.1016/0273-1177(86)90076-1Search in Google Scholar
Krzywinski M, Schein J, Birol I, Connors J, Gascoyne R, Horsman D, Jones SJ, Marra MA (2009) Circos: an information aesthetic for comparative genomics. Genome Research19: 1639–1645KrzywinskiMScheinJBirolIConnorsJGascoyneRHorsmanDJonesSJMarraMA2009Circos: an information aesthetic for comparative genomics191639164510.1101/gr.092759.109275213219541911Search in Google Scholar
Lake JA, Field KJ, Davey MP, Beerling DJ, Lomax BH (2009) Metabolomic and physiological responses reveal multi-phasic acclimation of Arabidopsis thaliana to chronic UV radiation. Plant, Cell and Environment32: 1377–1389LakeJAFieldKJDaveyMPBeerlingDJLomaxBH2009Metabolomic and physiological responses reveal multi-phasic acclimation of Arabidopsis thaliana to chronic UV radiation321377138910.1111/j.1365-3040.2009.02005.x19558413Search in Google Scholar
Lavelle C, Foray N (2014) Chromatin structure and radiation-induced DNA damage: From structural biology to radiobiology. The International Journal of Biochemistry & Cell Biology49: 84–97LavelleCForayN2014Chromatin structure and radiation-induced DNA damage: From structural biology to radiobiology49849710.1016/j.biocel.2014.01.01224486235Search in Google Scholar
LeFrois CE, Zhou M, Amador DM, Sng N, Paul A-L, Ferl RJ (2016) Enabling the spaceflight methylome: DNA isolated from plant tissues preserved in RNAlater™ is suitable for bisulfite PCR assay of genome methylation. Gravitational and Space Research4: 28–37LeFroisCEZhouMAmadorDMSngNPaulA-LFerlRJ2016Enabling the spaceflight methylome: DNA isolated from plant tissues preserved in RNAlater™ is suitable for bisulfite PCR assay of genome methylation4283710.2478/gsr-2016-0010Search in Google Scholar
Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R, Genome Project Data Processing Subgroup (2009) The sequence alignment/map format and SAMtools. Bioinformatics25: 2078–2079LiHHandsakerBWysokerAFennellTRuanJHomerNMarthGAbecasisGDurbinRGenome Project Data Processing Subgroup2009The sequence alignment/map format and SAMtools252078207910.1093/bioinformatics/btp352272300219505943Search in Google Scholar
Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H (2018) DNA N6-adenine methylation in Arabidopsis thaliana. Developmental Cell45: 406–416LiangZShenLCuiXBaoSGengYYuGLiangFXieSLuTGuXYuH2018DNA N6-adenine methylation in Arabidopsis thaliana4540641610.1016/j.mod.2017.04.384Search in Google Scholar
Miller J, Zeitlin C (2016) Twenty years of space radiation physics at the BNL AGS and NASA Space Radiation Laboratory. Life Science in Space Research9: 12–18MillerJZeitlinC2016Twenty years of space radiation physics at the BNL AGS and NASA Space Radiation Laboratory9121810.1016/j.lssr.2016.05.00327345198Search in Google Scholar
Moreno-Villanueva M, Wong M, Lu T, Zhang Y, Wu H (2017) Interplay of space radiation and microgravity in DNA damage and DNA damage response. npj Microgravity3: 14Moreno-VillanuevaMWongMLuTZhangYWuH2017Interplay of space radiation and microgravity in DNA damage and DNA damage response31410.1038/s41526-017-0019-7546023928649636Search in Google Scholar
NASA (2018) Human Research Program Integrated Research Plan. NASA/HRP-47065-RevJ https://humanresearchroadmap.nasa.gov/NASA2018NASA/HRP-47065-RevJ https://humanresearchroadmap.nasa.gov/Search in Google Scholar
NCRP (1995) Radiation Exposure and High Altitude Flight, Commentary #12. Bethesda, MD: US National Council for Radiation Protection and MeasurementsNCRP1995Commentary #12.Bethesda, MDUS National Council for Radiation Protection and MeasurementsSearch in Google Scholar
NOAA (2016) Report and Forecast of Solar and Geophysical Activity, National Oceanic & Atmospheric AdministrationNOAA2016Search in Google Scholar
Robinson JT, Thorvaldsdottir H, Wenger AM, Zehir A, Mesirov JP (2017) Variant review with the integrative genomics viewer. Cancer Research77: e31–e34RobinsonJTThorvaldsdottirHWengerAMZehirAMesirovJP2017Variant review with the integrative genomics viewer77e31e3410.1158/0008-5472.CAN-17-0337567898929092934Search in Google Scholar
Roldán-Arjona T, Ariza RR (2009) Repair and tolerance of oxidative DNA damage in plants. Mutation Research/Reviews in Mutation Research681: 169–179Roldán-ArjonaTArizaRR2009Repair and tolerance of oxidative DNA damage in plants68116917910.1016/j.mrrev.2008.07.00318707020Search in Google Scholar
Sedlazeck FJ, Rescheneder P, Smolka M, Fang H, Nattestad M, von Haeseler A, Schatz MC (2018) Accurate detection of complex structural variations using single-molecule sequencing. Nature Methods15: 461–468SedlazeckFJReschenederPSmolkaMFangHNattestadMvon HaeselerASchatzMC2018Accurate detection of complex structural variations using single-molecule sequencing1546146810.1038/s41592-018-0001-7599044229713083Search in Google Scholar
Smith DJ, Sowa MB (2017) Ballooning for biologists: mission essentials for flying life science experiments to near space on NASA large scientific balloons. Gravitational and Space Research5: 52–73SmithDJSowaMB2017Ballooning for biologists: mission essentials for flying life science experiments to near space on NASA large scientific balloons5527310.2478/gsr-2017-0005Search in Google Scholar
Suman S, Kumar S, Moon B-H, Fornace AJ, Datta K (2017) Low and high dose rate heavy ion radiation-induced intestinal and colonic tumorigenesis in APC1638N/+ mice. Life Sciences in Space Research13: 45–50SumanSKumarSMoonB-HFornaceAJDattaK2017Low and high dose rate heavy ion radiation-induced intestinal and colonic tumorigenesis in APC1638N/+ mice13455010.1016/j.lssr.2017.04.00328554509Search in Google Scholar
Tepfer D, Leach S (2017) Survival and DNA damage in plant seeds exposed for 558 and 682 days outside the International Space Sation. Astrobiology17: 205–215TepferDLeachS2017Survival and DNA damage in plant seeds exposed for 558 and 682 days outside the International Space Sation1720521510.1089/ast.2015.1457536938728263676Search in Google Scholar
Tepfer D, Zalar A, Leach S (2012) Survival of plant seeds, their UV screens, and nptII DNA for 18 months outside the International Space Station. Astrobiology12: 517–528TepferDZalarALeachS2012Survival of plant seeds, their UV screens, and nptII DNA for 18 months outside the International Space Station1251752810.1089/ast.2011.074422680697Search in Google Scholar
Walker KA, Jennings CD, Pulliam J, Ogburn C, Martin GM, Urano M, Turker MS (1997) A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events. Somatic Cell and Molecular Genetics23: 111–121WalkerKAJenningsCDPulliamJOgburnCMartinGMUranoMTurkerMS1997A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events2311112110.1007/BF026799709330639Search in Google Scholar
Wang C, Liu C, Roqueiro D, Grimm D, Schwab R, Becker C, Lanz C, Weigel D (2015) Genome-wide analysis of local chromatin packing in Arabidopsis thaliana. Genome Research25: 246–256WangCLiuCRoqueiroDGrimmDSchwabRBeckerCLanzCWeigelD2015Genome-wide analysis of local chromatin packing in Arabidopsis thaliana2524625610.1101/gr.170332.113431529825367294Search in Google Scholar
Waterworth WM, Bray CM, West CE (2015) The importance of safeguarding genome integrity in germination and seed longevity. Journal of Experimental Botany66: 3549–3558WaterworthWMBrayCMWestCE2015The importance of safeguarding genome integrity in germination and seed longevity663549355810.1093/jxb/erv08025750428Search in Google Scholar
Waterworth WM, Footitt S, Bray CM, Finch-Savage WE, West CE (2016) DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds. Proceedings of the National Academy of Sciences USA113: 9647–9652WaterworthWMFootittSBrayCMFinch-SavageWEWestCE2016DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds1139647965210.1073/pnas.1608829113500324827503884Search in Google Scholar
Zhang Y, Rohde LH, Emami K, Hammond D, Casey R, Mehta SK, Jeevarajan AS, Pierson DL, Wu H (2008) Suppressed expression of non-DSB repair genes inhibits gamma-radiation-induced cytogenetic repair and cell cycle arrest. DNA Repair7: 1835–1845ZhangYRohdeLHEmamiKHammondDCaseyRMehtaSKJeevarajanASPiersonDLWuH2008Suppressed expression of non-DSB repair genes inhibits gamma-radiation-induced cytogenetic repair and cell cycle arrest71835184510.1016/j.dnarep.2008.07.00918703169Search in Google Scholar