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Figure 1

Direct association results between childhood trauma, current depressive symptoms and BMI. All the regression analysis are adjusted for age, sex and smoking (GANI_MED additionally adjusted for cohort).
Direct association results between childhood trauma, current depressive symptoms and BMI. All the regression analysis are adjusted for age, sex and smoking (GANI_MED additionally adjusted for cohort).

Descriptive statistics of all the three study samples: SHIP-2, SHIP-TREND-0 and GANI.MED.

SHIP-2 (N = 1657)SHIP-TREND-0 (N = 3278)GANI_MED (N = 1742)
Sex
females867 (52%)1651 (50%)717 (41%)
Age (mean ± sd)57 ± 13 (range: 31–93)51 ± 15 (range: 20–82)59 ± 48 (range: 19–92)
Smoking status
never639 (39.6%)1221 (37.3%)801 (46%)
ex688 (41.5%)1216 (37.1%)597 (34.3%)
current330 (19.9%)841 (25.7%)344 (19.8%)
BMI (mean ± sd)28.7 ± 4.7 (range: 19.7–49.4)28.4 ± 5.0 (range: 18.5–54.4)29.9 ± 5.2 (range: 18.9–59.1)
Depression score (meanBDI-IIPHQ-9PHQ-9
± sd)6.1 ± 7 (range: 0-58)12.9 ± 3.6 (range: 9–35)15.0 ± 5.6 (range: 9–36)
CTQ sum score (mean ± sd)33.7 ± 9.4 (range: 25–119)33.1 ± 9.5 (range: 25–115)8.0 ± 3.0 (range: 5–25)
Emotional abuse6.2 ± 2.4 (range: 5–25)6.2 ± 2.4 (range: 5–25)1.3 ± 0.9 (range: 1–5)
57.7% no emotional abuse60.7% no emotional abuse83.5% no emotional abuse
Physical abuse5.8 ± 1.9 (range: 5–25)5.7 ± 1.9 (range: 5–25)1.4 ± 0.8 (range: 1–5)
69.8% no physical abuse74.4% no physical abuse79.9% no physical abuse
Sexual abuse5.2 ± 1.3 (range: 5–25)5.2 ± 1.3 (range: 5–25)1.1 ± 0.4 (range: 1–5)
93,4% no sexual abuse94,7% no sexual abuse94,9% no sexual abuse
Emotional neglect9.2 ± 4.4 (range: 5–25)9.0 ± 4.3 (range: 5–25)1.9 ± 1.1 (range: 1–5)
23.1% no emotional neglect25.8% no emotional neglect44.6% no emotional neglect
Physical neglect7.2 ± 2.5 (range: 5–25)7.0 ± 2.5 (range: 5–25)2.3 ± 1.3 (range: 1–5)
37.9% no physical neglect41.1% no physical neglect39.6% no physical neglect
Renal Insufficiency: 113 (6.49%)
Stroke: 254 (14.58%)
Metabolic Syndrome:
- Cardiology: 232 (13.32%)
Clinical cohortsNANA- Psychiatry: 163 (9.36%)
Fatty liver: 126 (7.23%)
Periodontal disease: 404 (23.19%)
Heart failure: 393 (22.56%)
COPD: 57 (3.27%)

Associations between CTQ variables, depression scores (standardized coefficients) and BMI in SHIP-2, SHIP-TREND-0 and GANI. MED.

SHIP-2 (N=1657)SHIP-TREND-0 (N=3278)GANI_MED (N=1742)
Direct effect of CTQ variables on BMI *
CTQ sum scoreβ = 0.16 ± 0.11, p = 0.14β = 0.36 ± 0.1, p < 0.001β = 0.42 ± 0.15, p = 0.005
Emotional abuse scoreβ = 0.09 ± 0.12, p = 0.45β = 0.37 ± 0.11, p < 0.001β = 0.27 ± 0.16, p = 0.087
Physical abuse scoreβ = 0.09 ± 0.12, p = 0.45β = 0.31 ± 0.11, p = 0.003β = 0.43 ± 0.16, p = 0.006
Sexual abuse scoreβ = -0.07 ± 0.12, p = 0.56β = 0.06 ± 0.08, p = 0.45β = 0.30 ± 0.21, p = 0.15
Emotional neglect scoreβ = 0.14 ± 0.11, p = 0.20β = 0.27 ± 0.09, p =0.003β = 0.37 ± 0.13, p = 0.005
Physical neglect scoreβ = 0.26 ± 0.12, p = 0.028β = 0.31 ± 0.09, p = 0.001β = 0.10 ± 0.13, p = 0.42
Direct effect of BDI-II / PHQ-9 on BMI*
BDI-II/PHQ-9β = 0.3 ± 0.14 ,p = 0.027β = 0.56 ± 0.1 , p < 0.001β = 0.34 ± 0.16, p = 0.038
Mediation trough depression score*
Average mediated effect of0.079 (45%)0.137 (38%)0.08 (16.4%)
CTQ sum score by current depression95% CI = (-0.002, 0.162), p ≥ 0.0595% CI = (0.081, 0.199), p < 0.0595% CI = (0.003, 0.16), p < 0.05