<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and microribonucleic acids (miRNAs) organelles and play important roles in intercellular communication and the regulation of tissue regeneration. This transfer of bioactive molecules plays a main role in: tumor invasion and metastasis, immune and inflammation modulation, epithelial-mesenchymal transition and neurobiology. Mesenchymal Stem Cells (MSC) exosomes provide new perspectives for the development of an off-the-shelf and cell-free MSC therapy for the treatment of cartilage injuries and osteoarthritis. This report describes the progress in exosome studies and potential clinical use for osteoarthritis treatment.</p></abstract>

Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and microribonucleic acids (miRNAs) organelles and play important roles in intercellular communication and the regulation of tissue regeneration. This transfer of bioactive molecules plays a main role in: tumor invasion and metastasis, immune and inflammation modulation, epithelial-mesenchymal transition and neurobiology. Mesenchymal Stem Cells (MSC) exosomes provide new perspectives for the development of an off-the-shelf and cell-free MSC therapy for the treatment of cartilage injuries and osteoarthritis. This report describes the progress in exosome studies and potential clinical use for osteoarthritis treatment.

Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment

University of Veterinary Medicine and Pharmacy Komenského

Associated Tissue Bank, Faculty of Medicine of P. J. Šafárik University

Folia Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Role of Mesenchymal Stem Cells\u2014Derived Exosomes in Osteoarthritis Treatment"}

Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can...

Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment

Publicado en línea: 31 dic 2018

Páginas: 19 - 23

Recibido: 17 oct 2018

Aceptado: 12 nov 2018

DOI: https://doi.org/10.2478/fv-2018-0033

Palabras clave
exosomes, osteoarthritis, stem cell, treatment

© 2018 K. Huňáková et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment

Publicado en línea: 31 dic 2018

Páginas: 19 - 23

Recibido: 17 oct 2018

Aceptado: 12 nov 2018

DOI: https://doi.org/10.2478/fv-2018-0033

Palabras claveexosomes, osteoarthritis, stem cell, treatment

© 2018 K. Huňáková et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
exosomes, osteoarthritis, stem cell, treatment